Anti-myelin-associated glycoprotein (MAG) neuropathy is a rare, immune-mediated demyelinating con... more Anti-myelin-associated glycoprotein (MAG) neuropathy is a rare, immune-mediated demyelinating condition. It is characterised by an association with an IgM monoclonal gammopathy and the presence of pathogenic anti-MAG antibodies. Research into this field began in the 1980s. Initial therapeutic approaches aimed to reduce the M protein concentration using treatments such as plasma exchange, steroids, chlorambucil, azathioprine and cyclophosphamide. Some patients experienced partial benefit, indicating that mechanisms beyond damage solely caused by elevated M protein are involved. Consequently, immune-directed therapies, such as IVIg and rituximab, have demonstrated some efficacy in this patient group. Some case reports suggested the use of Lenalidomide as a potential therapeutic option. This is the first case report showing the successful use of pomalidomide in anti-MAG neuropathy.
Artificial intelligence (AI) has emerged as a transformative force in healthcare, bridging gaps i... more Artificial intelligence (AI) has emerged as a transformative force in healthcare, bridging gaps in knowledge and accessibility. Among the most talked-about advancements is ChatGPT, an AI chatbot developed by OpenAI. Launched in 2022, ChatGPT uses advanced language processing to engage users in conversational exchanges on a variety of topics, including health. Its ability to explain complex concepts in simple, easy-to-understand language has captured attention worldwide. However, while it has the potential to educate and empower patients, questions about its accuracy and reliability remain.
Background: This meta-analysis investigates the effects of different types and doses of exercise ... more Background: This meta-analysis investigates the effects of different types and doses of exercise interventions on depressive symptoms among college students, aiming to provide scientific evidence for exercise prescription. Methods: A total of 22 empirical studies were included through searching databases such as Web of Science, PubMed, Cochrane Library, Google Scholar and CNKI. Result: Results showed that flexibility training had the most significant effect on alleviating depressive symptoms (g = 1.09, P < 0.01), followed by traditional Chinese health exercises (g = 0.80, P < 0.01), anaerobic exercise (g = 0.78, P < 0.01) and aerobic exercise (g = 0.70, P < 0.01). Subgroup analysis indicated that the most effective intervention consisted of low-intensity exercise (g = 0.95), performed 3-4 sessions per week (g = 0.79), ≥90 minutes per session (g = 0.77), lasting for 4-8 weeks (g = 0.90). Metaregression revealed that exercise intensity and intervention duration were negatively associated with effect size, while session length and frequency were positively associated. Conclusion: These findings suggest that exercise interventions are effective in alleviating depressive symptoms among college students, with flexibility training of low intensity and high frequency demonstrating the greatest efficacy.
Biochemical indicators are critical for the early detection, evaluation and prognosis of cardiova... more Biochemical indicators are critical for the early detection, evaluation and prognosis of cardiovascular disorders (CVD). The clinical uses and functions of both established and developing indicators were examined. Additionally, B-type natriuretic peptide (BNP) and troponins are recognized biomarkers used to diagnose heart failure and myocardial infarction. Emerging biomarkers that are considered as promise markers for CVD disease in pathways and risk stratification interpretation include high sensitivity troponins, galectin-3 and microRNAs. Although these markers are helpful for CVD, there are many problems including assay uniformity, interindividual variability and specificity. The use of sensitive assays and customized medicine techniques and the use of biomarker for a more thorough risk assessment are the main future prospects. New and conventional markers are included into recent clinical standards to improve patient care. This oversite of the potential of biochemical markers to change cardiovascular outcomes further exemplifies the revolutionary possibility of such markers in healthcare.
Preterm infants undergo a highly critical and stressful intensive care process in neonatal intens... more Preterm infants undergo a highly critical and stressful intensive care process in neonatal intensive care units (NICUs) to sustain life. During this period, they are exposed daily to numerous repeated painful invasive procedures and the associated stress. However, current knowledge regarding the long-term consequences of early-life pain and stress exposure in preterm infants remains limited, underscoring the need for further investigation. Histopathological evaluation in young adulthood revealed significantly higher numbers of apoptotic cells in the hippocampal CA1 region, dentate gyrus, parietal cortex, prefrontal cortex and retrosplenial cortex in the intervention group compared to controls (p < 0.001). In conclusion, the findings of this study indicate that pain-induced stress resulting from repeated invasive procedures in preterm neonatal rats adversely affects physical growth, motor development, behavioral outcomes and learning performance.
Background: A rudimentary uterine horn is a rare congenital anomaly that results from the abnorma... more Background: A rudimentary uterine horn is a rare congenital anomaly that results from the abnormal development of one Müllerian duct, while the other duct remains underdeveloped. This condition is often associated with a unicornuate uterus and may lead to severe complications, such as endometriosis, due to retrograde menstruation. The diagnosis of this anomaly is challenging due to non-specific symptoms and high misdiagnosis rates. Case summary: We present the case of a 45-year-old woman who experienced progressive dysmenorrhea for 10 years and prolonged menstrual periods for 3 months. Imaging studies, including ultrasound and MRI, suggested a double uterus with multiple fibroids and potential hydrosalpinx. During laparoscopic surgery, the patient was found to have a rudimentary uterine horn with a small connection to the unicornuate uterus, right ovarian cysts, severe pelvic adhesions, and endometriosis. The surgical procedures included the removal of the rudimentary horn, right ovarian cystectomy, and excision of fibroids from both the left and right uteri. Postoperative pathology confirmed leiomyoma and adenomyosis. The patient is currently under follow-up with normal ultrasound and laboratory findings. Conclusion: This case highlights the importance of early recognition and accurate diagnosis of rudimentary uterine horn, which is often misdiagnosed due to atypical presentations. A combination of imaging techniques, clinical evaluation, and surgical exploration is critical for proper management. Early intervention can help alleviate symptoms, prevent complications like endometriosis, and improve patients' quality of life.
Introduction: This study investigated sociodemographic and behavioural predictors of mobility sta... more Introduction: This study investigated sociodemographic and behavioural predictors of mobility status among older adults in southeastern Nigeria, where evidence on fall risk and mobility outcomes remains limited. Methods: A facility-based cross-sectional survey was conducted from August 2025 to January 2026 across 20 healthcare facilities selected through multistage sampling from five states in the Southeast geopolitical zone. A total of 303 older adults (≥60 years; mean age 71.5 years) were recruited through simple random sampling technique. Data were collected using a structured, prevalidated questionnaire (Cronbach's α = 0.84) assessing socio-demographics, mobility status, fall history, knowledge, attitudes and preventive practices. Chi-square tests and multivariate logistic regression were applied, with statistical significance set at p < 0.05. Results: Among participants, 58.7% reported mild mobility difficulty and 41.3% reported severe difficulty. Mobility status was significantly associated with sex (p = 0.022), religious affiliation (p < 0.001) and marital status (p < 0.001), but not with age, education level or living arrangement. Multivariate analysis identified male sex (OR = 1.73; 95% CI: 1.10-2.72), Christian affiliation (OR = 3.78; 95% CI: 2.30-6.20) and being married (OR = 4.38; 95% CI: 2.60-7.36) as predictors of mild mobility difficulty. Fallrelated attitudes (p < 0.001), knowledge of fall risks (p = 0.016) and preventive practices (p = 0.040) were significantly associated with mobility status. Conclusion: With a 94.7% response rate and 80% statistical power, findings underscore the influence of sociodemographic and behavioral factors on mobility among older Nigerians, supporting culturally tailored fall-prevention interventions.
Objective: Based on the two-sample Mendelian randomization method, this study explores the causal... more Objective: Based on the two-sample Mendelian randomization method, this study explores the causal relationship between Alzheimer 's family history and cervical malignant tumors. Methods: We extracted data from the IEU Open GWAS database and Finnish R9 database from the Alzheimer family history, cervical malignant tumors (such as cervical squamous cell carcinoma, cervical adenocarcinoma and other cervical malignant tumors). By setting the correlation strength and eliminating the linkage disequilibrium, the instrumental variables are screened out. Inverse variance weighting (IVW) was used as the main analysis method, supplemented by weighted median, MR-Egger and weighted pattern as supplementary analysis methods to evaluate causal effects. In addition, the Cochran Q test of IVW and MR-Egger was used for heterogeneity analysis and the MR-Egger intercept and MR-PRESSO analysis method were used for pleiotropic test. At the same time, the stability of the results was evaluated using the leave-one-out method. Finally, meta-analysis was used to further clarify the causal relationship between the two. Results: The results of MR analysis between father's disease history and cervical adenocarcinoma suggested that father 's Alzheimer 's disease increased the risk of cervical adenocarcinoma (OR=1.99; 95 % CI:1.04-3.80, P =0.037) and no association was found in the MR analysis between the other two samples. Heterogeneity test suggested that there was no heterogeneity in the study. The results of the leave-one-out method and the multi-effect test showed stability. Conclusion: The study confirmed that the father with Alzheimer 's disease will increase the risk of cervical adenocarcinoma, but has no significant effect on cervical squamous cell carcinoma. In addition, the mother with Alzheimer 's disease or other family history of Alzheimer 's disease has no significant effect on the occurrence of cervical malignant tumors. In the future clinical work, we should appropriately strengthen the monitoring and follow-up of women with Alzheimer 's disease in their fathers to prevent or detect cervical malignant lesions early.
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