Classical enzymes usually consist of enzyme domains and non-enzyme domains. The functional domain... more Classical enzymes usually consist of enzyme domains and non-enzyme domains. The functional domain of an enzyme is the region with a specific spatial structure where the enzyme performs its catalytic function. Specifically, the enzyme active site contains a binding region and a catalytic region, which participate in the binding of substrates and catalyze specific chemical reactions of substrates, respectively. The non-enzyme functional region regulates substrate protein activity mainly through protein-protein interaction (PPI), which is independent of catalytic function and mediates the interaction between substrate and different protein components in signaling pathways, such as allosteric regulation and scaffold protein function.
Targeted protein degradation (TPD) is a technology that induces protein degradation of human dise... more Targeted protein degradation (TPD) is a technology that induces protein degradation of human disease targets by using cellular proteasome and lysosome pathways. One of its main application scenarios is the development of drugs targeting previously undruggable targets. Current advances in TPD technology have focused on tumor targets, and researchers are trying to extend the technology to other therapeutic areas.
Yeast is a single-celled and versatile microorganism that is widely used in various industries, s... more Yeast is a single-celled and versatile microorganism that is widely used in various industries, such as brewing, food, and biotechnology. However, not all yeast strains possess the desired characteristics required for optimal production. Therefore, methods of yeast strain improvement have been developed to enhance the desirable traits of yeast strains and to benefit industries involving yeast. Yeast strains with desirable properties are crucial for these industries to achieve optimal productivity and quality.
Engineered bacteria can be used as anticancer agents, in which suitable bacterial strains are eng... more Engineered bacteria can be used as anticancer agents, in which suitable bacterial strains are engineered to colonize hypoxic tumor environments and provide therapeutic payloads. Tumor hypoxia is a common feature of most solid tumors and is considered to be a state of reduced tissue oxygen levels compared to healthy tissue. For example, the partial pressure of oxygen (pO2) in the renal cortex is 37.6mmHg, whereas the pO2 in the corresponding renal cell carcinoma is only 9.6mmHg.
With the rapid development of the pharmaceutical industry, green pharmaceuticals represented by f... more With the rapid development of the pharmaceutical industry, green pharmaceuticals represented by fermentation production, asymmetric catalysis, and continuous flow are increasingly sought after. Fermentation of enzymes and active pharmaceutical ingredients (APIs) is one of the important ways of the API production process, which mainly covers amino acids and antibiotics, and some biological products. These compounds are usually obtained by a semisynthetic method combining fermentation and chemical synthesis.
Uploads
Papers by Marina Barrow
Drafts by Marina Barrow