ARTIC Technologies

Great news to share: ARTIC has received a Rabobank Innovatielening (RIL)! The RIL is an important addition to our pre-seed round and helps us accelerate the development and validation of our scalable flow-enabled cell culture platform. Over the coming months, it will support key biological validation studies, commercial pilot projects, and further product development as we work towards bringing our solution to market in 2028. Many thanks to the Rabobank for the confidence and for supporting innovative companies at an early stage. A special thank you to Michel Ziekman for his guidance and support throughout the process, much appreciated. We're looking forward to the next phase of growth and to continuing our mission: enabling scientists to create better cell models, making advanced in vitro research more accessible and scalable. #MicrophysiologicalSystem #CellCulture #HighThroughput #ComplexInVitroModels #Flow #NewApproachMethodologies #Reproducibility #3DCellCulture

Deze video moet je zeker even bekijken. Wat je ziet: het resultaat van Onderzoeksprogramma Perspectief - Efficiëntere medicijnontwikkeling met SMART Organ-on-Chip. En dit maakt duidelijk hoe beperkt de huidige wetenschap (veelal met dierproeven) is, en hoe ontzettend veel beter het kan als we gebruikmaken van nieuwe technologie. En je komt ook nog een bekende tegen uit de Proefdiervrij Venture Challenge - ARTIC Technologies. 𝐍𝐖𝐎 𝐬𝐭𝐞𝐥𝐭: "Nederland loopt wereldwijd voorop in het ontwikkelen van organs-on-chip: stukjes levend menselijk weefsel die een orgaan nabootsen. Hiermee kun je bijvoorbeeld de werking en toxiciteit van medicijnen testen. Elk lab ontwikkelt echter zijn eigen chips. Het Perspectiefprogramma SMART Organ-on-Chip zet de eerste stappen naar standaardisatie, en daarmee naar grootschaliger gebruik van deze technologie die dierproeven kan vervangen." 𝐑𝐞𝐚𝐜𝐭𝐢𝐞 𝐯𝐚𝐧 𝐨𝐧𝐳𝐞 𝐝𝐢𝐫𝐞𝐜𝐭𝐞𝐮𝐫 𝐃𝐞𝐛𝐛𝐲 𝐖𝐞𝐢𝐣𝐞𝐫𝐬: "Wat een mooie video en vooral: een super project! Ik ben blij dat we hier met Proefdiervrij een bijdrage aan kunnen leveren. Daarnaast heel gaaf om te zien dat startup ARTIC, alumnus van de Proefdiervrij Venture Challenge, hier mag shinen! Keep up the good work!"

Caco-2 is not outdated in many cases. But the way we use it may need an upgrade. A nice paper by Dong Ye et al. shows why permeability prediction becomes difficult when we move beyond “easy” small molecules. For poorly soluble and/or poorly permeable compounds, standard static Caco-2 assays can struggle to provide realistic readouts. The authors explored a mucin-protected Caco-2 assay combined with complex biorelevant media, including #TIM-derived #IntestinalFluids, to better study #DrugPermeation under physiologically relevant conditions. A very relevant point: #ApparentPermeability is not only about the cell layer. It is also shaped by the assay environment: mucus interactions, medium composition, prandial state, solubility limitations, and even the unstirred water layer. This is exactly where we believe the next generation of #GutPermeability models should focus: → keeping the scalability and familiarity of Transwell-based Caco-2 workflows → adding more physiological conditions, such as mucus and biorelevant intestinal fluids → using controlled flow to reduce static artefacts and better mimic the intestinal environment → improving robustness for difficult-to-assess molecules, including low-solubility and/or low-permeability compounds At ARTIC, we are developing dynamic Transwell-based gut models designed to bring physiological flow into standard lab workflows — without adding unnecessary operational complexity. Are you working on challenging molecules in gut permeability, food-effect, or ADME studies? Contact us (info@artic.technology) or send us a message on LinkedIn to have a chat. Hossein Amirabadi, Laure van der Sanden, Jaap den Toonder, Marie Monchablon, Andres Pasetti Roza, Sander de Vos, Emre Dilmen, Guus van Huijgevoort, Ganesh Kadamur, Lara C. Nold #Caco2 #DrugPermeability #Bioavailability #ADME #GutModels #BiorelevantMedia #TIM #NAMs #MPS #MicrophysiologicalSystems #OrganOnChip #InVitroModels #DrugDevelopment #PreclinicalModels #FoodEffect #Transwell

Very happy and proud to have Brabant Startup Fonds BV onboard since last year! Their continued support and insights played a key role in progressing to our first industrial paid pilots, but also help us to sharpen our proposition and investment strategy. Thanks a lot Noud Steffens and Gerard Spanbroek! Sam Wouters thanks for listening to our story and managing to translate it to a well understandable, mostly jargon free article 😄 Interested in reading the full article (in Dutch)? Follow this link: https://lnkd.in/ewX3yZ2t

“Het Perspectief-programma vervult een essentiële brugfunctie tussen fundamenteel onderzoek en het vermarkten van ontwikkelde producten”, reageerde Marcel Levi vorige maand op het besluit van het ministerie van Economische Zaken en Klimaat stopt met de financiering van het Perspectief-programma. Die essentiële brugfunctie is onder andere te zien bij het Perspectief-project SMART Organ-on-Chip, onder leiding van Jaap den Toonder. In dit project werken kennisinstellingen en eindgebruikers, waaronder TNO samen aan een cruciale stap in de ontwikkeling van organ-on-chip: standaardisatie. Organ-on-chip-technologie maakt het mogelijk om miniatuurmodellen te bouwen van menselijke organen. Daarmee kan bijvoorbeeld de werking en toxiciteit van medicijnen getest worden. Dat maakt het proces goedkoper, efficiënter en het draagt bij aan het verminderen van dierproeven. Hoewel Nederland wereldwijd koploper is op de technologie, blijft de brede toepassing nog achter. Elk lab ontwikkelt namelijk zijn eigen chip, met eigen formaten en aansluitingen. Juist in deze ontwikkelfase wordt het verschil gemaakt. Door eindgebruikers vanaf het begin te betrekken en via een industriële adviesraad continue te toetsen aan praktijkbehoeften, ontstaan oplossingen die niet alleen innovatief zijn, maar ook toepasbaar.   Het resultaat: een proof of concept en prototype voor een gestandaardiseerd organ-on-chip platform, nieuwe modules en zelfs een startup ARTIC Technologies. Dit is de kracht van Perspectief: hier wordt de brug geslagen van veelbelovend onderzoek naar werkende innovaties met maatschappelijke impact. Benieuwd naar het volledige verhaal? Lees en kijk de case hier: https://lnkd.in/dUHiATxj

#Bioavailability prediction remains a challenge. A nice comparative study by Moyer et al. looked at Caco-2, primary human enteroid-derived cells, and #MPS models for intestinal permeability and oral bioavailability prediction. An important take-away: more complex or more physiologically advanced models do not automatically lead to better predictive performance. Context of use matters. For highly permeable small molecules, conventional Caco-2 can still perform very well. But the bigger question is: what happens when permeability becomes the actual bottleneck? That is where many teams run into challenges with low-permeability and/or low-solubility molecules, especially when they want to combine physiological relevance with scalable, reproducible, industry-compatible workflows. Are you working on difficult-to-assess molecules in gut permeability or ADME screening? Let’s connect. At ARTIC, this is exactly the space we are working in: dynamic gut permeability models that add controlled flow while staying close to standard Transwell-based lab workflows. Contact our scientific lead Hossein Amirabadi (info@artic.technology) or send us a message on LinkedIn to have a chat. Link to the paper: https://lnkd.in/ewMyAq-N. Hossein Amirabadi, Laure van der Sanden, Jaap den Toonder, Marie Monchablon, Andres Pasetti Roza, Sander de Vos, Emre Dilmen, Guus van Huijgevoort, Ganesh Kadamur, Lara C. Nold #DrugPermeability #Bioavailability #ADME #Caco2 #GutModels #NAMs #MicrophysiologicalSystems #MPS #InVitroModels #DrugDevelopment #PreclinicalModels

On a field trip! Today we started our second customer pilot, this time right at home! 🧡 We are very happy to start working with this unique company and start this exciting project with them. Are you working in #GutPermeability and interested in trying our easy-to-use, dynamic platform? We'd love to get introduced!

Yesterday our CTO Hossein Amirabadi presented our scalable cell culture platform with flow to the InnovationLab GmbH community on this beautiful stage at GENESIS 26 – The Life Science Tech Day in Heidelberg. Great opportunity for us to explain the benefits of our platform for gut Transwell applications, and organs beyond. We loved meeting and talking with end users and people active in the field. Thanks a lot for the invitation Reza Taale and colleagues, and Laura Windt and Health Holland for connecting us. Much appreciated and well enjoyed! Interested in testing our system for your Transwell, or other, use cases? Reach out directly to info@artic.technology! #MicrophysiologicalSystem #CellCulture #HighThroughput #ComplexInVitroModels #Flow #Reproducibility #3DCellCulture #Organoids Laure van der Sanden | Jaap den Toonder | Marie Monchablon | Andres Pasetti Roza | Guus van Huijgevoort | Sander de Vos | Emre Dilmen | Ganesh Kadamur | Microsystems TU/e

This week, our CEO Laure van der Sanden will be in Basel for the health.tech | global summit 2026. At ARTIC, we’re building a new category of in vitro gut models, combining physiological flow with the ease of use and scalability of standard well plates. For CROs and R&D teams in biotech and pharma, this means: • More predictive permeability data • Better translation to in vivo • No complex microfluidic infrastructure We enable scientists create better cell models, without the burden of operational complexity. At the summit, we're looking forward to connecting with: • CROs working on ADME / permeability • Pharma & biotech teams developing oral drugs • Life sciences investors interested in next-gen in vitro platforms If you're attending and thinking about better gut models or translational performance, let’s meet! See you in Basel 👋

Our CTO Hossein Amirabadi will present ARTIC at InnovationLab GmbH's GENESIS 26 in Heidelberg on March 12! Looking forward to connect with scientists and end users to understand their challenges around cell culture and MPS! Curious about what we are up to? Read the exciting interview with Hossein here: https://lnkd.in/dufRNyP7 #MicrophysiologicalSystem #CellCulture #HighThroughput #ComplexInVitroModels #Flow #Reproducibility #3DCellCulture #Organoids Laure van der Sanden | Jaap den Toonder | Marie Monchablon | Andres Pasetti Roza | Guus van Huijgevoort | Sander de Vos | Emre Dilmen| Ganesh Kadamur | Microsystems TU/e