Mayo Clinic

A series of Mayo Clinic studies published across Nature journals is advancing the science of healthy aging by deepening researchers' understanding of senescent, or "zombie," cells. The studies: • Introduce new tools to identify senescent cells across tissues. • Reveal mechanisms that drive chronic inflammation associated with aging. • Explore therapeutic strategies to reduce the harmful effects of senescent cells in preclinical models. • Identify a potential blood biomarker that could help assess biological aging in future research. Together, these findings move the field beyond recognizing that senescent cells contribute to aging toward understanding which cells matter most, how they drive disease and how they may be targeted more precisely. The research also supports Mayo Clinic's Precure Research initiative, which aims to predict and intercept biological processes before they develop into disease. Learn more: https://mayocl.in/4fYObr0 | Mayo Clinic Robert and Arlene Kogod Center on Aging

Mayo Clinic’s Cardiovascular Board Review offers the opportunity to learn from practicing specialists who teach, publish, and deliver cardiovascular care every day. Gain practical insights, clarify complex topics, and strengthen your confidence before exam day. Join us and prepare with faculty trusted by physicians worldwide. #MayoClinic #MedicalLearning #CardiologyBoards #CME Meet the Faculty & Register: https://mayocl.in/3SXpKkS

New research identifies a mitochondrial mechanism that may help reduce chronic inflammation during aging. A team of researchers has discovered a previously unknown metabolic-epigenetic pathway that enables senescent cells to produce the inflammatory molecules linked to aging and age-related disease. Building on earlier work showing that mitochondrial DNA and RNA activate immune signaling, the researchers found that mitochondria also generate the metabolic building blocks needed to turn inflammatory genes on through epigenetic regulation. The findings point to an alternative therapeutic strategy. Rather than eliminating senescent cells, researchers are exploring ways to selectively suppress the harmful inflammatory signals these cells produce while preserving their beneficial functions in tissue repair and tumor suppression. This work advances our understanding of the biological mechanisms underlying aging and identifies a promising target for future therapies aimed at improving healthspan. Learn more: https://mayocl.in/4hxXNKA | Mayo Clinic Robert and Arlene Kogod Center on Aging

Is your mental fitness holding you back? On the latest episode of Mayo Clinic On Human Optimization, Dr. Jonathan Jenkins, discusses why training your mind is just as important as training your physical body. Listen to the full episode now: https://bit.ly/4wxBJoa

The future of women's health is becoming more personalized. Areas of progress include AI-assisted breast cancer screening, research into blood-based cancer detection, HPV self-collection for cervical cancer screening and more targeted cancer therapies. At Mayo Clinic, research and innovation are helping shape the future of women's healthcare. Learn more: https://apple.co/4fppPXr

Leukemia isn't a single disease. It's a group of blood cancers, and the exact type plays a major role in how it's treated. Understanding these differences can help patients and families feel more informed and prepared. Learn more: https://mayocl.in/4fFv9oa

A Mayo Clinic-led international phase 3 study found that a new immunotherapy helped many patients with an aggressive form of bladder cancer keep their bladder instead of having it surgically removed. The treatment also kept many patients cancer-free for more than two years and caused mostly mild side effects. The findings were published in The Lancet Oncology. Learn more: https://mayocl.in/4fzp7FB

“A new way to repair joints.” What was covered in the latest episode of Tomorrow's Cure. 1. The realities of repairing damaged cartilage: Cartilage cushions our joints and helps them move smoothly, but unlike many other tissues in the body, it has very little ability to heal itself. When it’s damaged, it can be painful and limiting for patients, making it harder to stay active and maintain their quality of life. 2. How RECLAIM has reshaped what’s possible: RECLAIM combines a patient's own cartilage cells with donor medicinal signaling cells in a single procedure. Together, these cells support cartilage repair in a way that neither could alone. 3. The future of cartilage restoration: Researchers believe RECLAIM has the potential to become a platform technology that unlocks new approaches to repairing other musculoskeletal tissues and help deepen our understanding of how the body heals. To learn more, listen to the full episode “From joint damage to regeneration" now. https://bit.ly/4vDkS1L

One of the most powerful tools in women's health is early detection. Regular cervical cancer screening can find early warning signs before cancer develops. Breast cancer screening can detect disease early — often before any symptoms appear. Knowing your family history, understanding your personal risk, and staying up to date with recommended screenings can make a meaningful difference. Mayo Clinic expert shares why you shouldn't wait for symptoms to start the conversation: https://mayocl.in/4jSRxMK

Whether you're newly diagnosed, living with a NET, caring for a loved one, or simply looking to learn more, Dr. Susanne Warner, liver and pancreas surgeon, and Dr. Thor Halfdanarson, medical oncologist, will answer your questions about diagnosis, treatment options, surgery, clinical trials, symptom management, and what the future of NET care looks like. Join us on July 31 at 3 p.m. CT for a Reddit Ask Me Anything or submit your questions now: https://bit.ly/4gVYKMC | #LetsTalkAboutNETS