Sara ibrahim

Followers

Following

Public Views

Uploads

Papers by Sara ibrahim

Predictive Factors of Rapid Linear Renal Progression and Mortality in Patients with Chronic Kidney Disease

Background: Risk factors predictive of rapid linear chronic kidney disease (CKD) progression and ... more Background: Risk factors predictive of rapid linear chronic kidney disease (CKD) progression and its associations with end-stage renal disease (ESRD) and mortality requires further exploration, particularly as patients with linear estimated glomerular filtration rate (eGFR) trajectory represent a clear paradigm for understanding true CKD progression. Methods: A linear regression slope was applied to all outpatient eGFR values for patients in the Salford Kidney Study who had ≥2 years follow-up, ≥4 eGFR values and baseline CKD stages 3a-4. An eGFR slope (ΔeGFR) of ≤ -4 ml/min/1.73m 2 /yr defined rapid progressors, whereas -0.5 to + 0.5 ml/min/1.73m 2 /yr defined stable patients. Binary logistic regression was utilised to explore variables associated with rapid progression and Cox proportional hazards model to determine predictors for mortality prior to ESRD. Results: There were 157 rapid progressors (median ΔeGFR -5.93 ml/min/1.73m 2 /yr) and 179 stable patients (median ΔeGFR -0.03 ml/min/1.73m 2 /yr). Over 5 years, rapid progressors had an annual rate of mortality or ESRD of 47 per 100 patients compared with 6 per 100 stable patients. Factors associated with rapid progression included younger age, female gender, higher diastolic pressure, higher total cholesterol:high density lipoprotein ratio, lower albumin, lower haemoglobin and a urine protein:creatinine ratio of > 50 g/mol. The latter three factors were also predictive of mortality prior to ESRD, along with older age, smoking, peripheral vascular disease and heart failure. Conclusions: There is a heterogenous interplay of risk factors associated with rapid linear CKD progression and mortality in patients with CKD. Furthermore, rapid progressors have high rates of adverse outcomes and require close specialist monitoring.

Download

Effect of Cesarean Section on Demand on the phenomena of Increasing Cesarean Section Rate at Women's Health Hospital

Assiut Scientific Nursing Journal (Print), Dec 1, 2018

Aims of the study were to determine the hospital based rate of C.S at Assiut Women's Health Hospi... more Aims of the study were to determine the hospital based rate of C.S at Assiut Women's Health Hospital and assess the effect of C.S on demand on increasing C.S rate. Setting: This study was conducted at Assiut Women's Health Hospital, postpartum unit .Sample: A convenience sample (1500) of all postpartum women who had C.S during a three months period. Design: A cross -sectional descriptive study design was used in this study. Results: Cesarean section rate in hospital was 47.3% at 2016 and cesarean section on demand accounts for about 5.5% of the rate of C.S and in the present study findings. Conclusion: C.S which was done on maternal demand was accounted for 5.5%, as it might increase the rate of hospital based rate of C.S. Recommendations: Implementation of counseling sessions for pregnant women to improve awareness of vaginal delivery benefits, indications for C.S and the consequences of performing an elective or an unnecessary C.S.

Download

Hepatitis C virus and neurological damage

World Journal of Hepatology, Apr 28, 2016

Core tip: There is high prevalence rate of neuropsychiatric ailments with respect to patients inf... more Core tip: There is high prevalence rate of neuropsychiatric ailments with respect to patients infected with chronic hepatitis C virus (HCV). Brain inflammatory disorders, cerebrovascular disease peripheral neuropathy, psychiatric disturbs and cognitive symptoms are the complex clinical signs which occurs when infected by chronic HCV infection. HCV prompts psychiatric and neurological symptoms through numerous pathways with imprecise mechanisms, which includes neurotransmitter and metabolic pathway imbalance, immune-mediated responses and direct brain neurotoxicity inflammation. Awareness of HCV-associated neuropsychiatric disorders and its pathogenic mechanisms is vital to understand the clinical manifestations and to introduce an applicable treatment.

Download

The impact of continuous retrograde cardioplegia compared with intermittent antegrade cardioplegia on left and right ventricular functions during coronary artery grafting in patients with left ventricular dysfunction ( transesophageal echocardiography examination and electron microscopic evaluation)

Background During coronary artery bypass grafting (CABG), both the quality of myocardial protecti... more Background During coronary artery bypass grafting (CABG), both the quality of myocardial protection and the preoperative myocardial status directly influence the postoperative cardiac outcome, recovery, and complications. The aim of this study was to compare the protective effects of continuous retrograde cold blood cardioplegia with intermittent antegrade cold blood cardioplegia at systemic normothermia on left ventricular (LV) and right ventricular (RV) systolic and diastolic functions in patients with poor myocardial contractility, who underwent CABG surgery, in terms of the intraoperative course and the postoperative clinical outcome. Patients and methods Patients were randomly divided into two equal groups (20 patients each) according to the myocardial protection technique: antegrade group: intermittent antegrade cold blood cardioplegia and retrograde group: continuous retrograde cold blood cardioplegia. In the antegrade group, warm cardioplegia was administered through an aort...

Serum vitamin D levels in patients with atopic asthma

Egyptian Journal of Chest Diseases and Tuberculosis, 2015

Background It must be obvious that no one factor should be held accountable for the etiology of a... more Background It must be obvious that no one factor should be held accountable for the etiology of allergic diseases, asthma or acute asthma exacerbations. Operating on a genetic basis many factors must play a role. It has been postulated that vitamin D deficiency, as a result of industrialization and Westernized lifestyles that have led to sun-avoidance behaviors and more time indoors, has a role in the development of asthma and allergies (Green, 2010) [1]. Objective To assess the relationship between serum vitamin D levels and severity of asthma in patients with atopic asthma. Patients and methods The study was carried out on 30 patients with atopic asthma, divided into three groups according to severity of airway obstruction, and ten healthy control subjects. Serum 25-hydroxyvitamin D 3 [25(OH) D], a vitamin D metabolite, was measured using an immunodiagnostic ELISA technique. Results 86% of all asthmatic patients were vitamin D insufficient, as defined by a level ⩽30 ng/ml 25(OH) V...

Download

Mosquito repellents: Killing mosquitoes or yourselves

Introduction: Mosquito repellents are most commonly used in Pakistan. Now a day it’s used has inc... more Introduction: Mosquito repellents are most commonly used in Pakistan. Now a day it’s used has increased because of dengue, malaria and yellow fever. There are many types of mosquito repellents including sprays, lotions creams and coils etc. The main constituent of mosquito repellent is DEET which is hazardous to human health. Many people are allergic to these repellents. The aim of current study is to determine the risk and hazards due to the use of mosquito repellents. Methodology: The survey was conducted at different clinics, hospitals, colleges and other different public places with and without complains of reactions on prolong use or even having information regarding toxicity. People presenting with primary complain of skin reactions were significantly due to illiteracy, using cheap and low standard products and excessive use of repellents. Result: Most of the people used mosquito repellents as a precaution to dengue and malaria. Illiterate people preferred coils due to their l...

Download

The liver regeneration associated factor ALR attenuates IL-6 induced acute-phase reactants during hepatic inflammation

Zeitschrift Fur Gastroenterologie, 2016

Diverse reactions of PhI(OTf)2 with common 2-electron ligands: complex formation, oxidation, and oxidative coupling

Inorganic chemistry, 2012

The crystal structures of bis-pyridine stabilized iodine dications [PhI(pyr)(2)](2+) are reported... more The crystal structures of bis-pyridine stabilized iodine dications [PhI(pyr)(2)](2+) are reported as triflate salts, representing the first ligand supported iodine dications to be structurally characterized. The pyridine complexes are susceptible to ligand exchange in reaction with stronger N-based donors such as 4-dimethylaminopyridine. Attempts to extend this reactivity to N-heterocyclic carbene and phosphine ligands, as has been accomplished in the earlier p-block groups, resulted in redox chemistry, with oxidation of the ligands rather than coordination.

What to use for bronchial asthma; nebulized or intravenous magnesium sulfate?

Egyptian Journal of Chest Diseases and Tuberculosis, 2017

Background Asthma is characterized by airways narrowing and airflow limitation. The conventional ... more Background Asthma is characterized by airways narrowing and airflow limitation. The conventional therapy for asthma exacerbation is usually efficient but sometimes patients not respond to it, consequently; other additive drugs may be used as magnesium sulfate(MgSO 4 ) either intravenously or by nebulization. Objective To compare the bronchodilator effect of MgSO 4 via intravenous injection and nebulization in controlling asthma exacerbation. Methods 40 patients with asthma exacerbation were equally and randomly enrolled in two groups. One group received nebulized MgSO 4 (A), and the other group received intravenous MgSO 4 (B). Results Improvement was higher in group B than in group A but without significant change in PEFR also there was no high significant difference in the two group parameters after MgSO 4 treatment. Complications were few and manageable in both groups. Conclusion Intravenous MgSO 4 is effective affordable and cheap drug for asthma exacerbation management with good...

Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats

Biomedicines, 2018

Innovative drug-delivery systems offer a unique approach to effectively provide therapeutic drug ... more Innovative drug-delivery systems offer a unique approach to effectively provide therapeutic drug dose over the needed time to achieve better tissue protection and enhanced recovery. The hypothesis of the current study was to test the antioxidant and anti-inflammatory effects of genistein and nanofibers on the spinal cord tissue following experimental spinal cord injury (SCI). Rats were treated post SCI with genistein that is loaded on chitosan/polyvinyl alcohol (CS/PVA) nanofibers as an implantable drug-delivery system. SCI caused marked oxidative damage and inflammation, as is evident by the reduction in the super oxide dismutase (SOD) activity and the level of interleukin-10 (IL-10) in injured spinal cord tissue, as well as the significant increase in the levels of nitric oxide (NO), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-α). Treatment of rats post SCI with genistein and CS/PVA nanofibers improved most of the above-mentioned biochemical parameters and shifted ...

Download

The prognostic utility of plasma osteopontin in CAP patients

Egyptian Journal of Chest Diseases and Tuberculosis, 2017

Background: Osteopontin (OPN) is a soluble cytokine glycoprotein widely expressed in many benign ... more Background: Osteopontin (OPN) is a soluble cytokine glycoprotein widely expressed in many benign and malignant conditions. Purpose of study: was to investigate role of plasma OPN as new biomarker affects prognosis in CAP. Methodology: study was done on 50 subjects divided into 2 groups each 25, CAP (group I), healthy controls (group II). Plasma OPN levels were measured on initial hospitalization and after 3 days of treatment and correlated to severity of CAP by CRP and CURB-65. We concluded that: plasma levels of OPN is increased in pneumonia patients than in healthy controls also before than after 3 days of treatment of CAP. OPN levels significantly correlated with CURB-65 scores but not with CRP levels. Thus, OPN can be used as a novel additional marker, reflecting severity and response to treatment in CAP.

Over the decades, the medical industry has been challenged with the issue of producing drugs that... more Over the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions). Many researches have shown that complex diseases, such as various cancers, make the “one disease one target one drug” strategy unsuccessful due to the intrinsic complexity of gene-gene interactions and gene-environment interactions. In order to discover efficient treatments for these diseases, we assume that optimal drugs should be capable of down-regulating the effects of overexpressed genes while activating the under-expressed genes, when necessary, to restore the patient’s status to a healthy one. In this MURI project, we constructed drug-drug similarity network models, as two drugs having similar side effects, targets or chemical structures may have compatible therapeutic effects on the diseases. First, we retrieved a list of top-ranking drugs for specific diseas...

Download

1164-P: A Zebrafish Nonalcoholic Fatty Liver Disease Model Links Liver Inflammation with Pancreatic Inflammation and Hyperglycemia

Diabetes, 2021

The spectrum of nonalcoholic liver disease (NAFLD) ranges from simple steatosis to steatohepatiti... more The spectrum of nonalcoholic liver disease (NAFLD) ranges from simple steatosis to steatohepatitis with the latter having the potential to irreversibly progress to cirrhosis. Compared with the general population, NAFLD is more frequently seen in patients with type 2 diabetes (T2D), and conversely, NAFLD is associated with increased incidence of T2D. Existing rodent models of NAFLD focus narrowly on certain stages of liver damage and insufficiently encompass all metabolic changes, limiting their utility. The aims of this study were to develop a new model of NAFLD in young zebrafish and use it to probe the associations between liver inflammation and pancreatic islet function. We examined hepatopancreatic inflammation under three conditions: (1) in a zebrafish line (fabp10-CETI-PIC3) in which liver-specific expression of pro-inflammatory cytokines IL-1β, TNFα, and IFN-γ was induced by doxycycline treatment (M1); (2) in wild-type zebrafish fed a high-fat diet (M2); and (3) in a combinat...

Attenuated lipotoxicity and apoptosis is linked to exogenous and endogenous augmenter of liver regeneration by different pathways

PLoS ONE, 2017

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum from simple steatosis to nonalcoholic ... more Nonalcoholic fatty liver disease (NAFLD) covers a spectrum from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Free fatty acids (FFA) induce steatosis and lipo-toxicity and correlate with severity of NAFLD. In this study we aimed to investigate the role of exogenous and endogenous ALR (augmenter of liver regeneration) for FFA induced ER (endoplasmatic reticulum) -stress and lipoapoptosis. Primary human hepatocytes or hepatoma cells either treated with recombinant human ALR (rhALR, 15kDa) or expressing short form ALR (sfALR, 15kDa) were incubated with palmitic acid (PA) and analyzed for lipo-toxicity, -apoptosis, activation of ER-stress response pathways, triacylglycerides (TAG), mRNA and protein expression of lipid metabolizing genes. Both, exogenous rhALR and cytosolic sfALR reduced PA induced caspase 3 activity and Bax protein expression and therefore lipotoxicity. Endogenous sfALR but not rhALR treatment lowered TAG levels, diminished activation of ER-stre...

Download

Significance of Moraxella catarrhalis as a causative organism of lower respiratory tract infections

Egyptian Journal of Chest Diseases and Tuberculosis, 2017

Background Moraxella catarrhalis is an exclusively human pathogen that may be overlooked in cultu... more Background Moraxella catarrhalis is an exclusively human pathogen that may be overlooked in culture because of its phenotypic similarity to commensal Neisseria. Indeed, beta lactamase producing isolates of M. catarrhalis appear to be wide spread, and this may play an important role in the therapy of infections, particularly in the treatment of mixed infections Objective The purpose of this study was to evaluate the significance of M. catarrhalis as a pathogen in causing lower respiratory tract infection. Methods This study was carried out on 200 patients who were diagnosed as having lower respiratory tract infection and admitted during the period of the research to chest unit of Tanta University hospitals, another 50 adult volunteer were considered as control group during the period from January 2014 to August 2014. All patients were subjected to the following assessment, full clinical history; their records were reviewed for name, age, sex, and special habits. Patients suspected to...

Download

Osteopontin role in community-Acquired Pneumonia (CAP)

European Respiratory Journal, 2017

Background: Osteopontin (OPN) is a phosphorylated acidic glycoprotein firstly was related to cell... more Background: Osteopontin (OPN) is a phosphorylated acidic glycoprotein firstly was related to cell growth, differentiation in malignancy process. Now it seems that OPN paly major role in cell recruitment and regulation of inflammation. Also found to be associated with elevated mediators, cellularity and Th1cytokines expression at inflammation sites. Purpose of study: to compare OPN plasma level between community acquired pneumonia (CAP) and control healthy subjects. Also to correlate between OPN and disease severity. Methods: Study was conducted on 2groups, Group I: included 25 CAP patients. Group II: included 15 age-matched healthy control subjects admitted in Chest Department, Tanta University Hospitals. OPN levels were measured in serum by (ELISA). CURB-65 score, hospitalization length and CRP were used to detect severity in CAP patients on hospitalization. Results: Mean value of serum OPN in group I was (78.42 ± 8.7) ng/ml while in group II was (19.43 ± 8.3) ng/ml. OPN was signif...

The level of bronchoalveolar lavage fluid prostaglandine E2; Is it diagnostic of bronchogenic carcinoma?

Egyptian Journal of Chest Diseases and Tuberculosis, 2012

Lung cancer is the most common cause of cancer mortality. It constitutes 12.8% of cancer cases an... more Lung cancer is the most common cause of cancer mortality. It constitutes 12.8% of cancer cases and causes 17.8 % of cancer death,global incidence of lung cancer is increasing 0.5% per a year. Prostaglandins are found in most tissues and organs and produced by nucleated cells. Prostaglandins are autocrine or paracrine horomoeswhich are locally acting messenger molecules.They differ from hormones in that they are not produced at a discrete site but in many places throughout the human body. Prostaglandins are potent,have a short half-life before being inactivated and excreted. Increased amounts of PGE2 are produced in several pathologic conditions, including inflammation, arthritis, tissue injury and wide variety of cancers.Subjects and methods:The study was conducted on forty subjects; including 20 patients with bronchogenic carcinoma (Group 3),10 patients with non-malignant lesions (Group 2),and 10 healthy control subjects (Group 1).All subjects were submitted to fiberoptic bronchosc...

Download

What is your diagnosis? Clinicopathological correlation

Journal of the Egyptian Womenʼs Dermatologic Society, 2015

Histopathological examination of both cases revealed a dome-shaped nodular skin lesion composed o... more Histopathological examination of both cases revealed a dome-shaped nodular skin lesion composed of multiple dilated infundibulocystic structures filled with keratin with only focal epidermal communications. Numerous sebaceous lobules were attached to the infundibular structures. The follicular structures were surrounded with fibrous sheaths and were separated from the adjacent stroma by cleft-like spaces (Fig. 2). The stroma appeared densely collagenous (black arrow, Fig. 2a) with spindle cells (dashed arrow, Fig. 2a), foci of adipocytes (diamond headed and black arrows, Fig 2a and b, respectively), and vascular spaces. What is your diagnosis? Diagnosis The histopathological findings are diagnostic of folliculosebaceous cystic hamartoma (FSCH).

Leukotriene B4 as an early predictor of carotid atherosclerosis in patients with obstructive sleep apnea

European Respiratory Journal, 2014

There is an increased risk of cardiovascular and cerebrovascular events in patients with obstruct... more There is an increased risk of cardiovascular and cerebrovascular events in patients with obstructive sleep apnea (OSA). An increased intima-media thickness (IMT)in the carotid arteries is a marker of atherosclerosis, associated with a high risk of stroke. Leukotriene B4 (LTB4) is a powerful pro-inflammatory mediator in several inflammatory diseases,including atherosclerosis. The aim was to elucidate the relationship between LTB4 and carotid atherosclerosis in OSA patients without known cardiovascular,cerebrovascular disease.methods:10 healthy volunteer as a control group (groupI) and 40 patients known to have obstructive sleep apnea (groupII). Doppler ultrasonography used to measure carotid IMT. leukotriene B4 levels were measured.Obstructive sleep apnea was diagnosed by polysomnography.serum leukotriene B4 levels were significantly higher in the OSA group. This high level was positively correlated with desaturation index, AHI and with the IMT. Conclusion:patients with OSA have elev...

Utility of bone marrow mononuclear cells as a novel therapy in chronic obstructive pulmonary diseases

The Egyptian Journal of Chest Diseases and Tuberculosis, 2018

Background Stem cells have undifferentiated cells that have can proliferate to one or more cells.... more Background Stem cells have undifferentiated cells that have can proliferate to one or more cells. Exogenous stem cells derived from embryonic and adult tissues could be used in the regeneration of diseased organs, including lung and tissue. Chronic obstructive pulmonary disease (COPD) pathogenesis plays a major role in the upregulation of inflammation, making irreversible procedure, like apoptosis of cells, lysis of the components of extracellular matrix in lung. All treatments of COPD to date have involved pharmacological therapy and mainly target the symptoms; hence, there is an urgent need for novel and more effective therapeutic strategies. Mesenchymal stem cells are considered a therapy in COPD more for their immune modulatory effects. Aim This study aimed to evaluate the effect of stem cell therapy on mild-to-moderate COPD patients, either by infusion or by inhalation, on the basis of pulmonary function tests and quality of life. Patients and methods This study was carried out...

Sara ibrahim

Uploads

Papers by Sara ibrahim

Log In