Sonja Prohaska

Summary: Most multi-alignment methods are fully automated, i.e. they are based on a x ed set of m... more Summary: Most multi-alignment methods are fully automated, i.e. they are based on a x ed set of math- ematical rules. For various reasons, such methods may fail to produce biologically meaningful alignments. Herein, we describe a semi-automatic approach to multiple sequence alignment where biological expert knowledge can be used to inuence the alignment procedure. The user can specify parts of

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Genes

In order to describe a cell at molecular level, a notion of a "gene" is neither necessa... more In order to describe a cell at molecular level, a notion of a "gene" is neither necessary nor helpful. It is suf - ficient to consider the molecules (i.e. chromosomes, tran- scripts, proteins) and their interactions to describe cell ular processes. The downside of the resulting high resolution is that it becomes very tedious to address features on the or-

format_quoteIntroduces the concept of the cis-genon and trans-genon as a program governing gene expression, linking genes to regulatory mechanisms.format_quote

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Computational RNomics of Drosophilids - SUPPLEMENT

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