Endo45

Two years. Two awards. 💛 More importantly, another reminder that women's health innovation is finally getting the recognition it deserves. We're incredibly proud of our founder, Juliet Oliver, and even prouder of the community that continues to inspire everything we build. This is for every person living with endometriosis. We're just getting started. https://lnkd.in/e3_2HUwp

New research is raising an interesting question about endometriosis the bacteria living in your gut. What if changes in gut bacteria aren't just a consequence of endometriosis — but part of what's helping drive it? In this study, researchers transplanted gut microbes from healthy donors into mice with endometriosis. The result? Lesion volume dropped from approximately 658 mm³ to 167 mm³, while lesion weight fell by a similar amount. What's particularly interesting is how it happened. Researchers found that improving the gut microbiome increased acetate — a beneficial compound produced by gut bacteria — improved gut barrier function, altered immune signalling, and was associated with significantly smaller lesions. This adds to a growing body of research suggesting the microbiome may be more than a bystander in endometriosis. Taken together, the evidence is starting to point toward a gut–immune–endometriosis connection that researchers are only beginning to understand. ⚠️ Important: This was an animal study. It does not mean faecal microbiota transplants cure endometriosis, and human clinical trials are still needed. But it does raise an important question: Could improving gut health help influence disease progression in some people with endometriosis? 👉 Comment "GUT" for a deeper understanding and to access the tools we use in Endo45 to support gut health and microbiome diversity. . . . . References: Xu Y et al. 2025. Gut Microbiota-Derived Acetate Ameliorates Endometriosis via JAK1/STAT3-Mediated M1 Macrophage Polarization. Am J Reprod Immunol. Ni Z et al. 2023. Gut microbiota contributes to the development of endometriosis. Cell Death Discovery. Chadchan SB et al. 2021. Gut microbiota-derived short-chain fatty acid n-butyrate protects from endometriosis. Life Science Alliance. Li X et al. 2026. Fluvastatin alleviates endometriosis by modulating gut microbiota and metabolite profiles. Frontiers in Microbiology.

📢 Big month for Endo45 ✈️🇳🇿➡️🇺🇸 Our Founder, Juliet Oliver, is headed to the American College of Obstetricians and Gynecologists (ACOG) Annual Clinical & Scientific Meeting in Washington D.C. 🎉 Because too many patients are still stuck in the “wait and see” gap — waiting months or years for answers while trying to manage pain, fatigue, heavy bleeding, fertility challenges, and daily life. Endo45 exists to help bridge that gap. We’re incredibly excited to be bringing that conversation to ACOG and connecting with clinicians, researchers, and women’s health leaders working to improve care globally. 💬 If you’re heading to ACOG, make sure to drop Juliet a message — she’d love to connect in person. Let’s build better care, not just better awareness. #ACOG2026 #Endometriosis #WomensHealth #DigitalHealth #HealthInnovation #OBGYN #PelvicPain #FemTech #Endo45 https://lnkd.in/e_uvXdT6

Being told “there’s no cure” shouldn’t be the end of the story. Our founder Juliet Oliver recently sat down with Anne Chang to talk about the real gap in endometriosis care — what happens after diagnosis, when you’re left to figure it out alone. This is exactly why we built Endo45. If you’re navigating endo or adeno — this conversation on the Spill Her Tea podcast is for you 💛 https://lnkd.in/eheKMGYN

If I were starting a health tech company again, I’d do this from day one — not three years later. I’d fully back my experience and my product to be accepted by the medical profession… even though I’m not “from health.” I spent my entire systems engineering career confidently going head-to-head with CEOs — clearly seeing where better outcomes could be achieved. But when I built my own brand? That belief disappeared. I shrank myself. I questioned whether a decade of lived experience, research, and practitioner support was “good enough” to belong in the medical world. Now I can see it clearly: It wasn’t a capability gap. It was a confidence gap. A fear of being told it wasn’t good enough. Today, thousands of #endometriosis patients worldwide are seeing a 25% improvement in quality of life within 45 days using Endo45. And what the app delivers is simple: The evidence-based strategies GPs don’t have time to support in a 15-minute consult — but that are essential to actually managing symptoms. That’s what makes Endo45 not just credible… but necessary. A tool to help unburden a #primarycare system constrained by limited diagnostics, short consults, and long specialist wait times for pelvic pain patients. So, with the support of Spark Health, we’re heading to the #WONCA World Rural Health Conference 2026 — four days of sharing what’s possible when we start to close the gap. If you’re there, come find me at our stand — I’d love to connect. Big shout out to Hauora Taiwhenua Rural Health Network for creating a transformative event for the health of our rural communities globally. #Endometriosis #WomensHealth #DigitalHealth #HealthInnovation #PrimaryCare #WONCA #RuralWONCA26 #RuralHealth #HealthInnovation #GlobalHealth #HealthPartnerships

🚨 Gynaecologists, endo specialists & pelvic pain clinicians --> What happens once patients finally reach you? In New Zealand, many GPs report low confidence in managing pelvic pain and endometriosis — and patients experience delayed referrals and fragmented first-line care*. From early conversations, one pattern keeps coming up: Patients need more support than a consult can hold. • onboarding into a complex condition • education gaps → delayed decisions • constant follow-up questions • navigating fragmented care • managing symptoms between visits ➡️ This often becomes unbillable time and scheduling pressure ➡️ And patients can still feel unsupported — waiting months between appointments I’m hearing that clinicians are being asked to manage a complex chronic disease - inside a system built for short, episodic care. Is this true where you are? 💬 Keen to hear from you: - What’s the biggest non-clinical demand patients place on your practice? - Where does the system break down most? - Have you seen anything that actually helps bridge this gap? If you’re open to sharing more, I’d really value a quick conversation or comment someone you know would. 👉 Leave a comment below or register your interest here: https://lnkd.in/eJyDEfd8 (This is purely research — listening and learning.) Kerry Krauss MD FACOG, Dr. Roopan Gill, Devon Evans, BScH, MD, MPH, FRCSC, FACOG, Karla Loken DO OBGYN FACOOG, Heather Guidone, BCPA, #Endometriosis #WomensHealth #Gynecology #PelvicPain #DigitalHealth *Ellis et al., 2024 — Survey of GP perspectives on endometriosis diagnosis and referral pathways (Health Expectations)

New research is raising an interesting question about endometriosis and GLP-1. A recent study found that women with endometriosis had lower GLP-1 levels in peritoneal fluid — and lower GLP-1 was associated with altered macrophage activity. Pointing to something researchers are increasingly recognising: 👉 Endometriosis may involve immune and metabolic dysfunction — not just reproductive pathology. GLP-1 is typically discussed in blood sugar and weight regulation. But it also influences: • immune cell activity • inflammatory signalling • oxidative stress • tissue repair All systems relevant to endometriosis. So the question becomes: If GLP-1 signalling is altered — What does that tell us about the disease environment, or the immune-metabolic connection? 💬 Keen to hear from clinicians and researchers: - Do you see this as mechanistically meaningful, or more likely incidental? - Have you observed any changes (positive, negative, or neutral) in endometriosis patients using GLP-1 therapies in practice? - Where, if anywhere, do you think this line of research could realistically lead? 💡 Whole-body conditions require whole-body models. It’s encouraging to see research beginning to reflect that complexity. 📚 Primary references: Wu et al., 2022 — GLP-1 levels and macrophage activity in endometriosis (Frontiers in Endocrinology) Lee & Jun, 2023 — GLP-1 receptor agonists in immune modulation (Frontiers in Immunology) Drucker, 2018 — Mechanisms of GLP-1 (Cell Metabolism) Wan & Sun — GLP-1 and macrophage polarization (Experimental Therapeutics) #Endometriosis #WomensHealth #Immunology #Metabolism #GLP1 #Gynecology #HealthResearch #DigitalHealth #SystemsBiology

New research is prooving endometriosis isn’t just painful. It’s financially devastating. A newly released national cost-of-illness study from New Zealand estimates that endometriosis can cost ~$1.96 int. over a person’s working life. 💸 That’s not a typo. Before jumping to conclusions, here’s the key reframe 👇 This isn’t about individual spending choices or “managing better.” What it shows is something much bigger: 💡 Systemic cost from a systemic disease. Across countries, studies consistently find that most endometriosis-related costs come from: • missed workdays • reduced productivity • lost income • delayed diagnosis • repeated surgeries, scans, and medications • long-term allied & multimodal care In other words: 🏥 medical systems 💼 workplaces ⏳ diagnostic timelines weren’t built for chronic, whole-body disease. So when you feel like your body is “too expensive to maintain,” There is a real economic driver behind that experience — and it isn’t personal failure. 💛 Whole-body diseases create whole-life costs. And science is finally starting to measure what patients have always carried. 💬What has endometriosis cost you — financially, emotionally, or professionally? . . . 📚 Primary citations • Tewhaiti-Smith et al., Diseases (MDPI), 2024 — New Zealand national cost-of-illness study • Ellis et al., Frontiers in Global Women’s Health, 2022 — Global economic burden of endometriosis • Swift et al., European Journal of Public Health, 2024 — Europe: costs & diagnostic delay • Soliman et al., Journal of Managed Care & Specialty Pharmacy, 2018 — United States costs • Levy et al., Journal of Obstetrics & Gynaecology Canada, 2011 — Canada costs • Yuspa, Asian Journal of Health Research, 2024 — Systematic review & global gaps . . . endometriosis, endo support, endometriosis support, endo pain, endometriosis awareness, endometriosis awareness month, endo awareness month, endo sucks, endo warrior, endometriosis warrior, endo belly, endo flare, chronic pelvic pain, endometriosis UK, endometriosis Australia, endo community, living with endometriosis, endo strong, endo sisters, chronic pain relief, endo diet, chronic illness life, chronic illness support, invisible illness awareness

New research is changing how we understand #endometriosis and #ADHD. A large-scale population study showed that people with endometriosis are almost twice as likely to have ADHD, and the association goes both ways. 🔄 Share with someone who's been told "you're just anxious." Before jumping to conclusions, here’s the key reframe 👇 This does not mean one condition causes the other. What it does suggest is something we've long felt: 💡 Shared biology. Researchers are finding overlap in the systems that regulate: • chronic inflammation • immune and hormonal signalling • estrogen–dopamine interactions • shared genetic risk pathways In other words: 🧠 brain 🧬 hormones 🛡️ immune system don’t operate in isolation — and neither does endo. So when focus issues, emotional dysregulation, anxiety, or burnout are dismissed as “just psychological,” this research offers a very different explanation. There may be a real biological driver behind what you’re experiencing. 💛 Whole-body conditions need whole-body understanding. And #endoscience is finally starting to reflect that. 💬 Do you have ADHD and endo or adenomyosis? . . . 📚 Primary citations • Chen et al., Human Reproduction, 2024 — Nationwide population-based study showing a bidirectional association between endometriosis and ADHD • Kvaskoff et al., The Lancet Regional Health – Europe, 2023 — Endometriosis as a systemic inflammatory disease with neurological and immune implications • Mahajan et al., Nature Genetics, 2018 — Shared genetic architecture across neuropsychiatric and immune-mediated conditions • Large et al., Biological Psychiatry, 2021 — Estrogen modulation of dopamine signalling and executive function • Gore et al., Endocrine Reviews, 2015 — Early-life exposure to endocrine-disrupting chemicals and long-term neuroendocrine effects