Papers by Murdani Abdullah
Irritable Bowel Syndrome Diagnosis and Treatment
Colorectal Disease, 2004
Rectal hemangioma
PubMed, Sep 6, 2006
Clinical Endoscopy, Jan 30, 2023
Background/Aims: Endoscopic ultrasound (EUS) has become an essential diagnostic and therapeutic t... more Background/Aims: Endoscopic ultrasound (EUS) has become an essential diagnostic and therapeutic tool. EUS was introduced in 2013 in Indonesia and is considered relatively new. This study aimed to describe the current role of interventional EUS at our hospital as a part of the Indonesian tertiary health center experience. Methods: This retrospective study included all patients who underwent interventional EUS (n=94) at our center between January 2015 and December 2020. Patient characteristics, technical success, clinical success, and adverse events associated with each type of interventional EUS procedure were evaluated. Results: Altogether, 94 interventional EUS procedures were performed at our center between 2015 and 2020 including 75 cases of EUS-guided biliary drainage (EUS-BD), 14 cases of EUS-guided pancreatic fluid drainage, and 5 cases of EUS-guided celiac plexus neurolysis. The technical and clinical success rates of EUS-BD were 98.6% and 52%, respectively. The technical success rate was 100% for both EUS-guided pancreatic fluid drainage and EUS-guided celiac plexus neurolysis. The adverse event rates were 10.6% and 7.1% for EUS-BD and EUS-guided pancreatic fluid drainage, respectively. Conclusions: EUS is an effective and safe tool for the treatment of gastrointestinal and biliary diseases. It has a low rate of adverse events, even in developing countries.
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, Jan 4, 2003
Irritable bowel syndrome (IBS) is the most common functional disorder of the gastrointestinal tra... more Irritable bowel syndrome (IBS) is the most common functional disorder of the gastrointestinal tract. As a result of the lack of specific diagnostic testing and absence of circumscribed biology markers of the disease, its diagnosis is based on a myriad of symptoms. The term irritable bowel syndrome was probably first coined in 1944 by Peters and Bargen. In 1849, Cumming described the clinical manifestations of Irritable Bowel Syndrome. Irritable bowel syndrome is defined on the basis of the recently modified Rome criteria as the presence of at least 12 weeks (not necessarily consecutive) of abdominal discomfort or pain in the preceding 12 months that cannot be explained by structural or biochemical abnormalities, and that has at least two of the following three features: pain relieved with defecation, an onset associated with a change in the frequency of bowel movements (diarrhea or constipation), or an onset associated with a change in form of stool (loose, watery, or pellet-like). The syndrome can be divided into three subcategories according to the Modified Rome criteria II; those with a predominant symptom of diarrhea, constipation, or constipation alternating with diarrhea. There are several criteria for irritable bowel syndrome, one of which is the Manning criteria, applied in many epidemiological and clinical studies to identify irritable bowel syndrome. However, many investigators disagree with this criteria due to a seemingly poor validity in men. In an attempt to bring order to the specialty, consensus-based approach is adopted by a group of international experts, which led to the development of the Rome criteria for irritable bowel syndrome (Table ). Extra-intestinal symptoms, including headache, backache, urinary and gynecologic symptoms, and fatigue, are more common in the constipation-predominant subgroup.
Role of thigh circumference, calf circumference, subjective global assessment, and handgrip strength as diagnostic modalities of sarcopenia in women inflammatory bowel disease patients
JGH open, Jul 28, 2022
Background and AimSarcopenia is a problem affecting inflammatory bowel disease (IBD) outcome and ... more Background and AimSarcopenia is a problem affecting inflammatory bowel disease (IBD) outcome and should be evaluated by measuring muscle mass (using dual‐energy X‐ray absorptiometry [DXA]), muscle strength, and physical performance. DXA has drawbacks as it is expensive, not covered by a national program, and requires a technician. Other inexpensive and simple examinations are needed. The objective is to explore cutoff point and diagnostic accuracy of thigh circumference (TC), calf circumference (CC), subjective global assessment (SGA), and handgrip strength (HGS) to identify sarcopenia in IBD patients.MethodsThe study was conducted in Cipto Mangunkusumo Hospital during November 2020–June 2021. Analysis was performed to discover the cutoff point and diagnostic accuracy of TC, CC, SGA, and HGS to identify sarcopenia.ResultsAs assessed by DXA, 7 of 60 women (11.7%) with IBD had sarcopenia. Using CC cutoff ≤31 cm, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ration (PLR), and negative likelihood ratio (NLR) were 100%, 60.38%, 25%, 100%, 2.52, and 0, respectively. Using TC cutoff ≤50 cm, the sensitivity, specificity, PPV, NPV, PLR, and NLR were 100%, 83.02%, 43.75%, 100%, 5.90, and 0, respectively. SGA has sensitivity, specificity, PPV, NPV, PLR, and NLR of 42.86%, 84.91%, 27.27%, 91.84%, 2.84, and 0.67, respectively. The area under curve of HGS was 33.3%.ConclusionIn this survey of Indonesian women with IBD, the frequency of sarcopenia was 11.7%. When compared with DXA, TC and CC values over 50 cm and 31 cm, respectively, were helpful to exclude the diagnosis of sarcopenia. SGA and HGS were of lesser value for the identification of a decrease in muscle mass.
DOAJ (DOAJ: Directory of Open Access Journals), 2019
Resistensi insulin merupakan gangguan dalam regulasi glukosa yang ditandai dengan peningkatan kad... more Resistensi insulin merupakan gangguan dalam regulasi glukosa yang ditandai dengan peningkatan kadar insulin. Dalam konteks klinik, resistensi insulin dapat bermanifestasi sebagai sindrom metabolik yang memiliki risiko kejadian kardivaskular yang tinggi. Beberapa studi telah melaporkan bahwa resistensi insulin berhubungan langsung terhadap adanya esofagitis erosif pada pasien dengan penyakit refluks gastroesofageal (GERD). Dalam tinjauan pustaka ini, kami akan menelaah pemahaman terbaru yang dapat menjelaskan adanya resistensi insulin pada pasien dengan penyakit refluks gastroesofageal.
Gastroenterology, May 1, 2013
Jurnal Kesehatan Vokasional
Latar Belakang: Prosedur invasif seperti esofagogastroduodenoskopi (EGD) dapat menimbulkan kekhaw... more Latar Belakang: Prosedur invasif seperti esofagogastroduodenoskopi (EGD) dapat menimbulkan kekhawatiran dan kecemasan pada pasien. Diperlukan intervensi tambahan seperti pemberian obat sedasi, intervensi perilaku atau akupunktur untuk membuat pasien tenang dan rileks.Tujuan: Mengetahui efektivitas tindakan press needle di titik akupunktur telinga terhadap kecemasan pasien yang menjalani prosedur EGDMetode: Penelitian randomized controlled trial ini melibatkan 40 pasien yang menjalani EGD tanpa sedasi. Pasien dibagi menjadi dua kelompok, yaitu kelompok perlakuan yang diberikan perangsangan menggunakan press needle di titik akupunktur telinga dan kelompok kontrol yang diberikan jarum placebo. Titik telinga yang dipilih adalah shenmen, relaksasi, dan zero point. Penelitian dilakukan di Pusat Endoskopi Saluran Cerna, RS Dr. Cipto Mangunkusumo, Jakarta. Pasien mengisi kuesioner Spielberger State Anxiety Inventory (SAI) sebelum intervensi dan 10 menit setelah endoskopi selesai melalui ...
F1000Research
Introduction: Coronavirus disease 2019 (COVID-19) cases caused by severe acute respiratory syndro... more Introduction: Coronavirus disease 2019 (COVID-19) cases caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Indonesia remain high. The virus can bind with ACE2 receptor which is not only found in the lungs, but also in the digestive tract. Thus, it allows SARS-CoV-2 infection in the gastrointestinal tract, gastrointestinal manifestations, and detection of viral RNA on anal swab using polymerase chain reaction (PCR). There hasn’t been similar study about the role of anal swab in Indonesia yet. Therefore, this study aims to determine the relationship between SARS-COV-2 anal swab PCR with gastrointestinal clinical manifestations, and the severity of COVID-19 in Indonesia. Methods: This is an analytical study with cross-sectional design. Samples were obtained from hospitalized COVID-19 patients from July 2020 to January 2021. Demographic data, clinical manifestations, severity, and SARS-CoV-2 anal swabs PCR were collected using case report form. Results: A total of...
BMJ Open
ObjectiveTo obtain annual incidence trends, understand clinicopathological characteristics, and f... more ObjectiveTo obtain annual incidence trends, understand clinicopathological characteristics, and forecast the future burden of colorectal cancer (CRC) in Indonesia.Design11-year retrospective cross-sectional study.SettingA national referral hospital in Jakarta, Indonesia.ParticipantsData from 1584 eligible cases were recorded for trends and forecasting analyses; 433 samples were analysed to determine clinicopathological differences between young (<50 years) and old (≥50 years) patients.MethodsTrend analyses were done using Joinpoint software, expressed in annual percentage change (APC), and a regression analysis was executed to generate a forecasting model. Patients’ characteristics were compared using χ2or non-parametric tests.Main outcomesAnalysis of trends, forecasting model, and clinicopathological features between the age groups.ResultsA significant increase in APC was observed among old patients (+2.38%) for CRC cases. Colon cancer increased remarkably (+9.24%) among young p...
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Gastrointestinal tract bleeding is an emergency problem, which is frequently found. The manifesta... more Gastrointestinal tract bleeding is an emergency problem, which is frequently found. The manifestations of gastrointestinal tract bleeding vary, ranging from massive bleeding which is life threatening until occult bleeding that is not sensed by the patient. One of the main objectives in the management of gastrointestinal tract bleeding is stabilizing patient’s hemodynamic, either by using infusion of crystalloid, colloid, or even with the administration of blood transfusion. In massive gastrointestinal tract bleeding, administration of red blood cells transfusion may be life saving. However, in cases where bleeding is not profuse, the safest and most effective blood transfusion strategy is still controversial. Until now, there is no trial that gives information regarding safety and effectiveness of liberal or restrictive transfusion strategy in lower gastrointestinal tract bleeding. However, for most patients with gastrointestinal bleeding, with or without portal hypertension, it is ...
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
Background: Reusing single-use medical devices is a very important and complicated process since ... more Background: Reusing single-use medical devices is a very important and complicated process since theimplementation requires both operational and technical skills, even for professional users. The aim of our studywas to determine the cost effectiveness and efficiency of reusing single-use medical devices. Method: The study was a cross-sectional study conducted between July and December 2013. It compared twogroups of patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) examination at the Digestive Endoscopy Center, Cipto Mangunkusumo Hospital, Jakarta. Patients in the first group received new single-use medical devices; while patients in the other group received the re-used single-use medical devices.Reprocessing for reusing single-used medical devices was conducted according to standard procedures ofdecontamination and sterilization. Results: Reusing medical devices were more commonly found (50.9%) in ERCP procedures than usingnew medical devices (49.1%). Ther...
F1000Research
Background: Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and g... more Background: Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide and genetic mutation plays a vital role in CRC development. A previous study has suggested that genetic alterations among Indonesian patients with CRC might differ from those known in developed countries. This study aimed to describe the genomic profiles of Indonesian patients with CRC. Methods: A total of 13 patients were recruited for this study from May to July 2019. Tissue samples were collected, and genomic DNA was extracted from the samples. AmpliSeq for Illumina Cancer HotSpot Panel v2 Next-generation sequencing was used for DNA sequencing and a genome analysis toolkit was used for local realignment around the discovered variants. Results: A total of 45 genes comprising 391 single nucleotide variants (SNVs) with a depth >10 were observed. The genes with the most variants were STK11, SMAD4, EGFR, and ERBB4 and the genes with the most non-synonymous variants were SMAD4, TP53, FGFR3, C...
Tutor Guidebook Gastrointestinal Module tahun ajaran 2018-2019
Medical Education Unit FKUI, 2019
Student Guide Book Gastrointestinal Module 2018-2019
Tutor Guidebook Gastrointestinal Module TA 2019-2020
Buku Panduan Kerja Mahasiswa (BPKM) Modul Gastrointestinal
Medical Education Unit Fakultas Kedokteran Universitas Indonesia, 2019
Digestion, 2021
Introduction: The COVID-19 outbreak abruptly restricted gastrointestinal (GI) endoscopy services ... more Introduction: The COVID-19 outbreak abruptly restricted gastrointestinal (GI) endoscopy services during the first wave of the pandemic. We aimed to assess the impact of COVID-19 on the practice of GI endoscopy in Asian countries. Methods: This was an International Questionnaire-based Internet Survey conducted at multiple facilities by the International Gastrointestinal Consensus Symposium. A total of 166 respondents in Japan, China, Hong Kong, South Korea, Philippines, Thailand, Indonesia, and Singapore participated in this study. Results: The volume of endoscopic screening or follow-up endoscopies and therapeutic endoscopies were markedly reduced during the first wave of the pandemic, which was mainly attributed to the decreased number of outpatients, cancellations by patients, and adherence to the guidelines of academic societies. The most common indications for GI endoscopy during the first wave were GI bleeding, cholangitis or obstructive jaundice, and a highly suspicious case o...
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2014
Background: Hepatocellular carcinoma (HCC) remains a major problem throughout the world, especial... more Background: Hepatocellular carcinoma (HCC) remains a major problem throughout the world, especially in diagnostic and therapeutic management. Previous studies stated that alpha-1 acid glycoprotein (AAG) was a potensial biomarker in diagnostic of HCC. This study assessed the best cut-off value of AAG as a diagnostic biomarker of HCC with liver cirrhosis. Method: This was a cross-sectional, diagnostic study, conducted from January to October 2013 in Cipto Mangunkusumo Hospital. The subjects were HCC with liver cirrhosis patients and as control were liver cirrhosis patients. Abdominal ultrasonography (USG), abdominal 3 phase contrast computerized tomography (CT) scan, and liver biopsy, if necessary, were done. All patients were having AAG examination, then the result was analyzed using receiver operating characteristic (ROC) curve and assessment of some cut-off values was done. Results: There were 25 HCC with liver cirrhosis patients and 37 liver cirrhosis patients as control included ...
BMJ Open Gastroenterology, 2021
ObjectiveThis study will test the performance of the anal swab PCR test when compared with the na... more ObjectiveThis study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19.DesignAn observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia. Epidemiological, clinical, laboratory and radiology data were obtained. Nasopharyngeal and anal swabs specimens were collected for SARS-CoV-2 RNA detection.ResultsWe analysed 136 subjects as part of this study. The clinical spectrum of COVID-19 manifesation in this study was typical of hospitalised patients, with 25% classified as mild cases, 14.7% in severe condition and 12.5% of subjects classified as having acute respiratory distress syndrome. When compared with nasopharyngeal swab as the standard specimen for reverse transcription polymeras...
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Papers by Murdani Abdullah