Interview with Kelly G. Gwathmey, MD, author of Efficacy and Safety of Gefurulimab in Generalized Myasthenia Gravis: The PREVAIL Phase 3 Randomized Clinical Trial. Hosted by Cynthia E. Armand, MD. https://ja.ma/4bgBaq9
JAMA Neurology
Book and Periodical Publishing
Chicago, Illinois 33,143 followers
A member of the JAMA Network, which includes JAMA, 11 specialty journals, and JAMA Network Open.
About us
JAMA Neurology is an international peer-reviewed journal for physicians caring for people with neurologic disorders and those interested in the structure and function of the normal and diseased nervous system. JAMA Neurology is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications. S. Andrew Josephson, MD, Professor of Neurology and Chair of the Department of Neurology, University of California, San Francisco, is the editor in chief.
- Website
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https://jamanetwork.com/journals/jamaneurology
External link for JAMA Neurology
- Industry
- Book and Periodical Publishing
- Company size
- 1,001-5,000 employees
- Headquarters
- Chicago, Illinois
- Founded
- 1919
- Specialties
- Neurology
Updates
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💬 Editorial by Dixon Yang, MD, MS, Holly Elser, MD, PhD, and Allison Willis, MD, MS: Environmental exposures associated with #ParkinsonDisease include pesticides, hydrocarbon solvents, air pollutants, and residence near farms, industrial sites, or golf courses. National cohort data from Denmark add road traffic noise to this list, suggesting that long-term residential noise exposure may be another place-based risk factor relevant to Parkinson disease. https://ja.ma/3RGOfCp
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Long-term residential road traffic noise was associated with higher risk of #ParkinsonDisease in a nationwide cohort study of Danish adults. Noise measured at both the most and least exposed residential facades was associated with incident Parkinson disease, supporting environmental noise as a potentially relevant place-based exposure. https://ja.ma/4bgB9T7
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💬 Editorial: Among patients with anti–acetylcholine receptor antibody–positive generalized #MyastheniaGravis, gefurulimab, a bispecific nanobody targeting complement factor 5 and human serum albumin, improved activities of daily living and quantitative disease scores vs placebo over 26 weeks. The agent was administered subcutaneously once weekly, and the reported safety profile was consistent with earlier studies of complement inhibition in this population https://ja.ma/44RSbn5
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Gefurulimab is a dual-binding nanobody that blocks complement component 5 and binds albumin to extend half-life, supporting once-weekly self-injection in anti–acetylcholine receptor antibody–positive generalized #MyastheniaGravis. In the phase 3 PREVAIL trial, this complement-targeted approach improved patient-reported and investigator-assessed disease measures and may expand convenient treatment options for long-term disease management. https://ja.ma/4fEIvkO
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💬 Viewpoint: Patients with neurologic illness often face legal and administrative barriers involving housing, public benefits, employment, and the criminal legal system. Medicolegal advocacy by neurologists can affect access to important support for patients 📝 Concise, medically grounded communication can help meet administrative or legal requirements while supporting individual patients and, in some cases, broader policy or legal change. https://ja.ma/4bgBa9D
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Limiting #ParkinsonDisease genetic testing to onset ≤50 years misses most carriers of pathogenic variants, including many eligible for gene-targeted therapies; broader, age-inclusive strategies may improve diagnostic yield. https://ja.ma/4x3RQJM
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Patients with #FunctionalNeurologicalDisorder exhibit frequent psychiatric and neurological comorbidities, worse functional outcomes, higher health care use, and increased mortality compared with multiple sclerosis. https://ja.ma/4vlkjcK
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In a patient with #MMA, new-onset dystonic posturing, blepharospasm, and abnormal gait were associated with structural lesions in the globus pallidus and bilateral defects in dopamine transporter function on PET imaging. https://ja.ma/4yby3JM
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Abdominal clonus was identified in a patient with chronic T5 spinal cord injury, presenting as rhythmic side-to-side umbilical motion on provocation. Clinical and EMG assessment distinguished this phenomenon from other movement disorders, highlighting a novel distribution for clonus in thoracic spinal cord pathology. https://ja.ma/4yfkfOm