C-reactive protein (CRP) is commonly used to guide community-acquired pneumonia (CAP) treatment. ... more C-reactive protein (CRP) is commonly used to guide community-acquired pneumonia (CAP) treatment. A positive association between admission glucose and CRP levels has been observed in patients with CAP. The associations between prediabetes, unknown diabetes, acute-on-chronic hyperglycaemia, and CRP levels, and between admission CRP levels and insulin resistance (IR) in CAP, remain unexplored. This study investigated the associations firstly between chronic, acute, and acute-on-chronic hyperglycaemia and CRP levels, and secondly between admission CRP levels and IR in CAP. In a prospective cohort study of adults with CAP, the associations between chronic, acute, and acute-on-chronic hyperglycaemia (admission glucose minus HbA1c-derived average glucose) and CRP levels until admission day 3 were modelled with repeated-measures linear mixed models. IR was estimated with the homeostasis model assessment of IR (HOMA-IR). The association between admission CRP levels and HOMA-IR was modelled with linear regression. In 540 patients, no association between chronic, acute, or acute-on-chronic hyperglycaemia and CRP levels was found. In 266 patients, every 50 mg/L increase in admission CRP was associated with a 7% (95% CI 1-14%) higher HOMA-IR. In conclusion, our findings imply that hyperglycaemia does not influence CRP levels in patients with CAP, although admission CRP levels were positively associated with IR.
Comparison of Treatment with Insulin Degludec and Glargine U100 in Patients with Type 1 Diabetes Prone to Nocturnal Severe Hypoglycaemia (HypoDeg): A Prospective, Randomized, Open-Label, Crossover Trial
C-reactive protein (CRP) is commonly used to guide community-acquired pneumonia (CAP) treatment. ... more C-reactive protein (CRP) is commonly used to guide community-acquired pneumonia (CAP) treatment. A positive association between admission glucose and CRP levels has been observed in patients with CAP. The associations between prediabetes, unknown diabetes, acute-on-chronic hyperglycaemia, and CRP levels, and between admission CRP levels and insulin resistance (IR) in CAP, remain unexplored. This study investigated the associations firstly between chronic, acute, and acute-on-chronic hyperglycaemia and CRP levels, and secondly between admission CRP levels and IR in CAP. In a prospective cohort study of adults with CAP, the associations between chronic, acute, and acute-on-chronic hyperglycaemia (admission glucose minus HbA1c-derived average glucose) and CRP levels until admission day 3 were modelled with repeated-measures linear mixed models. IR was estimated with the homeostasis model assessment of IR (HOMA-IR). The association between admission CRP levels and HOMA-IR was modelled with linear regression. In 540 patients, no association between chronic, acute, or acute-on-chronic hyperglycaemia and CRP levels was found. In 266 patients, every 50 mg/L increase in admission CRP was associated with a 7% (95% CI 1-14%) higher HOMA-IR. In conclusion, our findings imply that hyperglycaemia does not influence CRP levels in patients with CAP, although admission CRP levels were positively associated with IR.
Comparison of Treatment with Insulin Degludec and Glargine U100 in Patients with Type 1 Diabetes Prone to Nocturnal Severe Hypoglycaemia (HypoDeg): A Prospective, Randomized, Open-Label, Crossover Trial
Social Science Research Network, 2020
Author response for "Comparison of treatment with insulin degludec and glargine U100 in patients with type 1 diabetes prone to nocturnal severe hypoglycaemia: The HypoDeg randomised, controlled, open‐label, cross‐over trial
Menneskebilleder i politisk ekspertrådgivning - Dagpengekommissionen
Author response for "Comparison of treatment with insulin degludec and glargine U100 in patients with type 1 diabetes prone to nocturnal severe hypoglycaemia: The HypoDeg randomised, controlled, open‐label, cross‐over trial
Development and preclinical evaluation of intrinsically radiolabeled [Pd-103] AuPd nanoparticles in an injectable seed-forming system for nanobrachytherapy
Intensive outpatient treatment for PTSD: an open trial combining prolonged exposure therapy, EMDR, and physical activity
European Journal of Psychotraumatology, Oct 7, 2022
Stillbirth and early neonatal mortality rates may be underestimated using recall information: A comparison of demographic surveillance methodologies
Tropical Medicine & International Health, Jun 2, 2023
Quantum chemical modeling of organic enhanced atmospheric nucleation: A critical review
Wiley Interdisciplinary Reviews: Computational Molecular Science, May 9, 2023
Aerosol particles are important for our global climate, but the mechanisms and especially the rel... more Aerosol particles are important for our global climate, but the mechanisms and especially the relative importance of various vapors for new particles formation (NPF) remain uncertain. Quantum chemical (QC) studies on organic enhanced nucleation has for the past couple of decades attracted immense attention, but very little remains known about the exact organic compounds that potentially are important for NPF. Here we comprehensively review the QC literature on atmospheric cluster formation involving organic compounds. We outline the potential cluster systems that should be further investigated. Cluster formation involving complex multi‐functional organic accretion products warrant further investigations, but such systems are out of reach with currently applied methodologies. We suggest a “cluster of functional groups” approach to address this issue, which will allow for the identification of the potential structure of organic compounds that are involved in atmospheric NPF.This article is categorized under: Theoretical and Physical Chemistry > Reaction Dynamics and Kinetics Software > Quantum Chemistry Theoretical and Physical Chemistry > Thermochemistry Molecular and Statistical Mechanics > Molecular Interactions
Many popular sports involve matches between two teams or players where each team have the possibi... more Many popular sports involve matches between two teams or players where each team have the possibility of scoring points throughout the match. While the overall match winner and result is interesting, it conveys little information about the underlying scoring trends throughout the match. Modeling approaches that accommodate a finer granularity of the score difference throughout the match is needed to evaluate in-game strategies, discuss scoring streaks, teams strengths, and other aspects of the game. We propose a latent Gaussian process to model the score difference between two teams and introduce the Trend Direction Index as an easily interpretable probabilistic measure of the current trend in the match as well as a measure of post-game trend evaluation. In addition we propose the Excitement Trend Index -the expected number of monotonicity changes in the running score difference -as a measure of overall game excitement. Our proposed methodology is applied to all 1143 matches from the 2019-2020 National Basketball Association (NBA) season. We show how the trends can be interpreted in individual games and how the excitement score can be used to cluster teams according to how exciting they are to watch.
combined. Results: Using pneumococcal vaccine only enables to achieve the targeted 15% reduction ... more combined. Results: Using pneumococcal vaccine only enables to achieve the targeted 15% reduction in cases, hospital occupancy or deaths at annual coverage of respectively 76.9%, 81.0%, 57.1%, and at the lowest annual vaccination budget of respectively € 26, € 27 and € 19 million. If meningococcal type B vaccine were prioritized in a UMV program, pneumococcal vaccine should still be added to achieve the public health objective. In such scenario, the annual vaccination budget would amount to € 57, € 59 and € 48 million, at the maximum achievable coverage of 60% for meningococcal vaccine and pneumococcal coverage of 76.8%, 80.8% and 47.9%. ConClusions: Pneumococcal vaccine on its own can achieve the targeted 15% reduction in disease burden at the lowest vaccination budget. Vaccination against pneumococcal disease should therefore be prioritized in a UMV program in Poland.
When Government drawings, specifications, or other data are used for any purpose other than in co... more When Government drawings, specifications, or other data are used for any purpose other than in coninection with a definitely related Government procurement operation, the United States Government thereby incurs no responsibility nor any obligation whatsoever; and the fact that the Government may have formulated, furnished, or in any way supplied the said drawings, specificationsi or other data, is not to be regarded by implication or otherwise as in any manner licensing the holder or any other person or corporation, or conveying any rights or permission to manufacture, use, or sell any patented invention that may in any way be related thereto.
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Papers by Andreas Jensen