Pervin Demir

Ankara Yildirim Beyazit University, Biostatistics and Medical Informatics, Faculty Member

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Dr. Pervin Demir has been serving as an Assistant Professor in the Department of Biostatistics and Medical Informatics at the Faculty of Medicine, Ankara Yıldırım Beyazıt University, since 2023, where she began her career as a Research Assistant in 2012. She completed her primary and secondary education in Ankara and earned her undergraduate degree from the Faculty of Science, Department of Statistics at Ankara University. After completing her undergraduate studies in the Department of Statistics at the Faculty of Science, Ankara University, she obtained her master’s and doctoral degrees from the Department of Biostatistics at the Faculty of Medicine at the same university.
Her academic interests include psychometric analyses, item response theory, clinical research, epidemiology, method development, and multivariate analyses. She has published articles in numerous national and international scientific journals and has provided statistical consultancy for many academic theses, articles, and projects. In addition to her academic work, she teaches Biostatistics at the undergraduate and graduate levels.

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Papers by Pervin Demir

Validity and Reliability of the Turkish Version of the DASH‐TR Questionnaire in Rheumatoid Arthritis Patients, Based on Rasch Analysis

International Journal of Rheumatic Diseases, Jun 6, 2022

AimThis study aimed to examine the validity and reliability of the Turkish version of the Disabil... more AimThis study aimed to examine the validity and reliability of the Turkish version of the Disabilities of the Arm, Shoulder and Hand Problems (DASH‐TR) questionnaire in rheumatoid arthritis (RA) using the Rasch analysis.MethodA total 97 individuals (13 men, 84 women; mean age:51.99 ± 11.12 years, range: 20‐65 years) diagnosed as having RA according to the criteria of the American College of Rheumatology were included. The functional status of the upper extremities was evaluated with the DASH‐TR questionnaire, patient global health with a visual analog scale (VAS), disease activity with Disease Activity Score 28‐C‐reactive protein (DAS28‐CRP), and disability with Health Assessment Questionnaire (HAQ). DASH‐TR was applied to the patients with RA who did not receive any treatment for test‐retest at 1‐week intervals. DASH‐TR results were analyzed using the Rasch analysis.ResultsIn the sample of patients with RA, it was determined that the DASH‐TR scale did not provide a unidimensional structure and the items were collected in two dimensions. The first 20 items and the last nine items were differentiated in the two‐dimensional structure, and the factor load of m21 was low. Person separation index was obtained as 0.948. Internal consistency reliability was quite high. A significant positive correlation was found between the DASH‐TR and VAS, DAS28 and HAQ. There was excellent test‐retest reliability according to the intra‐class correlation coefficient (0.921, 95% CI 0.882‐0.947; P &lt; 0.001).ConclusionThe DASH‐TR is a reliable and valid questionnaire and can be used for measurement of functional status of the upper extremities in RA.

Reliability and Validity of the Turkish Version of the ABILHAND Questionnaire in Rheumatoid Arthritis Individuals, Based on Rasch Analysis

Archives of Rheumatology, Dec 13, 2019

Objectives: This study aims to assess the reliability and validity of the Turkish version of the ... more Objectives: This study aims to assess the reliability and validity of the Turkish version of the ABILHAND questionnaire in individuals with rheumatoid arthritis (RA) [ABILHAND-RA (TR)] using the Rasch analysis. Materials and methods: A total 90 individuals (15 males, 75 females; mean age 51.8±10.9 years; range, 20 to 65 years) diagnosed as RA according to the criteria of the American College of Rheumatology were included. The ABILHAND-RA (TR) was used to determine manual ability, while disease activity was evaluated by the use of Disease Activity Score 28 (DAS28). Jamar hand dynamometer and pinch-meter were used to examine grip and pinch strength of the participants. Nine Hole Peg Test (NHPT) and Duruoz Hand Index (DHI) measured hand disability level. Nottingham Health Profile (NHP) was used to assess quality of life. ABILHAND-RA (TR) results were analyzed using the Rasch analysis method. Results: Item 20 was excluded from the 27-item ABILHAND-RA (TR) as 96% of the individuals rated this item as "easy". The new set of 18 items (7 subtests and 11 items) were found to sustain item invariance and fit to the Rasch model. Significant relationships were found between ABILHAND-RA (TR) and DAS28, bilateral grip strength, NHPT dominant side results, DHI, and NHP. Conclusion: Turkish version of the ABILHAND-RA was found to be clinically valid, reliable, and sensitive enough to be used in clinical evaluations, rehabilitation interventions, and for progression follow-up in individuals with RA.

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The Turkish Validity and Reliability of the Coronavirus-Related Health Literacy Scale on Health Science Students

Konuralp Tip Dergisi, Aug 3, 2023

Objective: Health literacy is one’s ability to access, comprehend, appraise, and apply health-rel... more Objective: Health literacy is one’s ability to access, comprehend, appraise, and apply health-related information. Health literacy has become an important topic since the COVID-19 pandemic. This methodological study aimed to adapt the Coronavirus-Related Health Literacy Scale (HLS-COVID-Q22) to Turkish. Methods: The sample consisted of 539 students of the faculty of health sciences of a university in Turkey. The study was conducted between December 2020 and May 2021. The content validity ratio was calculated for content validity. The construct and concurrent validity, internal consistency reliability, test-retest reliability, and ceiling and floor effects were also determined. A confirmatory factor analysis was performed for construct validity. Results: The fit indices indicated an adequate fit (2/df: 4.970.70) and Cronbach’s alpha values (&gt;0.90) were above acceptable limits. Most students had “adequate health literacy” (71.8%). A quarter of the students had “problematic health literacy” (24.5%). The remaining students had “inadequate health literacy” (3.7%). Students with lower levels of health literacy were more likely to have confusion about coronavirus-related information (p

Comparison of lymph node metastasis rates in breast cancer molecular subtypes; A retrospective clinical study

Medicine Science | International Medical Journal, 2023

Surface Microhardness and Roughness Properties of Biodentine

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, Oct 20, 2020

Aim: Endodontic irrigants may be used during a second-visit treatment or retreatment of root cana... more Aim: Endodontic irrigants may be used during a second-visit treatment or retreatment of root canals with perforations requiring repair biomaterials. After a final flushing with a chemical irrigant, some solution may remain in the root canal space, which can affect the surface of the biomaterial, altering its properties and roughness. The present study aimed to evaluate the effect of various irrigating solutions on surface microhardness and roughness of Biodentine (Septodont, Saint Maur des Fosses, France). Materials and Methods: Fifty Biodentine specimens were prepared and randomly divided into five groups, with 10 samples in each group. The specimens were then stored in different solutions for 5 min: distilled water (control), 5.25% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA) solution, 2% chlorhexidine (CHX), or ozonated water. Surface microhardness (Vickers hardness number [VHN]) and surface roughness were evaluated using 2-D profilometry. The data were analyzed using Kruskal-Wallis and Mann-Whitney U tests. The significance level was set at P < 0.05. Results: The VHN of specimens exposed to NaOCl and CHX was significantly lower than the VHN of specimens exposed to distilled water and EDTA (p < 0.001, p = 0.003, p = 0.001, and p = 0.006, respectively). There was no so significant difference in the mean VHN of the EDTA-treated specimens versus that of the control samples (p = 0.999). Regarding the surface roughness of Biodentine, there were no significant differences between irrigation solutions (2 = 4.243; p = 0.374). Conclusions: Exposure to all the irrigation solutions, except EDTA and ozonated water had an adverse effect on surface microhardness of Biodentine, whereas none of the irrigation solutions significantly changed surface roughness. Therefore, in clinical situations, such as perforation repair with Biodentine, use of EDTA and ozonated water may be preferred.

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Evaluation of unilateral corneal collagen cross-linking on fellow untreated eyes of patients with keratoconus

Arquivos Brasileiros De Oftalmologia, 2022

To evaluate the clinical course and management of infectious interface keratitis after Descemet m... more To evaluate the clinical course and management of infectious interface keratitis after Descemet membrane endothelial keratoplasty. Methods: A total of 352 cases that had undergone Descemet membrane endothelial keratoplasty were retrospectively reviewed. Patients with infectious interface keratitis during follow-up were analyzed. The microbiological analyses, time to infection onset, clinical findings, follow-up duration, treatment, and post-treatment corrected distance visual acuity were recorded. Results: IIK was detected in eight eyes of eight cases. Three fungal and three bacterial pathogens were identified in all cases. All patients received medical treatment according to culture sensitivity. Antifungal treatment was initiated in two cases with no growth on culture, with a preliminary diagnosis of fungal interface keratitis. Intrastromal antifungal injections were performed in all patients with fungal infections. The median time to infection onset was 164 days (range: 2-282 days). The postoperative infectious interface keratitis developed in the early period in two cases. The mean follow-up duration was 13.4 ± 6.2 months (range: 6-26 months). Re-Descemet membrane endothelial keratoplasty was performed in two patients (25%) and therapeutic penetrating keratoplasty in four patients (50%) who did not recover with medical treatment. The final corrected distance visual acuity was 20/40 or better in five patients (62.5%). Conclusions: The diagnosis and treatment of infectious interface keratitis following Descemet membrane endothelial keratoplasty are challenging. Early surgical intervention should be preferred in the absence of response to medical treatment. Better graft survival and visual acuity can be achieved with therapeutic penetrating keratoplasty and re-Descemet membrane endothelial keratoplasty in patients with infectious interface keratitis.

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Evaluation of Radiomorfometric Indexes in Kennedy Class I and Class II Cases

Ado klinik bilimler dergisi, Sep 19, 2022

Amaç: Kennedy sınıf I ve II olgularında panoramik mandibular indeks (Panoramic Mandibular Index;P... more Amaç: Kennedy sınıf I ve II olgularında panoramik mandibular indeks (Panoramic Mandibular Index;PMI), mandibular kortikal indeks (Mandibular Cortical Index;MCI) ve mental indeks (Mental Index;MI) değerlerini bilateral olarak ölçerek dişsizliğin radyomorfometrik indeksler üzerindeki etkisini değerlendirmektir. Gereç ve Yöntem: 64 adet sınıf I, 64 adet sınıf II olmak üzere toplam 128 dijital panoramik radyograf üzerinde PMI, MCI ve MI değerleri bilateral olarak ölçüldü. Bağımsız iki grup karşılaştırması bağımsız iki örnek t testi veya Pearson Ki-kare testi ile yapıldı. Sınıf I' de sağ-sol ve Sınıf II' de dişsiz-dişli taraf karşılaştırmalarında bağımlı iki ölçüm t testi ve McNemar-Bowker testlerinden uygun olan yöntem kullanıldı. Yaş ile MCI arasındaki ilişki Spearman sıra korelasyon katsayısı, PMI ve MI değişkenleriyle ilişki Pearson korelasyon katsayısı ile incelendi. (p<0.05) değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Kennedy sınıf I vakalarında sağ ve sol tarafta MCI skorlaması ile PMI ve MI değerleri arasında fark gözlenmemiştir (p>0.05). Kennedy sınıf II vak'alarında dişli ve dişsiz bölgede MCI dağılımı farklılık göstermiştir (p=0.002). Dişli ve dişsiz taraftan elde edilen PMI ve MI değişken değerlerinin de farklılık gösterdiği tespit edilmiştir (p<0.05). Sınıf I ve II karşılaştırmasında MI değeri sınıf I'de anlamlı derecede yüksek bulunmuştur (p=0.003). Sonuç: MCI, PMI ve MI değerleri diş varlığı veya yokluğu durumuna göre farklılık göstermektedir.

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A Delphi consensus study on the treatment of slipped capital femoral epiphysis: Considerable consensus in mild and moderate slips and limited consensus in severe slips

Journal of Children's Orthopaedics

Purpose: The aim of this expert consensus study was to establish consensus on the treatment of di... more Purpose: The aim of this expert consensus study was to establish consensus on the treatment of different types of slipped capital femoral epiphysis and on the use of prophylactic screw fixation of the contralateral unaffected side. Methods: In this study, a four-round Delphi method was used. Questionnaires including all possible theoretical slip scenarios were sent online to 14 participants, experienced in the field of children’s orthopedics and in the treatment of hip disorders in children. Results: In-situ fixation was considered to be the first treatment choice in all types of mild slip scenarios and in moderate, stable ones. Performing in-situ fixation was not favored in moderate, unstable, and in all severe slip scenarios. In moderate to severe, unstable slip scenarios, there was consensus on the use of gentle closed or open reduction and internal fixation. Any consensus was not established in the optimal treatment of severe, stable slips. There was also consensus on the use of...

Elit Erkek Futbol, Basketbol ve Hentbol Oyuncularının Denge ve Fonksiyonellik Performanslarının Karşılaştırılması: Kesitsel Bir Çalışma

CBÜ Beden Eğitimi ve Spor Bilimleri Dergisi

Bu çalışma, futbol, basketbol ve hentbol branşlarında elit seviyede mücadele eden sporcuların den... more Bu çalışma, futbol, basketbol ve hentbol branşlarında elit seviyede mücadele eden sporcuların denge ve fonksiyonellik bakımından performanslarını karşılaştırmak amacıyla planlanmıştır. Çalışmaya elit seviyede mücadele eden 66 (22 futbol, 22 hentbol ve 22 basketbol) erkek sporcu dahil edilmiştir. Çalışmaya katılan sporcuların dinamik denge performansları Y Denge Testi, statik denge performansları Standing Stork Testi, çeviklik performansı T Çeviklik Testi, esneklik performansları Otur-uzan Esneklik Testi ile değerlendirilirken sıçrama performansı değerlendirmelerinde ise yatay sıçrama için Tek Bacak Sıçrama testi ve dikey sıçrama performansı için VertiMetric cihazı kullanılmıştır. Çalışma sonucunda dikey sıçrama, yatay sıçrama dinamik denge ve statik denge performanslarında dominant ve non-dominant tarafta gruplar arasında anlamlı fark bulunurken (p<0.05) çeviklik ve esneklik performansında branşlar arasında anlamlı fark bulunmamıştır. Aynı zamanda futbol ve hentbol sporcularının ...

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The effect of biacromial and bideltoid distance on shoulder dystocia and birth weight in newborns

Journal of the Turkish-German Gynecological Association

Objective: To evaluate the relationship between neonatal biacromial and bideltoid diameter (BDD),... more Objective: To evaluate the relationship between neonatal biacromial and bideltoid diameter (BDD), birth weight and shoulder dystocia (SD). Material and Methods: This was a prospective observational study conducted on 161 pregnancies who applied to Private Lokman Hekim Hospital for follow-up between February 2021 and August 2021. Maternal height, weight, parity, and presence of SD in the second stage of labor were evaluated in the patients included in the study. The weight, height, head circumference, biacromial and BDD measurements of newborn babies were taken within the first two hours after birth. The primary purpose of the study was to evaluate the relationship between the biacromial and BDD and SD. The secondary purpose of the study was to evaluate the relationship between the biacromial and BDD and macrosomia. Results: The mean age and post-pregnancy body mass index of the participants were 31.3±4.4 years and 29.0±4.0 kg/m 2 , respectively, and 42.9% (n=69) delivered vaginally. The incidence of macrosomia was 6.8% (n=11) in all women and the incidence of SD was 7.2% (n=5) in women who had vaginal deliveries. The mean biacromial diameter (BAD) was 12.4±1.0 cm and the mean BDD was 18.2±1.7 cm. A correlation rate of 0.373 was found between SD and the BAD, and 0.484 between SD and the BDD. The correlation coefficients between macrosomia and the biacromial and BDD were 0.213 and 0.420, respectively. In cases in which the BDD was ≥21 cm, the sensitivity for SD was 100%, the specificity was 90.63%, and the accuracy was 91.30%. The cutoff point for the BAD was ≥14 cm, and the sensitivity and specificity for SD was 63.64% and 89.33%, respectively. The highest correlation for SD was obtained in cases in which there was a history of SD (0.648). Conclusion: The relationship between neonatal biacromial and BDD, and macrosomia and SD were significant. There was no difference between the correlation values of the two measurements in terms of SD. However, the correlation coefficient of the BDD was greater for macrosomia. (

format_quoteA strong correlation of 0.484 between bideltoid diameter and shoulder dystocia (SD) was found, with 100% sensitivity and 90.63% specificity for BDD ≥21 cm.format_quote

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What are the parameters that predict the development of nephrolithiasis and osteoporosis in patients with primary hyperparathyroidism?

Ankara Medical Journal

Objectives: Primary hyperparathyroidism (PHPT) is associated with an increased risk of nephrolith... more Objectives: Primary hyperparathyroidism (PHPT) is associated with an increased risk of nephrolithiasis and osteoporosis, and predicting the development of these diseases will reduce PHP-related morbidities. Materials and Methods: A total of 311 patients with PHPT due to parathyroid adenoma were evaluated retrospectively. The patients were divided into groups, as patients with and without nephrolithiasis and those with and without osteoporosis. Demographic and biochemical variables that could predict the development of nephrolithiasis and osteoporosis in these groups were examined. Results: Nephrolithiasis was observed in 24.44% of 311 PHPT patients. Serum creatinine (Cr), serum calcium (Ca), adjusted Ca (adj Ca), albumin and 24-hour urinary phosphorus (24h uP) levels were higher, and serum Pvalue was significantly lower in patients with nephrolithiasis than those without nephrolithiasis. In the Receiver Operating Characteristic (ROC) analysis, serum Cr ≥0.66 mg/dl, adj Ca ≥10.72 mg/dl, serum P ≤2.71 mg/dl and 24h uP ≥635 mg/day cutoff values were found to have high sensitivity and low specificity values on the risk of developing nephrolithiasis. Of all patients, 43.09% had osteoporosis, and it was determined that only ≥50.50 years (sensitivity 81.34%, specificity 49.51%) and intact parathyroid hormone ≥ 201.50 pg/mL (sensitivity 75.14%, specificity 41.04%) values could predict osteoporosis (Area Under the ROC curve ranged from 0.57 to 0.67). Conclusion: While biochemical parameters are useful in predicting nephrolithiasis in patients with PHPT, the development of osteoporosis seems to be less related to biochemical parameters.

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Sigara bırakma başarısını etkileyen faktörler

Türk Toraks Dergisi, 2013

An investigation of biomechanics, muscle performance, and disability level of craniocervical region of individuals with temporomandibular disorder

Cranio : the journal of craniomandibular practice, 2021

OBJECTIVE To investigate biomechanics, muscle performance, and disability of the craniocervical r... more OBJECTIVE To investigate biomechanics, muscle performance, and disability of the craniocervical region in temporomandibular disorder (TMD) patients and compare them with controls. METHODS Craniocervical posture was evaluated using lateral photography and radiography. Range of motion, muscle performance, disability, and TMD severity were assessed using an inclinometer, Functional Strength Testing of Cervical Spine, Neck Disability Index, and Fonseca Anamnestic Index, respectively. RESULTS Compared to the control group, the TMD group demonstrated higher cervical flexion angle (p=0.005) and neck disability (p<0.001) as well as lower cervical extension (p=0.040), right cervical rotation (p=0.005), left cervical rotation (p<0.001), and tragus-C7-horizontal (p=0.048) angles, and reduced muscle performances (p≤0.001). Most patients had higher than normal craniocervical angle (p<0.001). Muscle performance in each cervical motion (p<0.005) and disability (p<0.001) were associa...

Assessment of paranasal sinus parameters according to ancient skulls’ gender and age by using cone-beam computed tomography

Folia Morphologica, 2019

Background: The aim of this study was to determine whether paranasal sinus dimensions and volume ... more Background: The aim of this study was to determine whether paranasal sinus dimensions and volume can be useful to identify gender and age estimation for ancient skulls using cone-beam computed tomography (CBCT) images. Materials and methods: CBCT scans of 32 ancient skulls of approximately 1000 years of age were included in this retrospective study. The gender and age estimation of the skulls were made by an independent anthropologist, which was considered as the gold standard. Paranasal sinuses' dimensions (width and height) and volumes of each sinus were measured from the CBCT data set that was linked to the three-dimensional rendering software (Anatomage, Invivo 5.2). All measurements were performed by an independent observer. Intra-observer analysis was made. Mann-Whitney and Kruskal-Wallis tests were used to compare paranasal sinus parameters in terms of age estimation and gender (p < 0.05). Results: The results demonstrated no statistically significant difference between measurements (p < 0.05). The measurements were found to be highly reproducible. The mean volumes of frontal and sphenoid sinus were found to be higher in males. The distance from anterior-posterior wall of sphenoid sinus in axial sections is larger in males (p > 0.05). The frontal sinus width and volume increased statistically with age above 60 years of age (p > 0.05). Conclusions: The paranasal volume and dimensions' measurements from CBCT data can be a promising technique to determine gender and age of ancient skulls because of its lower voxel sizes and higher resolution.

format_quoteThe frontal sinus width and volume significantly increase with age above 60, highlighting its potential for age estimation.format_quote

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