Effect of a dietary supplement on the reduction of lymphedema-progression in mouse tail-cut model
PubMed, Dec 1, 2021
Objective: The aim of our study was to evaluate in vivo, in a mouse tail model of lymphedema, the... more Objective: The aim of our study was to evaluate in vivo, in a mouse tail model of lymphedema, the effects of a dietary supplement, Garlive®, based on hydroxytyrosol from olive leaves, spermidine from rice seeds, hesperidin from citrus fruits and vitamin A. Hydroxytyrosol has anti-inflammatory, antioxidant and antimicrobial activities and inhibits leukotriene B4 generation; spermidine is able to inhibit the production of pro-inflammatory cytokines and mediators; hesperidin inhibits the secretion of pro-inflammatory cytokines: IFN-γ, IL-2, IL-4, IL-10; vitamin A deficiency was shown to induce inflammation and aggravate existing inflammatory states, whereas supplementation with vitamin A could ameliorate inflammation. Materials and methods: The active compounds were included in tablets: 250 mg of olive leaf extract titrated in 10% hydroxytyrosol, 200 mg of citrus fruits extract titrated in 60% hesperidin, 10 mg of rice (Oryza sativa) seeds extract titrated in 1% spermidine and 0.8 mg of vitamin A. Mice of an inbred group were randomly selected and divided in the control group and drug-treated group. The wound necessary for lymphedema generation was made on the tail of each mice 1 cm below the base of the trunk. Results: After surgical intervention, there was a gradual increase in the circumference of both ends of the wound. The control group showed higher increase of tail volume than the drug-treated group. The differences in tail swelling between the control group and the drug-treated group were significantly different. The peak of swelling was anticipated to the 6th day in the drug-treated group, whereas in the control group the peak was reached later on. Conclusions: The tested drug prevented the induction of swelling from day 5th of wound creation and decreased the duration of swelling, favoring the wound healing.
Effect of ethanolic extract of Cyperus rotundus reduces the surgical induced secondary lymphedema and oxidative stress in adult mice tail
BackgroundLymphedema is clinically manifested as swelling in the extremities due to abnormal accu... more BackgroundLymphedema is clinically manifested as swelling in the extremities due to abnormal accumulation of protein rich in the extravascular interstitial space resulting in irreversible structural changes to the limb (s). The aim of this explorative work was to evaluate the effect ofCyperus rotundusroot (CRR) ethanolic extract in a mouse tail model of secondary lymphedema. Method: Mice were temporally anaesthetised under sterile condition and the skin from the tail was removed from distal part of the trunk after leaving 1cm of distance. The animals were divided into Experimental control (EC) andCyperus rotundusroot (CRR) 80 mg/kg b.w. /day) treated groups. Change in tail volume and circumference were monitored for 20 days. TNFα, SOD and catalase were estimated from blood obtained through retro-orbital at day 0, 5, 10 and 15. Further TS of upper part of the tail skin was stained with H&E stain to document histological changes mRNA level of COX-2 was estimated from the skin.RESULTSE...
International Journal of Science and Healthcare Research
Background: Musculoskeletal disorders are a widespread and increasing occupational health problem... more Background: Musculoskeletal disorders are a widespread and increasing occupational health problems worldwide. The disorders that result from work related event are known as “work related musculoskeletal disorders” where workers experience discomfort in one or multiple body parts, pain in joints, tingling and swelling. MSDs are reported to significantly impact on quality of life, cause lost work time, increase work restriction, or disability. The police have high possibility of showing musculoskeletal pains due to rough physical activities, including duties, traffic control, driving, security, sports and drills, and handling heavy equipment, and are highly hospitalized or treated. Aim and Objectives: To determine the prevalence and risk factors of Musculoskeletal disorders in Police Employees. Methodology: The study was conducted among 100 police employees. The data was collected using Self - Administered Questionnaire, Nordic Musculoskeletal Questionnaire and Operational Police Stre...
International Journal for Research in Applied Science and Engineering Technology
The significance of rainfall as a crucial natural resource for various crop cultivations cannot b... more The significance of rainfall as a crucial natural resource for various crop cultivations cannot be overstated; however, its excessive occurrence or manifestation in unfavourable climatic conditions can prove fatal by causing crop decay. The principal aim of this research endeavour is to safeguard crops against such aberrant weather circumstances. The proposed solution addresses a major predicament in the realm of agriculture, offering protection against unwanted precipitation or extreme heat through the implementation of an umbrella-like structure. This model encompasses the designated area, employing a mechanism comprising nuts, bolts, motors, gears, and sensors to facilitate the opening and closing of the umbrella in response to rain and temperature variations. The automated functionality of this system holds the potential to deliver optimal crop protection. I.
Acute lung injury (ALI) is a lethal respiratory disorder; directed uncontrolled inflammation, slo... more Acute lung injury (ALI) is a lethal respiratory disorder; directed uncontrolled inflammation, sloughing of the alveolar cells and their diffusion, and altered cardiorespiratory parameters with a global mortality rate of 40%. This study was designed to assess the preventive effect of a polyherbal decoction (Bronco T, 1.5 g/kg b. w.) on cardiorespiratory variables in oleic acid-induced ALI in rats. Oleic acid increases the level of neutrophil infiltration leading to pulmonary edema and alters the cardiorespiratory dynamics. The adult male rats were surgically cannulated and treated with intravenous oleic acid (0.38 ml/kg b. w.) to establish the ALI model. Bronco T was pre-administered orally 3 hours before oleic acid. The biophysical, histological, biochemical, and molecular effects were compared with dexamethasone (5 mg/kg b. w. i. p.). The animals were randomly divided into control, lethal, standard, and treatment groups. Respiratory frequency (RF), heart rate (HR), and mean arteria...
Nanotherapeutic treatment of the invasive glioblastoma tumor microenvironment
Advanced Drug Delivery Reviews
Characteristics of vibration at failure and its relation to rock properties during tensile failure
International Conference on Multimedia Information Networking and Security, Apr 18, 2021
UNET Lung Segmentation Weights for Chest X Rays
Role of Ayurvedic Plants as Anticancer Agents
Methods in Molecular Biology, 2022
The use of natural products has been increasing at a rapid pace, worldwide, with the aim to maint... more The use of natural products has been increasing at a rapid pace, worldwide, with the aim to maintain a healthy lifestyle and to modify one's dietary habits. Ayurveda is a domain that has numerous wealth of information concerning medicinal plants and its part in controlling numerous ailments, such as neoplastic, cardiovascular, neurological plus immunological ailments. The use of such medicinal plants is important for preventing such diseases, especially "cancer" which is the succeeding foremost cause of mortality collectively. Even though abundant developments have been made in the management and control of cancer progression, substantial deficits and scope for advancement still continue to be unchanged. Several lethal adjacent consequences occur throughout the course of chemotherapy. Natural treatments, such as the use of plant-derived products in the treatment of cancer, might reduce the hostile side effects. Presently, a few plant-based products and its phytoconstituents are being utilized for the management of cancer. Here we have focused on numerous plant-derived phytochemicals and promising compounds from these plants to act as anticancer agents, along with their mechanisms of action.
Bioadhesives are intended to facilitate the fast and efficient reconnection of tissues to restore... more Bioadhesives are intended to facilitate the fast and efficient reconnection of tissues to restore their functionality after surgery or injury. The use of mussel-inspired hydrogel systems containing pendant catechol moieties is promising for tissue attachment under wet conditions. However, the adhesion strength is not yet ideal. One way to overcome these limitations is to add polymeric nanoparticles to create nanocomposites with improved adhesion characteristics. To further enhance adhesiveness, polydopamine nanoparticles with controlled size prepared using an optimized process, were combined with a mussel-inspired hyaluronic acid (HA) hydrogel to form a nanocomposite. The effects of sizes and concentrations of polydopamine nanoparticles on the adhesive profiles of mussel-inspired HA hydrogels were investigated. Results show that the inclusion of polydopamine nanoparticles in nanocomposites increased adhesion strength, as compared to the addition of poly (lactic-co-glycolic acid) (PLGA), and PLGA-(N-hydroxysuccinimide) (PLGA-NHS) nanoparticles. A nanocomposite with demonstrated *
International Journal for Research in Applied Science and Engineering Technology, 2017
Computer vision and machine learning are two young and promising technology. Paired together they... more Computer vision and machine learning are two young and promising technology. Paired together they have been in use for inspection, identification, object recognition and many more. Agricultural markets suffer heavily due to the loss caused by diseases. It can be easily prevented if only the farmers and cold storage owners knew what exactly the disease the product is suffering from. With the increasing reach of smartphone, digital cameras have been getting available to the masses. We are aiming to develop algorithms that can detect and estimate the diseases in vegetables and fruits. Such algorithms can be accommodated in smartphones and can potentially change the way the current inspection of the agricultural produces. Here we have tried to identify the key algorithms from recent work that could help us developing more advanced algorithms.
Abstract PS18-24: Impact of protein corona formation on Fn14-targeted DART nanoparticle selectivity, uptake, and cytotoxicity on TNBC cells
Cancer Research, 2021
Despite dramatic improvements in the treatment of primary breast cancers, there currently are no ... more Despite dramatic improvements in the treatment of primary breast cancers, there currently are no effective targeted therapeutics for women diagnosed with metastatic triple negative breast cancer (mTNBC), resulting in an overall survival of just ~13 months in these patients. Drug-loaded nanoparticles (NPs) offer the potential to improve the therapeutic efficacy and pharmacokinetic profile of drugs through use of passive and active targeting to metastatic tumors. However, effective and active targeting of nanodrug formulations to tumor cells is complicated by the adsorption of proteins to NP surfaces upon exposure to the systemic circulation. Termed ‘protein coronas’, this protein coat can drastically reduce the blood circulation time and targeting capability of NPs in vivo. We have developed paclitaxel (PTX)-loaded NPs that are engineered for decreased non-specific adhesivity and receptor-targeting (‘DART’) characteristics, which balance minimal recognition by circulating immune cell...
Critical Cliques and Their Application to Influence Maximization in Online Social Networks. (May ... more Critical Cliques and Their Application to Influence Maximization in Online Social Networks. (May 2012) Nikhil Pandey, B.Tech., Motilal Nehru National Institute of Technology Chair of Advisory Committee: Dr. Jianer Chen Graph decompositions have useful applications in optimization problems that are categorized as NP-Hard. Modular Decomposition of a graph is a technique to decompose the graph into non-overlapping modules. A module M of an undirected graph G = (V,E) is commonly defined as a set of vertices such that any vertex outside of M is either adjacent or non-adjacent to all vertices in M . By the theory of modular decomposition, the modules can be categorized as parallel, series or prime modules. Series modules which are maximal and are also cliques are termed as simple series modules or critical cliques. There are modular decomposition algorithms that can be used to decompose the graph into modules and obtain critical cliques. In this current research, we present a new algorith...
Impact of Plug-in Electric Vehicle on Residential Demand Side Management
2020 International Conference on Power Electronics & IoT Applications in Renewable Energy and its Control (PARC), 2020
In the recent time because of increasing demand, sub stations are spending extra amount on peaker... more In the recent time because of increasing demand, sub stations are spending extra amount on peaker power plant to meet the consumer demand and since Plug-in Electric vehicle (PEV) are the future of automobiles it can be used to manage the demand supply without compromising the customer needs. This paper investigates the impact and integration of PEV in Demand side Management (DSM). The main contribution of this study is to schedule shift-able loads to achieve the target of minimum pressure on grid. We presented the algorithm to manage the demand profile of consumer and the based on study the MATLAB simulation results are obtained.
Zhiwei Xie1, Parth Jadeja2, Jyothi U. Menon2, Dheeraj Thakore2, Nikhil Pandey2, Jian Yang1*, Kyta... more Zhiwei Xie1, Parth Jadeja2, Jyothi U. Menon2, Dheeraj Thakore2, Nikhil Pandey2, Jian Yang1*, Kytai T. Nguyen2* 1 Department of Biomedical Engineering, Materials Research Institute, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, 16802. * Email: [email protected] 2 Department of Bioengineering, The University of Texas at Arlington, Arlington, TX. * Email: [email protected] Statement of Purpose: Current cancer management is dedicated in developing new techniques for earlier diagnosis and controlled drug delivery. Common diagnostic modalities such as magnetic resonance imaging (MRI), positron emission tomography, and optical imaging all individually have different limitations such as low sensitivity, low spatial resolution, toxicity of contrast agents, and inaccurate diagnosis. Dual-/multi-modal imaging systems may overcome these limitations by taking advantages of various individual techniques. For instance, MRI provides exceptional tissue contrast, pen...
Acute Respiratory Distress Syndrome is a familiar and destructive clinical condition characterize... more Acute Respiratory Distress Syndrome is a familiar and destructive clinical condition characterized by progressive, swift and impaired pulmonary state. It leads to mortality if not managed in a timely manner. Recently the role of imbalanced macrophage polarization has been reported in ARDS. Macrophages are known for their heterogeneity and plasticity. Under different microenvironmental stimuli, they (M0) can switch between classically activated macrophage (M1) and alternatively activated (M2) states. This switch is regulated by several signaling pathways and epigenetic changes. In this review, the importance of macrophage M1 and M2 has been discussed in the arena of ARDS citing the phase-wise impact of macrophage polarization. This will provide a further understanding of the molecular mechanism involved in ARDS and will help in developing novel therapeutic targets. Various biomarkers that are currently used concerning this pathophysiological feature have also been summarized.
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