pinar yurdakul

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Papers by pinar yurdakul

[Immunopathogenesis of Leishmania infections]

Mikrobiyoloji bulteni, 2005

Leishmaniasis represents a complex of diseases with a clinical and epidemiological diversity. Lei... more Leishmaniasis represents a complex of diseases with a clinical and epidemiological diversity. Leishmaniasis remains a severe public health problem and its burden is increasing. The disease is caused by a parasite belonging to the genus Leishmania. Approximately 350 billion people in 88 different countries are thought to be infected with Leishmania spp. Clinical forms of leishmaniasis are particularly diverse representing different diseases: visceral (VL), cutaneous (CL), diffuse cutaneous (DCL) and muco-cutaneous (MCL) leishmaniasis. Being the most important determinant not only cellular immunity plays the essential role in the control of leishmaniasis, but the virulence, tropism and pathogenicity that is modulated by environmental and genetic factors of their mammalian hosts and sandfly vectors, are the key interactions. These eukaryotic pathogens have evolved with the vertebrate immune system and typically produce long lasting chronic infections. A critical step in their host inte...

Kordon Kanı Bankacılığı ve Kordon Kanı Nakilleri

Turkiye Klinikleri Journal of Hematology Special Topics, 2018

Impact of mesenchymal stromal cells on in vitro growth of fresh human myeloma plasma cells and on autologous/cord blood NK cell Mediated Cytotoxicity

Cytotherapy, 2018

Ankara Üniversitesi Kordon Kanı ve Kök Hücre Bankası: hizmet ve alt yapı devamlılığı projesi

Bu proje ile Devlet Planlama Teskilati “AU Kordon Kani, Kan ve Kok Hucre Bankasi” adli 2009 da k... more Bu proje ile Devlet Planlama Teskilati “AU Kordon Kani, Kan ve Kok Hucre Bankasi” adli 2009 da kamu alt yapi projesi kapsaminda kurulan AUTF Akraba Disi Doku Bankasi-Gonullu Verici merkezi ile Kordon Kani Bankasi hizmet ve faaliyetlerinin devam edebilmesi, gereksinimlerinin karsilanmasi hedeflenmistir. DPT destegi oncesi mevcut kosullarda baslatilan bu yapilanma once DPT daha sonra BAP proje kapsaminda uluslararasi standartlarin gerektirdigi kosullara kavusarak kordon kani bankaciligi icin gerekli olan Good Manufacturing Practice (GMP) ile uyumlu alt yapisini olusturmustur. 8-9.02.2011 tarihinde Il Saglik Mudurlugu ve Saglik Bakanligi Teftis Kurulu GMP mufettisleri tarafindan yerinde denetlenerek Saglik Bakanligi Tedavi Hizmetler Genel Mudurlugunde Ulusal Kordon Kani Kurulunun degerlendirmesi sonucunda 13/07/2011 da ruhsata uygun bulunmustur.. DPT projesi ile 2010 yili sonuna kadar sarf malzemelerinin cogu, Eylul 2011 e kadar yetecek sivi azot takviyesi, 2011 yili Ekim sonuna ka...

A Preliminary Analysis of Inherited Immune Checkpoint Control in Multiple Myeloma: Relative Frequency of Inhibitory or Activating Type Killer Immunoglobulin like Receptors and Their Cognate Ligands HLA-C1 and -C2

Blood, 2017

Ex Vivo Expansion of Human Umblical Cord Blood Hematopoietic Stem Cells (HSC) with Valproic Acid or Notch-Ligand +/− Fibronectin

Cytotherapy, 2016

Hematopoietik Kök Hücre Nakillerinde Uygun Verici Seçimi

Turkiye Klinikleri Journal of Immunology Allergy Special Topics, 2013

EX VIVO Expansion of Human Cord Blood: Comparison of Enhancers

Biology of Blood and Marrow Transplantation, 2016

We conducted a retrospective analysis of cellular components of bone marrow graft for CD3+ T, CD3... more We conducted a retrospective analysis of cellular components of bone marrow graft for CD3+ T, CD34+ and Natural killer (NK) cells and their relationship on survival in 64 highrisk Acute Lymphocytic Leukemia (ALL) patients who received Hematopoietic stem cell transplant (HSCT), 35 from matched sibling donors and 29 matched unrelated donors from the year of 2000 to 2013. The grafts contained a median CD34+ cells dose of 4.8 x 10 6 /kg (range 0.8-14x10 6 /kg), CD3+ T cells 3.6x10 7 /kg (range 1.1-36.9x10 7 /kg), and NK cells 0.8 x 10 7 /kg (range 0.07-20.6 x 10 7 /kg). The median days for absolute neutrophil count engraftment were 24 (range 14-100) and for platelet 28 days (range 14-180). We conducted a point-biserial correlation examining CD3 + cells with likelihood of survival and relapse. Results showed that ALL patients who received higher CD3+ cells were more likely to survive than those patients with lower CD3 + cells (p¼0.031). Additionally, we found that the positive effect of CD3+ cells was noted with a minimum cell dose of 2.2x10 7 /kg which was associated with better survival without relapse and was statically significant with p value of 0.022. However, we were unable to demonstrate any significant impact of NK cells contents of the graft on survival or relapse (p ¼ 0.257 and 0.722 respectively). In conclusion, this study showed a positive correlation between CD3+ T cells dose in bone marrow graft and survival post-transplant with a minimal cell dose of 2.2x10 ˇ 7 /kg

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[Ecological factors for host tissue colonization]

Mikrobiyoloji Bulteni, Feb 1, 2002

The first stage of microbial infection is colonization; the establishment of the pathogen at the ... more The first stage of microbial infection is colonization; the establishment of the pathogen at the appropriate portal of the entry. Organisms that have the ability to colonize host tissues, have usually developed tissue adherence mechanisms and some ability to overcome or withstand the constant pressure of host defense mechanisms. There are namely 3 adaptations that are important for bacteria to colonize human hosts: Coaggregation, osmo-adaptation, acid tolerance and resistance. In this review article, these adaptation mechanisms have been discussed under the light of literature.

Predominance of hospital-associated MRSA among cystic fibrosis patients in a Turkish reference cystic fibrosis centre

Journal of Chemotherapy, Nov 12, 2013

Methicillin-resistant Staphylococcus aureus (MRSA) strains are the major causative agents of nume... more Methicillin-resistant Staphylococcus aureus (MRSA) strains are the major causative agents of numerous hospital- and community-acquired infections. Increasing prevalence of MRSA in cystic fibrosis (CF) populations is reported all over the world. Although there are papers reporting the prevalence and genetic backgrounds of MRSA isolates from different settings in Turkey, there is no information regarding the situation in the CF community. This study was conducted to characterize the MRSA strains recovered from CF patients followed-up at a Turkish reference CF centre. Microbiological testing of isolates was performed via conventional microbiological techniques. Molecular characterization of MRSA isolates was carried out by SCCmec typing by multiplex PCR and PVL gene determination. Among a total of 604 CF patients included in the study, 325 patients were found to harbour S. aureus (53.8%). Of those 325 patients, 24 were positive for MRSA during their follow-up (7.4%). Thirty-two MRSA isolates from these patients were chosen for further assessment of molecular characteristics. Twenty-six MRSA isolates exhibited a pattern like SCCmec type III (81.2%) and six consecutive MRSA isolates of a single patient revealed SCCmec type IV (18.7%). Our findings definitely support the need for further surveillance studies for CF-MRSA strains and highlight the need for infection control measures in the setting of CF centres.

Selection of Donors for Hematopoietic Stem Cell Transplantation

Allogeneic hematopoietic stem cell transplantation (HSCT) from HLA identical siblings is the most... more Allogeneic hematopoietic stem cell transplantation (HSCT) from HLA identical siblings is the most successful and life saving therapeutic approach for patients with blood and immune system disorders. Bone marrow, peripheral blood and cord blood are the major sources of HSCT, cord blood being used increasingly in clinical practice. Although different stem cell sources may have various advantages and disadvantages, main goal of HSCT is to obtain sustained engrafment without inducing graft versus host disease (GVHD), preventing relaps and providing immune reconstitution. The main distinction between HSCT and other organ & tissue transplantations is the fact that donor immune system cells are transferred to host along with stem cells. These immune factors play significant roles in engrafment capacity, graft versus leukemia effect and immune reconstitution. For patients without an HLA matched sibling, HLA compatibility becomes the main prerequisite for finding an unrelated HSC donor. When...

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Görduysus M, Tuncel B, Nağaş E, Ergünay K, Yurdakul P, Torun ÖY, Ergüven S, Görduysus Ö. Antimicrobial Effects of Various Endodontic Irrigants on Selected Microorganisms. Cdr 2011:35(1): 41-46

1. P.Yurdakul, A.S.Ozgu Erdinc, Handan Karakaya, S.Ozkul, K.Dalva, Doruk Katlan, F. Çelebi, M.S.Beksac, M.Beksac. “Impact Of Maternal Thrombophilia On Donated Umblical Cord Blood Cellular Content”, 5-8 June 2013, 11. International Cord Blood Symposium, San Francisco, USA

S.Ozkul, F.Akal, A.Basalp, P.Yurdakul, K.Dalva, M.Beksac “Impact of Donor and Cord Blood Unit Numbers on Finding a Suitable Match Within a Small Sized Registry.” National Marrow Donor Program 2012 Council Meeting, 2-7 November 2012, Minneapolis, USA

AUTF Kordon Kani Bankasi (KKB)’na Eylül 2013-Haziran 2014 Döneminde Başvuran Bağışçı Annelerde ve Bebeklerinin Kordon Kanı Ünitelerinde HbsAg, Anti-HBs ve Anti-HBc IgG Varlığının Araştırılması ve Anne Bağışıklık Tipine Göre Antikor Geçiş Düzeylerinin Karşılaştırılması