Neha Grewal

The central role of chemistry in ‘quality by design’ approaches to drug development

Future Medicinal Chemistry, Sep 1, 2012

The quality of medicines reaching the consumer is strictly controlled and maintained by the regul... more The quality of medicines reaching the consumer is strictly controlled and maintained by the regulatory agencies of the world. Pharmaceutical companies have to meet and maintain these regulatory quality standards. For this purpose, an increasing number of processes are incorporating quality by design (QbD) principles. Implementation of QbD involves chemistry in several ways, such as in the development of new synthetic and analytical methods, avoiding formation of genotoxic impurities and designing drug-like compounds to improve the quality of biological profile of medicines. A combined effort from regulatory authorities, pharmaceutical industries and academic research groups could also facilitate QbD implementation.

Mechanistic Studies and Optimization of Microwave-Assisted Palladium-Catalyzed Carbon-Carbon Bond Forming Reactions and an Academic Prospective on “Quality by Design”

This compilation of work includes four aspects: (1) an academic review on the significance and im... more This compilation of work includes four aspects: (1) an academic review on the significance and implementation of Quality by Design (QbD), ( ) mechanistic studies on the palladium-catalyzed synthesis of diarylmethanes, (3) the optimization of microwave-assisted click reactions and Suzuki couplings for use in an undergraduate organic chemistry laboratory manual, and (4) monitoring the progress of organic transformations using Raman spectroscopy.

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Mechanistic Studies and Optimization of Microwave-Assisted Palladium-Catalyzed Carbon-Carbon Bond Forming Reactions and an Academic Prospective on “Quality by Design”

This compilation of work includes four aspects: (1) an academic review on the significance and im... more This compilation of work includes four aspects: (1) an academic review on the significance and implementation of Quality by Design (QbD), ( ) mechanistic studies on the palladium-catalyzed synthesis of diarylmethanes, (3) the optimization of microwave-assisted click reactions and Suzuki couplings for use in an undergraduate organic chemistry laboratory manual, and (4) monitoring the progress of organic transformations using Raman spectroscopy.

Download

The central role of chemistry in 'quality by design' approaches to drug development

Future medicinal chemistry, 2012

The quality of medicines reaching the consumer is strictly controlled and maintained by the regul... more The quality of medicines reaching the consumer is strictly controlled and maintained by the regulatory agencies of the world. Pharmaceutical companies have to meet and maintain these regulatory quality standards. For this purpose, an increasing number of processes are incorporating quality by design (QbD) principles. Implementation of QbD involves chemistry in several ways, such as in the development of new synthetic and analytical methods, avoiding formation of genotoxic impurities and designing drug-like compounds to improve the quality of biological profile of medicines. A combined effort from regulatory authorities, pharmaceutical industries and academic research groups could also facilitate QbD implementation.

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