Papers by Michael Dellarco
National Children's Study Measuring Environmental Exposures
Considerations for environmental sample storage, laboratory analysis, and results reporting
ISEE Conference Abstracts, 2013
A longitudinal birth cohort study, such as the U.S. National Children’s Study (NCS), presents sev... more A longitudinal birth cohort study, such as the U.S. National Children’s Study (NCS), presents several challenges when designing and implementing environmental sample collection, storage, analysis, ...
From Our Readers
Applied Occupational and Environmental Hygiene, 1995
A Rational Approach to Skin Decontamination
Data access and management in the National Children's Study
The National Children's Study (NCS) includes investigation of basic mechanisms of development... more The National Children's Study (NCS) includes investigation of basic mechanisms of developmental disorders and environmental factors, adverse and protective, that influence health and development processes where environment is defined broadly as physical, chemical, biological, and psychosocial factors. To achieve these objectives a multistage, clustered probability sample design for 100,000 children was developed to ensure that the exposure-outcome relationships identified apply to all of the children in the United States. The probability sample and cluster design provide a means to capture the wide range of exposures with different, often unknown, distributions across the population in the communities selected for study. The size and scope of the study poses considerable and unique challenges for sample collection, data storage, and data analysis. This is addressed through development of a sample management system that governs the site visit structure and content for each study ...
Assessing environmental exposures: State-of-the-art approaches for dust contamination
The National Children's Study Program Office is evaluating the how, when, and where of dust c... more The National Children's Study Program Office is evaluating the how, when, and where of dust collection with the goal of optimizing environmental measurements for assessment in the National Children's Study. Projects are underway to inform study design and these include 1) analyzing the stability over time of environmental contaminants in dust samples; 2) assessing different kinds of dust collection procedures, including participant collection of dust samples; and 3) determining the correlation in dust between pesticides and other environmental contaminants in rural and urban settings while controlling for floor type covering, dust collection method, and lifestyle. Dr. Dellarco is the Program Officer for the National Children's Study, where he serves as the coordinator for environmental monitoring leading the design and development of environmental measurements for application in the National Children's Study. He works within the National Children's Study Program ...
Applied Occupational and Environmental Hygiene, 1994
We have analyzed the maintenance logs maintained by owners of buildings containing asbestos firep... more We have analyzed the maintenance logs maintained by owners of buildings containing asbestos fireproofing and subject to operations and maintenance (O W) programs to evaluate the risk to maintenance personnel from exposure to airborne asbestos. The logs were kept to document protective measures and exposures of maintenance personnel as they performed routine maintenance during the 1991-1992 period. Four of the buildings were commercial and one was a hospital. All exposure monitoring was performed by contract industrial hygienists using the National Institute for Occupational Safety and Health 7400 protocol for sampling; filter analyses were by phase contrast microscopy in certified laboratories. 0 & M programs required modest control measures, including spraying of ceiling tiles with amended water, high efficiency particulate air vacuuming of tile edges before entry and after tile replacement, respirator usage, and careful work; negative pressure containment was not used. A total of approximately 500 personal and area samples were obtained during the period of maintenance work. In one building, personal exposures during electrical/plumbing work ranged from 0.000 to 0.035 fiber/cc (f/cc) > 5 pm in length (average work time of one job was 118 minutes); the 8-hour time-weighted average (TWA) was 1.49 X lo-* f/cc > 3 pm. Personal exposures during cable running were 0.001 to 0.288 f/cc > 5 pm length (average work time of one job was 169 minutes); the 8-hour TWA was 1.67 X 10" f/cc > 5 pm in length. Personal exposures during heating, ventilation, and airconditioning work was 0.000 to 0.077 f/cc > 5pm in length. In this same building, the maximum time any worker spent working above the ceiling was 3.31 percent of his total working time for the period of the log. The TWA for the entire working period covered by the log corrected for this factor was 2.27 X 10-3 f/cc > 5 pm. Exposure results for the other buildings differed little from results cited above. If minimum O&M procedures are followed by knowledgeable, careful workmen, their TWA exposures to asbestos-in-air from asbestos-containing fireproofing while they work above the ceiling are well below the Occupational Safety and Health Administration 8-hour permissible exposure limit for the period of their work.
A computerized bibliographic literature information system for total human exposure monitoring research
ABSTRACT
ACS Symposium Series, 1992
Frontiers in Pediatrics
A challenge for longitudinal studies is combining individual assessments into visits that are sci... more A challenge for longitudinal studies is combining individual assessments into visits that are scientifically logical, not burdensome for participants, well-choreographed, and operationally feasible. The visits then need to be sequenced and spaced to address the scientific goals and generate a data archive that is sufficiently robust and well-documented to support subsequent analyses. This paper summarizes comprehensive multi-disciplinary activities that were coordinated to design the content, format, and structure of the National Children's Study and concurrently serve as a model and resource for other studies.
Harmonization of Exposure Assessment Questionnaires in the Environment and Child Health International Birth Cohort Group
Environmental health perspectives, Sep 19, 2013
Biomonitoring, 2014
Large scale studies of environmental influences on children’s health and development are being pl... more Large scale studies of environmental influences on children’s health and development are being planned or conducted in many places, including Japan, France, Shanghai (China), the United States, and Germany. The objective of these “next generation” studies is to better understand a broad range of environmental and social factors that influence the health and well-being of children. Some of these studies are designed to enroll tens of thousands of children and follow them for many years to investigate the influence of the environment on child growth, development and health. Environment is broadly defined in these studies and includes investigation of chemical, biological, physical and socioeconomic factors. An international group composed of study teams from Japan, France, Shanghai (China), the United States, and Germany has been meeting since 2011 to exchange information and work towards harmonization of processes that would provide the opportunity to compare methods and develop proc...
Influence of Matrix Formulation on Dermal Percutaneous Absorption of Triazole Fungicides Using QSAR and PBPK/PD Models
Epidemiology, 2006
Toward Harmonization of Dermal Absorption Methods for Environmental Health Exposure Assessment
Epidemiology, 2006
Update of the U.S. EPA Guidelines for Exposure Assessment
Epidemiology, 2006
Summary report the Joint WHO/IOMEH Workshop on Human Exposure Assessment in Environmental Health Decision-Making. Sosnowiec, Poland, 19-23 November 1996
Central European journal of public health, 1998
Pediatric Research Using Integrated Sensor Monitoring Systems (PRISMS): Applying Sensor Technology and Informatics to Better Understand Asthma
The Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS) program was launched i... more The Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS) program was launched in 2015 to develop sensor-based, integrated health monitoring systems for measuring environmental, physiological, and behavioral factors in epidemiological studies of pediatric asthma. PRISMS will develop an open platform and associated suite of tools to enable a comprehensive spectrum of biomedical research into chronic diseases in pediatric populations. We describe the PRISMS program goals, operations, and organization, and informatics challenges. Introduction The NIH launched a cross-institute initiative to examine the effects of the environment on children’s health, including the Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS) Program. As part of its mission NIBIB conducts research and development of new bioengineering techniques and devices to improve the detection, treatment, and prevention of disease, including technologies for disease detection and assessmen...
Review Using National and Local Extant Data to Characterize Environmental Exposures in the National Children’s Study: Queens County, New York
from 105 locations across the United States. It will require information on a large number of env... more from 105 locations across the United States. It will require information on a large number of environmental variables to address its core hypotheses. The resources available to collect actual home and personal exposure samples are limited, with most of the home sampling completed on periodic visits and the personal sampling generally limited to biomonitoring. To fill major data gaps, extant data will be required for each study location. The Queens Vanguard Center has examined the extent of those needs and the types of data that are generally and possibly locally available. Data: In this review we identify three levels of data—national, state and county—and local data and information sets (levels 1–3, respectively), each with different degrees of availability and completeness, that can be used as a starting point for the extant data collection in each study location over time. We present an example on the use of this tiered approach, to tailor the data needs for Queens County and to ...
Operational considerations for field data collection of water and dust samples in the home
ISEE Conference Abstracts, 2013
ABSTRACT
Frontiers in Pediatrics, 2021
An important step toward understanding the relationship between the environment and child health ... more An important step toward understanding the relationship between the environment and child health and development is the comprehensive cataloging of external environmental factors that may modify health and development over the life course. Our understanding of the environmental influences on health is growing increasingly complex. Significant key questions exist as to what genes, environment, and life stage mean to defining normal variations and altered developmental trajectories throughout the life course and also across generations. With the rapid advances in genetic technology came large-scale genomic studies to search for the genetic etiology of complex diseases. While genome-wide association studies (GWAS) have revealed genetic factors and networks that advance our understanding to some extent, it is increasingly recognized that disease causation is largely non-genetic and reflects interactions between an individual's genetic susceptibility and his or her environment. Thus,...
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Papers by Michael Dellarco