The use of a Domain Ontology for the Management of Essential Hypertension (Preprint)
BACKGROUND : Currently, hypertension is one of the diseases with greater risk of mortality in the... more BACKGROUND : Currently, hypertension is one of the diseases with greater risk of mortality in the world. Particularly in Chile, 90% of the population with this disease has idiopathic or essential hypertension. Essential hypertension is characterized by high blood pressure rates and it´s cause is unknown, which means that every patient might requires a different treatment, depending on their history and symptoms. Different data, such as history, symptoms, exams, etc., are generated for each patient suffering from the disease. This data is presented in the patient’s medical record, in no order, making it difficult to search for relevant information. Therefore, there is a need for a common, unified vocabulary of the terms that adequately represent the diseased, making searching within the domain more effective. OBJECTIVE The objective of this study is to develop a domain ontology for essential hypertension , therefore arranging the more significant data within the domain as tool for me...
Description Systemic lupus erythematosus (SLE) is an autoimmune disease affecting all age groups ... more Description Systemic lupus erythematosus (SLE) is an autoimmune disease affecting all age groups and can manifest in various forms, often making the initial or successive presentations difficult to diagnose. Peritonitis secondary to lupus is a rare manifestation of this disease and the prevalence is said to be much lower in children. We present a case report of an adolescent male with a known history of lupus who presented to the emergency department with a clinical picture consistent with an acute surgical abdomen and underwent an appendectomy. Subsequent workup identified the culprit as a lupus-related peritonitis requiring corticosteroids for resolution.
Get up, stand up, stand up for your health! Faculty and student perspectives on addressing prolonged sitting in university settings
Journal of American College Health
Parental Knowledge of Appropriate Placement of Child Restraint Systems Before and After Educational Intervention in a Pediatric Emergency Department
Pediatric Emergency Care
Interaction Of Platelets With Red Cell-Derived Microparticles (RMP): RMP Increase Platelet Aggregate Size In a Shear-Dependent Manner
Blood
Background Red cell microparticles (RMP) have come to recent attention as putative mediators of h... more Background Red cell microparticles (RMP) have come to recent attention as putative mediators of hemostasis. We reported that RMP improve hemostatic defect of blood samples of thrombocytopenia and thrombocytopathy and augment platelet function. To investigate possible mechanisms of this activity, we measured the effect of RMP on shear-dependent platelet adhesion and aggregation in whole blood. Methods RMP were produced by high-pressure extrusion of washed, packed RBC. The RMP produced in this way are similar to natural circulating RMP in phenotype and most functional assays. Blood was collected in citrate Vacutainers from normal healthy staff volunteers, and first 3 mL discarded to minimize artifact of platelet activation due to tissue factor. It was tested within 2 hours of drawing. Variable shearing rates were applied by a cone-and-plate device, the DiaMed Impact-R, which yields photomicrographs of objects adhering to the plate, and data including percent surface coverage (SC), num...
Fluency Strategies of Spanish–English Bilinguals Who Stutter: A Thematic Analysis
Perspectives of the ASHA Special Interest Groups
Purpose Stuttering is multifaceted in that the frequency and types of behaviors vary across speak... more Purpose Stuttering is multifaceted in that the frequency and types of behaviors vary across speakers, contexts, and languages. Similarly, bilingualism varies in language history, levels of proficiency, and languages spoken. The variations in bilingualism make it difficult to investigate and result in knowledge gaps about the bilingual stuttering experience. The purpose of this exploratory, qualitative study is to identify and examine fluency-inducing strategies used by Spanish–English bilingual adults who stutter. Method Twenty Spanish–English bilingual adults who stutter, ages 18–61 years, answered open-ended questions about their stuttering and language history via an online survey. Thematic analysis procedures were used to explore participants' narrative responses to 2 survey items regarding fluency-inducing strategies. Result Three major themes emerged from participants' responses regarding self-reported strategies: (a) clinical techniques, (b) focused breathing, and (c)...
The importance of drug safety and tolerability in the development of new immunosuppressive therapy for transplant recipients: The Transplant Therapeutics Consortium's position statement
Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are glomerular... more Minimal change disease (MCD) and primary focal segmental glomerulosclerosis (FSGS) are glomerular diseases characterized by nephrotic syndrome. Their diagnosis requires a renal biopsy, but it is an invasive procedure with potential complications. In a small biopsy sample, where only normal glomeruli are observed, FSGS cannot be differentiated from MCD. The correct diagnosis is crucial to an effective treatment, as MCD is normally responsive to steroid therapy, whereas FSGS is usually resistant. The purpose of our study was to discover and validate novel early urinary biomarkers capable to differentiate between MCD and FSGS. Forty-nine patients biopsy-diagnosed of MCD and primary FSGS were randomly subdivided into a training set (10 MCD, 11 FSGS) and a validation set (14 MCD, 14 FSGS). The urinary proteome of the training set was analyzed by two-dimensional differential gel electrophoresis coupled with mass spectrometry. The proteins identified were quantified by enzyme-linked immuno...
Cognitive dysfunction and work productivity in major depressive disorder
Expert Review of Pharmacoeconomics & Outcomes Research, 2016
Major depressive disorder (MDD) is strongly associated with poor work-related outcomes. Cognitive... more Major depressive disorder (MDD) is strongly associated with poor work-related outcomes. Cognitive dysfunction is prevalent in MDD, and research supports a correlation between greater depression severity and more pronounced cognitive deficits, which frequently persist after remission. Given the prevalence of cognitive dysfunction, and the humanistic and economic impact of occupational impairments in individuals with MDD, the relationship between cognitive dysfunction in MDD and work-related outcomes requires characterization. A selective review of the literature was conducted to better understand and further highlight this relationship. Expert commentary: Although current evidence is limited, MDD-related cognitive dysfunction may have a direct negative impact on work productivity. Presenteeism is the key outcome impacted by cognitive deficits in MDD. Additional well-designed prospective observational research may clarify how cognitive dysfunction influences the MDD-work productivity relationship. Use of reliable, valid, and sensitive measures of cognitive functioning and work productivity in MDD is warranted.
Journal of Nutritional Health & Food Science, 2016
Background: Relatively faster initial weight loss may enhance participant motivation to adhere to... more Background: Relatively faster initial weight loss may enhance participant motivation to adhere to a longer-term weight reduction or maintenance plan and overall healthier lifestyle. The Special K Challenge TM is a portion-controlled, 2-week program that recommends replacement of two meals per day with ready-to-eat cereal and incorporation of portion-controlled snacks, fruits, and vegetables to help participants either begin a weight loss program or attain short-term weight loss for ongoing weight maintenance efforts. The objective of this meta-analysis is to examine the effects of a shortterm weight loss program on body weight and waist circumference in ten trials conducted across seven countries. Methods: Random effects meta-analyses generating weighted mean differences in body weight and waist circumference from baseline to 2-weeks (within-group analyses) and comparing intervention to control, where applicable. Results: The Special K Challenge TM intervention resulted in statistically significant weighted mean reductions in body weight (-1.61 kg, 95% CI:-1.85,-1.37) and waist circumference (-2.19 cm, 95% CI:-2.72,-1.66) in the within-group analyses. Compared to the control group, the Special K Challenge TM intervention resulted in a statistically significant decrease in body weight (-1.43 kg, 95% CI:-2.10,-0.76) and waist circumference (-1.20 cm, 95% CI:-2.20,-0.20). Two subgroups analyses, one among women only and one by readyto-eat-cereal serving size, were consistent with these findings. Conclusion: Overall, successful short-term weight loss was achieved, demonstrating that a simple, energy-reduced program with calorie-controlled meals and snacks is an effective approach to attain short-term weight loss and reduce waist circumference among overweight individuals.
This study aimed to identify how the process occurs inclusion and exclusion of visually impaired ... more This study aimed to identify how the process occurs inclusion and exclusion of visually impaired people in organizations, considering such disabilities as the most representative of the deficiencies in the country. Despite this fact, the blind professionals are those with the lowest rate of employment in enterprises that opt for people who have so-called "minor deficiencies" to compose its staff. Visually impaired people suffer the stereotype of disability that carry throughout history, even with the presence of the Quota Law. For the construction of the study was a field study, which included semi-structured interviews and participant observation. The conclusion was reached on the inclusion process of the visually impaired, is that this is virtually the discourse of HR representatives of companies, being visible preference for hiring people with disabilities considered "light" despite the number of professional blind available. The stereotype of working disability appears linked to the process of exclusion of the blind, demonstrates that occur due to ignorance about the visually impaired. New constructions were found, as the stereotype originated from the blind and also the direction major institutions that have for the development of the visually impaired, which can significantly affect how they relate to the seers.
Race/ethnic disparities in discharges from all US community, non-rehabilitation hospitals for respiratory syncytial virus among children one year or younger and the possible role of healthcare access
Cómo reconocer y tratar la ansiedad en el gato
Argos Informativo Veterinario, 2010
Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohorts (391.1)
The Faseb Journal, Apr 1, 2014
Replacement of caloric sweeteners with lower- or no-calorie alternatives may facilitate weight lo... more Replacement of caloric sweeteners with lower- or no-calorie alternatives may facilitate weight loss or weight maintenance by helping to reduce energy intake; however, past research examining low-calorie sweeteners (LCSs) and body weight has produced mixed results. The objective was to systematically review and quantitatively evaluate randomized controlled trials (RCTs) and prospective cohort studies, separately, that examined the relation between LCSs and body weight and composition. A systematic literature search identified 15 RCTs and 9 prospective cohort studies that examined LCSs from foods or beverages or LCSs consumed as tabletop sweeteners. Meta-analyses generated weighted mean differences in body weight and composition values between the LCS and control groups among RCTs and weighted mean correlations for LCS intake and these parameters among prospective cohort studies. In RCTs, LCSs modestly but significantly reduced all outcomes examined, including body weight (-0.80 kg; 95% CI: -1.17, -0.43), body mass index [BMI (in kg/m²): -0.24; 95% CI: -0.41, -0.07], fat mass (-1.10 kg; 95% CI: -1.77, -0.44), and waist circumference (-0.83 cm; 95% CI: -1.29, -0.37). Among prospective cohort studies, LCS intake was not associated with body weight or fat mass, but was significantly associated with slightly higher BMI (0.03; 95% CI: 0.01, 0.06). The current meta-analysis provides a rigorous evaluation of the scientific evidence on LCSs and body weight and composition. Findings from observational studies showed no association between LCS intake and body weight or fat mass and a small positive association with BMI; however, data from RCTs, which provide the highest quality of evidence for examining the potentially causal effects of LCS intake, indicate that substituting LCS options for their regular-calorie versions results in a modest weight loss and may be a useful dietary tool to improve compliance with weight loss or weight maintenance plans.
Revista Latente Revista De Historia Y Estetica Del Audiovisual, 2007
Más de treinta años y otras tantas publicaciones avalan a Gustavo Gili como una de las más import... more Más de treinta años y otras tantas publicaciones avalan a Gustavo Gili como una de las más importantes editoriales españolas que se han preocupado por la Fotografía. A través de esta reseña podrá recorrerse el camino seguido por la editorial, desde la primera obra dedicada al medio fotográfico, hasta sus últimas publicaciones en esta línea.
My dissertation explains the extent to which electoral institutions and declining political party... more My dissertation explains the extent to which electoral institutions and declining political party competition precipitated a steep decline in U.S. turnout after 1896 from which the nation never recovered. Turnout dropped from 83 to 66 percent in less than ten years. This is a persistent puzzle in political science because data limitations have stymied empirical assessment of existing theories. Using original datasets on nineteenth century voter registration laws and records on political gambling on presidential elections from 1880 to 1916, I test the hypothesis that the shift in electoral behavior was a function of registration reforms and declining competition. I find that registration laws and political competition modestly explain the decline. Registration reforms explain one percent of the seventeen point turnout drop, and the combined effect of registration and declining competition is approximately two to three percentage points of the drop. I also found that the effect of registration are conditional on immigration, the effect is stronger in states with higher immigrant populations. For the most part, political party competition had a positive effect on turnout in the expected direction. In states remaining competitive after 1896, the long-term average effect of competition on turnout was an increase of about 14 percentage points. To validate this argument, I use election-betting data to create a measure of the public's perception of electoral competition in the states. My findings indicate that highly informed individuals accurately predicted election outcomes, which suggests the public was aware of the electoral competitiveness of presidential elections in the states. This means that perceptions about the electoral competitiveness of races likely influenced voters' decisions to participate. My dissertation advances our empirical and theoretical understanding of the interaction between institutions and political behavior and helps to inform the current debate on the potential implications that contemporary legal reforms in election laws might have on voter participation in America.
Uploads
Papers by Vanessa Perez