React4life

Knowledge transfer and scientific collaboration are at the heart of innovation. We are happy to host Giuseppe Valenzano, PhD student at Università Cattolica del Sacro Cuore, who is joining our lab for a training period focused on the #MIVO platform and its potential applications in the study of autoimmune diseases affecting the central nervous system. This experience is part of his doctoral programme, co-funded by React4Life, with the aim of transferring new expertise, methodologies, and experimental approaches back to his research laboratory while strengthening the connection between academia and industry. By supporting the training of young researchers and promoting scientific exchange, we contribute to the development of more physiologically relevant models for biomedical research and to the advancement of innovative approaches in disease modelling. A glimpse from Giuseppe’s training at our laboratory 👇

Scaling organ-on-chip research requires higher throughput without compromising biological relevance. As advanced in vitro models become increasingly integrated into drug discovery and translational research, researchers need experimental platforms that can efficiently support larger studies while maintaining physiological relevance and reproducibility. The MIVO-based Tokyo24 Platform enables up to 24 parallel millifluidic experiments, combining increased throughput with the key advantages of the #MIVO technology: ✔ Dynamic perfusion under controlled flow conditions ✔ High experimental reproducibility across multiple conditions ✔ Clinically relevant tissue dimensions ✔ Compatibility with standard laboratory workflows and analytical techniques Whether performing compound screening, comparative studies or biological replicates, Tokyo24 supports scalable experimental design while preserving the physiological complexity required for human-relevant in vitro research. Learn more 👉 https://lnkd.in/dTWYHixp #OrganOnChip #DrugDiscovery #Millifluidics #NAMs

Studying chronic conditions requires more than acute responses. Many in vitro models are optimized to capture early biological responses, but complex diseases are shaped by dynamic processes that evolve over time. Investigating disease progression and long-term therapeutic effects requires experimental systems capable of maintaining tissue functionality and physiological relevance beyond short-term assays. The #MIVO platform enables long-term dynamic 3D tissue cultures under controlled flow conditions, supporting the study of time-dependent biological mechanisms, chronic responses, and sustained treatment effects. For example, long-term dynamic models are becoming increasingly important for investigating how the intestinal barrier responds to prolonged inflammatory stimuli and how therapeutic interventions modulate tissue responses over extended periods. By extending experimental windows, the MIVO® platform provides deeper insights into human biology and supports the development of more predictive human-relevant models for research and therapeutic evaluation. #DrugDiscovery #TranslationalResearch

A 3D model is not defined only by its structure. In drug discovery, biological relevance depends on the ability to reproduce the complex interactions that drive human tissue behavior. Cells continuously respond to their surrounding environment: extracellular matrix composition, spatial organization, cell-cell communication, and dynamic transport processes all influence biological outcomes. 3D models provide a more representative framework to investigate these mechanisms, but maintaining physiological relevance requires recreating not only tissue architecture, but also the dynamic conditions that shape cell responses. The #MIVO platform integrates 3D biological models with controlled perfusion, creating experimental systems that better capture key aspects of human physiology. For preclinical research, improving the biological context means generating data that can support more informed decisions throughout the drug development process. #DrugDiscovery #TranslationalMedicine

We are pleased to be part of the "One Health in Action" webinar series, organized by the Università degli Studi di Genova PhD Programmes and Centro 3R to support the training of the next generation of researchers. On July 17th, our team will present how #MIVO organ-on-chip technology, enables the development of advanced 3D tumor models and multi-organ systems to better reproduce tumor progression, immune cell infiltration, and therapeutic response in vitro. Supporting the education of young scientists and sharing innovative approaches to biomedical research is something we deeply value, and we are grateful for the opportunity to contribute to this scientific programme. 📅 July 17th, 2026 | 14:30–16:30 CEST 💻 Microsoft Teams 🎓 Participation is free and open to PhD students and professionals. To receive the meeting link, please contact Anna Maria Bassi at anna.maria.bassi@unige.it. We look forward to meeting you online! #CancerResearch #3DTumorModels #InVitroModels

An inspiring first day at the 6th Workshop of the Tumor Biochemistry Group in Bologna, "Untangling the Molecular and Metabolic Networks in Cancer Progression." The workshop is bringing together researchers from different fields to discuss the complex molecular and metabolic mechanisms driving cancer progression and the challenges of developing more predictive experimental models. At React4Life, we are pleased to share how #MIVO Cancer-on-Chip models can support cancer research by enabling the study of tumor biology under controlled dynamic conditions, helping researchers better investigate tumor–microenvironment interactions and disease mechanisms in a more physiologically relevant context. We are enjoying the opportunity to exchange ideas, discuss emerging challenges in oncology research, and connect with scientists working towards more predictive approaches in cancer studies. Looking forward to the discussions continuing tomorrow. #React4Life #MIVO #CancerOnChip #OrganOnChip #CancerResearch #TumorMicroenvironment #3DCellCulture #TranslationalResearch

Just published | Dynamic modeling of tumor metabolism in physiologically relevant conditions Understanding metabolic regulation within the tumor microenvironment requires experimental systems capable of preserving spatial and temporal control over nutrient availability. Static 3D cultures are limited by diffusion-driven gradients, which can distort the metabolic state of tumor constructs and reduce the physiological relevance of experimental readouts. In this study, the MIVO® platform was used to introduce controlled dynamic perfusion within 3D tumor models, enabling a more physiologically relevant distribution of nutrients and soluble factors across the tissue. This configuration allows the investigation of how variations in metabolic conditions, such as nutrient restriction, modulate tumor cell responses under transport dynamics that better approximate in vivo environments. Importantly, the ability to decouple diffusion constraints from cellular responses provides a more robust framework for interpreting metabolism-dependent effects in cancer biology. #CancerResearch #TumorMicroenvironment #MIVO #TranslationalBiology

The recent Mac4Me Horizon Europe MSCA Doctoral Network consortium meeting and training session provided an important opportunity for the network's doctoral candidates to present their research, exchange ideas, and receive feedback from academic and industrial partners. As part of the Mac4Me programme, our MSCA Doctoral Candidate Brett Vega presented the progress of his PhD project at React4life, where he is developing advanced Organ-on-Chip models using the MIVO® platform to investigate metastatic cancer progression. A key focus of Brett's research is the development of a blood–brain barrier #BBB model, integrating endothelial cells together with brain-supporting cells under dynamic culture conditions. The goal is to create a more physiologically relevant in vitro system to study how metastatic tumour cells interact with brain-like vascular barriers and to support the investigation of mechanisms involved in metastatic dissemination. The training sessions and scientific discussions held in Nottingham offered valuable input to further refine the experimental approach, reinforcing the shared objective of improving in vitro models for metastatic cancer research and supporting the investigation of macrophage-mediated mechanisms within the tumor microenvironment. https://lnkd.in/dYR_E9qp

Reproducibility remains one of the greatest challenges in 3D cancer research. Predictive results require not only robust biological models, but also experimental conditions that faithfully replicate human physiology. Join our upcoming webinar with PromoCell to discover an integrated workflow that addresses both challenges: from the generation of uniform, matrix-free tumorspheres to their implementation in dynamic Cancer-on-Chip systems. By combining standardized 3D tumor models with #MIVO technology, researchers can recreate key features of the tumor microenvironment, including interstitial fluid flow and shear stress, enabling more predictive studies of tumor progression, invasion, and drug response. Discover how reproducible spheroids and physiologically relevant culture conditions can help bridge the gap between conventional in vitro assays and in vivo outcomes. 🔗 Save your seat: https://lnkd.in/exunENwq #CancerModeling #3DCellCulture

The EUROoCS Annual Meeting 2026 in Braga brings together a broad international community of scientists, clinicians, industry experts, regulators, and policy stakeholders working at the forefront of organs-on-chip and microphysiological systems (#MPS). This year, key topics include disease and multi-organ systems, organ-on-chip technologies, PK/PD modelling, biofabrication and biomaterials, as well as ongoing efforts in standardisation and toxicity assessment. The meeting represents an important opportunity to exchange perspectives on how organ on chip systems like #MIVO can further improve the predictivity and translational value of in vitro models in biomedical research and drug development. Come an visit us at📍 Booth 10 in Braga!