Journal of the Japan Veterinary Medical Association, 2017
A nine-year-old female mixed-br eed dog under went a right caudal lung lobectomy for pulmonar y a... more A nine-year-old female mixed-br eed dog under went a right caudal lung lobectomy for pulmonar y adenocarcinoma, followed by treatment with low-dose cyclophosphamide metronomic chemotherapy. Three months after the resection, metastatic nodules were detected through thoracic radiography for which piroxicam was administered. However, the metastases in the lung continued to progress. Ten months after the resection, the metastatic lesions regressed following the additional administration of toceranib phosphate. Though the dosage and frequency of the administration of toceranib phosphate was adjusted due to sideef fects, such as anorexia, vomiting, and sterile hemorrhagic cystitis, the patient sur vived for months. This case suggests that toceranib phosphate can be ef fective in the treatment of pulmonar y adenocarcinoma. In the future, a combination of cyproheptadine and famotidine could be administered to relieve some of the side ef fects associated with toceranib phosphate, such as anorexia and vomiting, which are considered to be serious problems with its long-term use.
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