Papers by Shalmali Pendse
Unveiling the pharmaceutical and therapeutic potentials of Bambusa vulgaris essential oil
Vegetos
Breast cancer is one of the leading cancers in the globe occurring in 12% of women sufferings fro... more Breast cancer is one of the leading cancers in the globe occurring in 12% of women sufferings from various cancers. Lot of research in medical science on breast cancer is going on with researchers finding new molecules or therapies to treat this disease with minimum or negligible side effects. Traditionally, venom of venomous animals has been used to treat various diseases at minute concentrations and has been proved to be an effective therapeutic agent. Venom of viper like snakes has been reported to have therapeutic effect on breast cancer. Malabar pit viper snake, endemic to Western Ghats of India, is being evaluated for the anticancer potential of its venom in current work. Venom is a mixture of many proteins of varying molecular weight and properties. The fractionation and purification of these venom proteins has been carried out to separate the active protein with has anticancer potential. Gel permeation chromatography followed by SDS PAGE analysis indicate the presence of 5 f...
Bacteriocins and Its Applications: An Overview
Bacteriocins have been effective against various diseases and are used as an alternative to tradi... more Bacteriocins have been effective against various diseases and are used as an alternative to traditional antibiotics which in turn can solve a major problem of drug resistance. This review discusses bacteriocins and its applications in disease treatment and as an alternative to antibiotics. They have been classified as per their mode of action into class I, II, III and class IV of which class IV has been excluded from the classification. Nisin is the commercially available bacteriocin in the market, which has been widely used; therefore, its action and application have been elaborated here. Bacteriocins are beneficial to the host since they are naturally added to the foods. A special emphasis has been focused on its potential as an anti-tumour drug candidate due to their low oral toxicity. We have also discussed the other properties of bacteriocins such as biopreservative, as a carrier molecule, its application in packaging, bioengineering etc.
Nuclear Physics News, 2010
delivered a virtual plenary lecture on "Perspectives of non-animal models". He stated that while ... more delivered a virtual plenary lecture on "Perspectives of non-animal models". He stated that while the limitations of animal-based toxicology to predict human health issues are being increasingly recognized, shortcomings of traditional (human) cell culture are also evident. Issues around these include cell identity, differentiation, genetic stability and mycoplasma infection as well as non-homeostatic and non-physiological culture conditions. Large toxicological databases ("big data") and data-mining technologies ("artificial intelligence") now allow predictive computational approaches on a new scale, for example, using automated read-across (RASAR, i.e., read-across-based structure activity relationships). At the same time, the combination of cell culture with bioengineering has led to more organotypic cell culture technologies, such as 3D culture, human stem cell-derived systems, perfusion, co-cultures, combinations with scaffolds and sensors, etc. Increasingly, these approaches are combined to organ-on-chip or even multi-organ human-on-chip solutions. By recreating organ architecture and functionality and homeostasis of the cell environment, these models mirror the physiological situation more closely. The example of the human iPSC-derived mini-brain developed at CAAT illustrates this claim. Combined with an increased mechanistic base of reasoning (e.g., adverse outcome pathway (AOP) concepts, integrated testing strategies (ITS), and evidence-based methods of data evaluation and integration), these are revolutionary changes in how we can assess the biological effects of substances. Dr Christian Pellevoisin, Scientific Director, EPISKIN Academy, Lyon, France, talked about "Medical devices: ISO 10993 series moves to alternative methods". He said that reconstructed human epidermis (RhE) allows validated full or partial replacement of different in vivo assays, is integrated in OECD Test Guidelines, and is used in screening and in support of weight of evidence approaches. Recently, RhE has been adapted to testing biocompatibility of medical devices, monitoring devices, and instruments used in diagnostics. The project conducted under Workgroup 8 (WG8) of the Technical Committee 194 (TC194) for biocompatibility of medical devices aims to replace the in vivo Draize test by an in vitro method using RhE models. The recent outcome of the round robin study with two RhE models in 17 lab
Screening of Phytochemicals as Potential Inhibitors of Breast Cancer using Structure Based Multitargeted Molecular Docking Analysis
Phytomedicine Plus, 2022
Setting the trend for the alternatives movement in India: The Second National Conference of the Society for Alternatives to Animal Experiments-India
ALTEX
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Papers by Shalmali Pendse