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New consumer health-based guidance values have been set for trifluoroacetic acid! EFSA has just updated (22 July 2026) the consumer health-based guidance values (HBGVs) for trifluoroacetic acid (TFA) by lowering the ADI and setting an ARfD. https://lnkd.in/d7RgAQP3 https://lnkd.in/d2XxQi_w The toxicity of TFA has been an important topic for many years and several authorities such as UBA and RIVM have raised concerns regarding potentially harmful or unacceptable effects of TFA. TFA is formed as a degradation product from various chemicals including several active substances used in plant protection products and due to its toxicity, the exposure to TFA should be considered in the consumer risk assessment. The outcome of the consumer risk assessment is dependent on residues of TFA found in food and drinking water and the level of ADI and ARfD values set to that substance. The previous HBGVs (ADI of 0.05 mg/kg bw/day, no ARfD set) for TFA were set during the peer review of the pesticide risk assessment of the active substance flurtamone (EFSA, 2017). Since then, further assessments have been conducted including a recommendation by ECHA Risk Assessment Committee to classify TFA as Acute Oral Tox. 4 (H302); TFA and TFA Na as Acute InhalationTox. 3 (H331), as Reproductive toxicity 1B for effects on development (H360Df) and as PMT and vPvM. Due to concerns raised by different parties, the European Commission asked EFSA to provide a scientific report, to revise acceptable daily intake (ADI) and acute reference dose (ARfD), for TFA. EFSA launched a targeted call for data from 6 August to 7 October 2024 and established an EFSA Working Group. Based on the weight of evidence, the WG concluded that TFA and TFA Na are unlikely to be genotoxic. The WG established an ADI of 0.014 mg/kg body weight (bw) per day based on the extended one-generation reproductive toxicity study in rats. It represents a decrease of 72% of the acceptable value! In addition, an ARfD of 0.07 mg/kg bw was derived based on the same study. These changes have a high impact on the outcome of the consumer risk assessment from food and drinking water potentially containing TFA. Thus, they can negatively affect the risk assessment outcomes of several TFA forming pesticides that are still approved in the EU such as  Beflubutamid Flonicamid Fluazinam Fluometuron Flutolanil Oxyfluorfen Trifloxystrobin Our team in Staphyt will be happy to guide you and support you in reviewing the consumer risk assessment of your concerned active substances taking into account the changes of the HBGVs for TFA. #Staphyt #PPP #TFA #PFAS #EFSA #ECHA #UBA #RIVM Geoffroy Moulin Romain Galy Michael Hale Jeanne Millan Bernal Elena Campagnoli