Liver Health Breakthroughs in 30 Minutes

We are entering a golden age of liver research. Quin Wills, Founder and CEO of Ochre Bio, made the case on BBC Science Focus's Instant Genius podcast this week - 30 minutes on why the liver might be the most misunderstood organ in the body, and why antifibrotics are the next frontier for patients who currently have nowhere else to turn. The full episode's below. Give it a listen. 👇 #futureofhealthcare

https://lnkd.in/dMKF_TDp Can a simple AST:ALT ratio help detect cirrhosis earlier? A routine liver function test may contain a clue that is easy to overlook: the AST-to-ALT ratio. In this video, we look at evidence from a 14-year study involving nearly 79,000 patients and discuss how the AST:ALT ratio may contribute to identifying patients at risk of cirrhosis—even when the liver enzymes themselves may not appear dramatically abnormal. The key message: Don't just look at AST and ALT individually. Sometimes, the relationship between them matters. If you're a doctor, this is a simple laboratory parameter worth remembering when evaluating patients with suspected chronic liver disease. 🔬 Topic: AST:ALT Ratio & Cirrhosis Detection 🩺 Audience: Doctors & healthcare professionals 📊 Evidence: Large long-term patient cohort Subscribe to Reliver Clinic for evidence-based insights on liver disease, cirrhosis, fatty liver, hepatology and liver health. #Cirrhosis #ASTALT #LiverDisease #Hepatology #LiverFunctionTest #MedicalEducation #CirrhosisDetection #LiverHealth

When Gustavo Caiuby Guimarães and I embarked on writing about his liver transplant journey for The Together Hub, I anticipated two versions of the same story. What I didn't expect was how differently we'd tell it. His pieces are predominantly factual, detailing timelines, appointments, and events. In contrast, mine delve into the emotions: the fear, the exhaustion, the waiting. Before writing the series, I believed he managed the wait better than I did. I thought he was calmer and more patient. However, I was struck by a line in one of his pieces: "I don't think I ever received a call from an unknown number without feeling at least a small spark of hope that it might be someone from the hospital telling me a liver was available and that I needed to come in immediately. Managing that expectation every single day was one of the greatest challenges of the waiting period." He never said that out loud during those months. This revelation shifted my perspective. He wasn't calmer than I was; on the contrary, actually. He just processed it differently. I articulated my feelings through conversation, while he navigated it in silence. Same fear and same wait, just two distinct ways of coping. Collaborating on this series highlighted a truth we often overlook: different doesn't mean wrong. It simply means different. Have you ever had a situation that reminded you that different might not mean wrong, it might just mean... different? For those interested in exploring both perspectives, the full series is available on our Substack (link in the comments).

How the gut and the brain communicate For A Whole New Level, Will Bulsiewicz, MD, discusses the gut-brain axis, the vagus nerve, the gut microbiome, and brain fog. The gut has 500 million nerves, 38 trillion microbes making up the gut microbiome, and 1.3 trillion immune cells. The vagus nerve travels from the gut to the brain, and plays crucial roles in how the gut and brain communicate along the gut-brain axis. The healthy choices we make for our gut can ultimately help with issues such as brain fog. Full episode on the @Levels YouTube channel and all streaming platforms.

Could histamine be contributing to your migraine attacks? The answer is more complicated than a simple yes or no. As a neurologist specializing in migraine and related disorders, I'm fascinated by why some brains appear to be more biologically sensitive to internal and external triggers. I joined Molly O'Brien and the Association of Migraine Disorders to discuss what we know about histamine and migraine, what remains uncertain, and why this topic has generated so much interest in the migraine community.

Plant Compound Icariside II Fights Post-Stroke Depression via Gut-Brain Axis A natural flavonoid activates Sirt6 to reverse depression-like behaviors in stroke mice by reshaping gut microbiota and reducing brain inflammation. https://lnkd.in/gnbgW3QJ #longevity #aging #healthresearc

About E. hystolitica Entamoeba histolytica exists as both a cyst and a trophozoite. The cyst forms are non-motile while the trophozoite form is motile under the microscope. E. histolytica causes amoebic dysentery and amoebic liver abscess. Amoebic dysentery occurs when the trophozoites of the E. histolytica invade the walls of the large intestine and multiply in the submucosa. It ingest red cells from damaged capillaries, reason Red Blood Cells are found in the cytoplasm of the amoebae. The amoebic liver abscess is common in adults than in children. It occurs when the E. histolytica gets to the liver and it later forms liver abscesses.

🎬 Episode 22 of #SpotOnScience is out! 🧠 In this episode, Sergio Castro-Gomez. MD-PhD from the Universitätsklinikum Bonn (University Hospital Bonn) explains his research on the role of the inflammasome adaptor protein ASC in the brain's response to mild traumatic brain injury (mTBI). The research team discovered that ASC drives persistent neuroinflammation for up to 21 days after a mild head injury in a mouse model. Mice lacking ASC showed reduced activation of microglia and astrocytes, produced lower levels of inflammatory molecules such as IL-1β, and experienced fewer memory impairments. In contrast, the spread of ASC aggregates exacerbated brain damage. These findings identify ASC as a key regulator of long-lasting inflammation following mild traumatic brain injury and suggest that targeting ASC could offer a promising strategy to reduce neuroinflammation, improve recovery, and help prevent long-term neurological complications. 🎥 Check out Spot on Science Episode 22: https://lnkd.in/exq6Hyah #SpotOnScience #Research #Neuroscience #Neuroinflammation #TraumaticBrainInjury #Inflammasome #ASC #Immunology

Microscopic asbestos fibers can migrate beyond the lungs, potentially entering lymphatic channels and even the bloodstream. While the precise pathway to the tissue surrounding the testicle isn't fully understood, research suggests lymphatic or circulatory movement may allow fibers to reach distant mesothelial surfaces. These are the same types of cells that line the lungs, abdomen, and heart. When lodged in the tunica vaginalis, the protective membrane of the testicle, these fibers can lead to cellular injury, chronic inflammation, and oxidative stress. #Asbestos #HealthRisks #Mesothelioma #EnvironmentalHealth #PublicHealth

Understanding cystic fibrosis means looking beyond the lungs. With support from Cystic Fibrosis Canada / Fibrose kystique Canada and SHRF, Dr. Veronica Campanucci is investigating how nerves in the gut contribute to digestive symptoms experienced by many people living with cystic fibrosis. Read more: https://lnkd.in/eSRu3Re7