John Stein

University of Oxford, Physiology, Anatomy & Genetics, Faculty Member

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Papers by John Stein

Key words Visual feedback · Motor control · Action

Effects of visual feedback on manual tracking and action tremor in Parkinson’s disease

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Printed in Great Britain REVIEW ARTICLE REPRESENTATION OF EGOCENTRIC SPACE IN THE

This is the final published version of this article; it is available at:

Exp Brain Res (1998) 123:387–396 © Springer-Verlag 1998 RESEARCH ARTICLE

Microstimulation of movements from cerebellar-receiving, but not pallidal-receiving areas of the ... more

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Generated Limb Movements Thalamus During Visually Triggered and Internally Temporary Inactivation in the Primate Motor

Targeting the Subthalamic Nucleus

Stereotactic and Functional Neurosurgery, 2001

The small size and surrounding neuronal structures and fibre tracts make the STN a difficult ster... more The small size and surrounding neuronal structures and fibre tracts make the STN a difficult stereotactic target. In this article we present the technique used by us to target the STN. Our combined experience from two centres comprises 18 lesions and 27 stimulator implants in the STN. Our criteria for patient selection and the use of MRI, frame-on CT and volumetric image fusion are presented. The role of a movement disorder specialist neurologist in the operating theatre, local field potential recording, impedance monitoring, macrostimulation, post-operative CT/MRI and test stimulation are detailed.

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P 443 Fixation instability in dyslexics

Vision Research, 1995

To establish linkage for families with autosomal dominant optic atrophy and to determine whetlier... more To establish linkage for families with autosomal dominant optic atrophy and to determine whetlier there is any evidence for genetic heterogeneity. WHODS After examination patients were entered into the study if they fulfilled the criteria for autosomal dominant optic atrophy of onset in the first decade, blue-yellow dyschromatopsia and characteristic optic nerVe pallor.

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Differences in Visuospatial Judgement in Reading-Disabled and Normal Children

Perceptual and Motor Skills, 1996

Both visual and verbal impairments have been reported in two independent streams of research into... more Both visual and verbal impairments have been reported in two independent streams of research into the etiology of dyslexia or reading-disability. To address the question of the presence of either abnormality in reading-disabled children, visuospatial and phonological ability were assessed and contrasted in 39 Normal and 26 Reading-disabled children. To assess whether these deficits are unique to dyslexia, scores were also compared to those of a group of 12 Poor Readers (“garden-variety” backward readers with low IQs). The Benton Judgement of Line Orientation Test was used for its simplicity and clinical reliability: Reading-disabled subjects performed significantly worse than Normal readers (but similar to Poor Readers). Reading-disabled subjects performed worse for lines in the left-hemifield compared to Normal subjects and also had a greater tendency to scan the task in reverse order (left-to-right) from the usual right-to-left scanning pattern observed in the Normal group when pe...

Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK

Journal of Medical Genetics, 2004

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Visual magnocellular deficits in dyslexia

Brain, 2003

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Towards the Physiology of Visual Dyslexia

Dyslexia: Neuronal, Cognitive & Linguistic Aspects, 1982

Summary The visual processes necessary for reading take place in the left hemisphere. Yet visual ... more Summary The visual processes necessary for reading take place in the left hemisphere. Yet visual verbal material can be delivered to the left or right visual cortical areas depending on where the eyes are pointing. Visual material transferred from the right to left hemisphere for reading may be laterally reversed because the interhemispheric commissures are probably homotopically organised. Therefore accurate positioning of the eyes assumes very great importance when learning to read, in order to ensure that written material is presented consistently to the left hemisphere. Similarly the left hemisphere must be provided with precise information about the position of the eyes if it is to be able to compensate for the mirror imaging effects of commissural transfer from the right hemisphere. We suggest that visual dyslexia is the result of a failure to develop the normal means by which a child achieves this degree of positional control required for reading - eye dominance. The Dunlop test for eye dominance was administered to 80 dyslexics, 50 of whom had been independently classified as ‘visual’ on the basis of their reading errors, and 80 normal readers matched for age and performance IQ. At the time of the tests we were unaware which children were visual or non-visual dyslexics or normal readers. 50 of the visual dyslexics were found to have unfixed dominance on the Dunlop test, whilst no non-visual dyslexic and only 1 normal reader did so. We concluded that unfixed dominance on the Dunlop test indicated unstable eye position control and was therefore a reliable sign of visual dyslexia. We therefore asked 30 visual dyslexics with unfixed dominance on the Dunlop test to wear spectacles with the left lens occluded, in order to encourage the right eye to become dominant. We compared their advance in reading age over 6 months with that of 15 visual dyslexics not so treated, and 30 normal age, sex and performance IQ matched controls. The treated visual dyslexics' reading ages increased at a rate comparable to that of the normal children whereas the untreated children lagged 9 months behind. (P>0.001. Wilcoxon Rank Test) These results also appeared to support our hypothesis that visual dyslexia is a subtle consequence of deficient eye position control.

Hierarchies in the Cerebellum

Clinical Medicine and the Nervous System, 1989

I hope to show that the cerebellum is extremely important in transforming visual information in o... more

An introduction to neurophysiology

Effect of potassium on ventilation in the rhesus monkey

Experimental Physiology, 1992

Increasing the concentration of arterial plasma K+ to 6-8 mM increased ventilation in two sedated... more Increasing the concentration of arterial plasma K+ to 6-8 mM increased ventilation in two sedated analgesic-treated rhesus monkeys who had their end-tidal CO2 held constant during euoxia (arterial oxygen pressure, Pa,O2, ca 100 Torr) and hypoxia (Pa,O2, ca 40 Torr). During euoxia and hypoxia, hyperkalaemia increased ventilation up to 40 and 250%, respectively. This effect was reduced in euoxia and virtually abolished in hypoxia following an abrupt switch to 100% oxygen. Thus the ventilatory response of this primate to hyperkalaemia is at least as sensitive as that of the cat and if hypoxia is added the two stimuli generate a powerful drive to breathing.

Interaction of reflexes from chemo- and pulmonary stretch receptors in control of airway calibre

The Journal of physiology, 1971

The effects of cooling globus pallidus on manual tracking in trained rhesus monkeys [proceedings]

The Journal of physiology, 1979

Electrical activation of visual neurones in nucleus pontis in the cat

The Journal of physiology, 1973

Proceedings: The effect of cooling nucleus interpositus of the cerebellum in rhesus monkeys on the tracking of a visual target

The Journal of physiology, 1975

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