Papers by Daniela Montesarchio
Inter/Azioni tra saperi: una visione in 3D. Diritto allo Studio, Democrazia dei Saperi, Donne nella Scienza
Scientific Reports, 2021
In several biomedical applications, the detection of biomarkers demands high sensitivity, selecti... more In several biomedical applications, the detection of biomarkers demands high sensitivity, selectivity and easy-to-use devices. Organic electrochemical transistors (OECTs) represent a promising class of devices combining a minimal invasiveness and good signal transduction. However, OECTs lack of intrinsic selectivity that should be implemented by specific approaches to make them well suitable for biomedical applications. Here, we report on a biosensor in which selectivity and a high sensitivity are achieved by interfacing, in an OECT architecture, a novel gate electrode based on aptamers, Au nanoparticles and graphene hierarchically organized to optimize the final response. The fabricated biosensor performs state of the art limit of detection monitoring biomolecules, such as thrombin-with a limit of detection in the picomolar range (≤ 5 pM) and a very good selectivity even in presence of supraphysiological concentrations of Bovine Serum Albumin (BSA-1mM). These accomplishments are th...
Bioorganic Chemistry, 2019
Dalton Transactions, 2016
The reactivity ofcis-PtI2(NH3)2with selected DNA model systems, in single, double strand or G-qua... more The reactivity ofcis-PtI2(NH3)2with selected DNA model systems, in single, double strand or G-quadruplex form, has been studied by circular dichroism, UV-visible spectroscopy and electrospray mass spectrometry using cisplatin as a control.
Proceedings of 7th International Electronic Conference on Medicinal Chemistry, Nov 5, 2021
Developing functionalized Fe<sub>3</sub>O<sub>4</sub>–Au nanoparticles: a physico-chemical insight
Physical Chemistry Chemical Physics, 2015
Pharmacology & Therapeutics, 2021
Materials research proceedings, Mar 20, 2020
A New Class of Potential Antineoplastic Agents Based on Ruthenium Amphiphilic Nanostructures
Synthesis and conformational analysis of a novel carbohydrate-fused bis-crown ether: crown-CyPLOS
Tetrahedron, Nov 1, 2009
ABSTRACT A novel sugar-based macrocycle consisting of a phosphate-linked 12-membered disaccharide... more ABSTRACT A novel sugar-based macrocycle consisting of a phosphate-linked 12-membered disaccharide ring (cyclic phosphate-linked oligosaccharide, CyPLOS), fused to two 18-crown-6 ether residues, is here described. The synthesis of the target compound has been accomplished in 23% overall yield for 11 reaction steps, exploiting phosphoramidite chemistry for the dimerization and a classical phosphotriester methodology for the cyclization reaction. NMR-based conformational analysis studies have been carried out on the fully deprotected macrocycle, showing a characteristic arched-structure with C2-symmetry.Graphical abstract
A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers
Molecular therapy. Nucleic acids, Dec 1, 2022
Chemical & Pharmaceutical Bulletin, 2003
8-CF3-2’-deoxyguanosine as a useful nucleoside analog for 19F NMR-based structural studies of G-quadruplex structures
Affinity Chromatography‐Based Assays for the Screening of Potential Ligands Selective for G‐Quadruplex Structures
ChemistryOpen
International Journal of Molecular Sciences, 2021
In the search for optimized thrombin binding aptamers (TBAs), we herein describe the synthesis of... more In the search for optimized thrombin binding aptamers (TBAs), we herein describe the synthesis of a library of TBA analogues obtained by end-functionalization with the electron-rich 1,5-dialkoxy naphthalene (DAN) and the electron-deficient 1,8,4,5-naphthalenetetra-carboxylic diimide (NDI) moieties. Indeed, when these G-rich oligonucleotides were folded into the peculiar TBA G-quadruplex (G4) structure, effective donor–acceptor charge transfer interactions between the DAN and NDI residues attached to the extremities of the sequence were induced, providing pseudo-cyclic structures. Alternatively, insertion of NDI groups at both extremities produced TBA analogues stabilized by π–π stacking interactions. All the doubly-modified TBAs were characterized by different biophysical techniques and compared with the analogues carrying only the DAN or NDI residue and unmodified TBA. These modified TBAs exhibited higher nuclease resistance, and their G4 structures were markedly stabilized, as evi...
International Journal of Biological Macromolecules, 2019
Journal of Inorganic Biochemistry, 2019
Journal of Nucleic Acids, 2010
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Papers by Daniela Montesarchio