Key research themes
1. How does the DNA damage response coordinate repair and immune signaling to maintain genomic stability and influence cancer therapy?
This research theme explores the crosstalk between the DNA damage response (DDR) pathways and the immune system, emphasizing how DNA lesions activate both repair mechanisms and immune signaling cascades. Understanding this interface is crucial as it reveals how genomic integrity is maintained and how the DDR influences tumor immunogenicity and responsiveness to cancer therapies, including immunotherapy and chemotherapy agents inducing DNA damage.
Key finding: The study discusses how DDR defects in cancer, especially homologous recombination deficiencies (HRD) such as BRCA mutations, create vulnerabilities exploited by PARP inhibitors. It details the interplay between DDR pathways... Read more
Key finding: This paper delineates the intricate balance between genomic instability and DDR in cancer, elaborating on how targeting DNA repair pathways such as BER, NER, MMR, HR, and NHEJ can improve therapeutic outcomes. It underscores... Read more