The challenge of modelling cancer presents a major opportunity to improve our ability to reduce m... more The challenge of modelling cancer presents a major opportunity to improve our ability to reduce mortality from malignant neoplasms, improve treatments and meet the demands associated with the individualization of care needs. This is the central motivation behind the ContraCancrum project. By developing integrated multi-scale cancer models, ContraCancrum is expected to contribute to the advancement of in silico oncology through the optimization of cancer treatment in the patient-individualized context by simulating the response to various therapeutic regimens. The aim of the present paper is to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by bringing together basic science and information technology modules. In addition, the integration of the multi-scale tumour modelling components has led to novel concepts of personalized clinical decision support in the context of predictive oncology, as is also discussed in the paper. Since clinical adapt...
Background: Human bocavirus (HBoV) is a newly discovered parvovirus and increasing evidences are ... more Background: Human bocavirus (HBoV) is a newly discovered parvovirus and increasing evidences are available to support its role as an etiologic agent in lower respiratory tract infection (LRTI). The objective of this study is to assess the impact of HBoV viral load on clinical characteristics in children who were HBoV positive and suffered severe LRTI. Methods: Lower respiratory tract aspirates from 186 hospitalized children with severe LRTI were obtained by bronchoscopy. HBoVs were detected by real-time PCR and other 10 infectious agents were examined using PCR and/or direct fluorescent assay. Results: Thirty-one patients (24.6%) were tested positive for HBoV in the respiratory tract aspirates. Fifteen samples had a high viral load (.10 4 copies/mL) and the other sixteen samples had a low viral load (,10 4 copies/mL). The duration of presented wheezing and hospitalization was longer in children with high viral load of HBoV than that in children with low viral load. The days of wheezing showed a correlation with viral load of HBoV. We confirmed that HBoV was frequently detected in patients with severe LRTI. Wheezing was one of the most common symptoms presented by patients with positive HBoV. A high HBoV viral load could be an etiologic agent for LRTI, which led to more severe lower respiratory tract symptom, longer duration of wheezing and hospitalization.
Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract ... more Respiratory syncytial virus (RSV) is the most important cause of severe, lower respiratory tract infections in infants, and RSV infections have been associated with chronic wheezing and asthma during childhood. However, the mechanism of RSV-induced airway inflammation and airway hyperresponsiveness (AHR) is poorly understood. Furthermore, there are presently neither effective vaccines nor drugs available for the prevention or treatment of RSV infections. In this study, we investigated the effect of the plant extract resveratrol as a means of preventing airway inflammation and attenuating RSV-induced AHR. Our data showed that resveratrol reduced RSV lung titers and the number of infiltrating lymphocytes present in bronchoalveolar lavage fluid (BALF) and reduced inflammation. Furthermore, resveratrol attenuated airway responses to methacholine following RSV infection and significantly decreased gamma interferon (IFN-γ) levels in BALF of RSV-infected mice. Data presented in this report...
EGFR Mutations Associated With Superior Intracranial Response and Progression-free Survival After Brain Irradiation in Non-small Cell Lung Cancer With Brain Metastasis
International Journal of Radiation Oncology*Biology*Physics, 2011
Purpose/Objective(s): The purpose of this study was to identify the predictive factors of skeleta... more Purpose/Objective(s): The purpose of this study was to identify the predictive factors of skeletal-related events (SREs) in NSCLC patients with bone metastases. Materials/Methods: Time-to-the first SRE and SRE-free survival and their associations with the patient characteristics were evaluated retrospectively in 416 patients in NSCLC with bone metastatic. Univariate and multivariate statistical methods were used to determine significant risk factors for SRE-free survival. Results: The overall median survival time was 11.5 (9.9-13.2) months from bone metastases. The median observation period for SREs was 8.9 (7.9-9.9) months. Out of 416 patients with bone metastases, 159 (38.2%) developed at least one SRE during or after the initial treatment. On univariate analysis, patients with characteristics such as male, nonadenocarcinoma, ever-smoking, bone metastases with soft-tissue extension and no history of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) therapy had a shorter median time from bone metastasis to first SRE. The results of multivariate analysis revealed that male, bone metastases with soft-tissue extension, no history of EGFR-TKI therapy risk factors for the first SRE, with hazard ratios (HRs) (95% confidence interval [CI]) 1.414 (1.050-1.905), 1.225 (1.030-1.457), 1.731 (1.327-2.259), respectively. Conclusions: The presence of bone metastases with soft-tissue extension was significantly associated with the development of SREs in patients with advanced NSCLC. Male sex and no history of EGFR-TKI therapy were also independent risk factor of development of SREs throughout the course of disease.
Study and design of active knowledge aided system objecting to rapid CAE
Recently,many knowledge aided system and software have appeared,they can offer the usage of softw... more Recently,many knowledge aided system and software have appeared,they can offer the usage of software to users,but they have not the knowledge support of field mechanism,and they can not offer the intelligent support by judging man’s knowledge lacking activly.The article elaborates the necessity of establishing an active knowledge aided system through analyzing the situation of enterprises in china at present,and we take the FEA analysis of automotive ball as an example,design the whole structure of system.Finally,the article elaborates the implement mechanism from the point of view of functions,now we have obtained the good results.
A proper total k-coloring of a graph G is a star total k-coloring if the colorings of vertices an... more A proper total k-coloring of a graph G is a star total k-coloring if the colorings of vertices and edges of any path of length 3 in G are all different. The least number of k spanning over all star total k-colorings of G, denoted by χ st (G), is called the star total chromatic number of G. In this paper, we obtained the star total chromatic numbers of Mycielski of path and cycle graphs.
Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China; Labeling neural stem cells with superparamagnetic iron oxide in vitro and tracking after implantation with MM in vivo [J]
Liquids, metastable liquids, and glasses; glassy soft matters; materials far from equilibrium and... more Liquids, metastable liquids, and glasses; glassy soft matters; materials far from equilibrium and under extreme environments; atomistic modeling and simulation; neutron and X-ray scattering. More than 30 publications (Citations >700, h-index 14) in book sections, high-impact journals such as P.
Uploads
Papers by Enqi Liu