Helia Biomonitoring

𝗜𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻 𝗯𝘆 𝗟𝗙-𝘀𝗲𝗹𝗲𝗰𝘁𝗶𝘃𝗲 𝗺𝗶𝗹𝗸 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴   Bovine milk has fluctuating levels of Lactoferrin (LF), often by several tens of mg/L, due to factors such as stage of lactation, milk yield, somatic cell count, microbial exposure, feed intake, animal stress, and environmental conditions.   𝗧𝗵𝗶𝘀 𝗿𝗮𝗶𝘀𝗲𝘀 𝗮𝗻 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁𝗶𝗻𝗴 𝗼𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝘆 𝗳𝗼𝗿 𝗱𝗮𝗶𝗿𝘆 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗼𝗿𝘀: 𝗛𝗼𝘄 𝗰𝗮𝗻 𝗳𝗹𝘂𝗰𝘁𝘂𝗮𝘁𝗶𝗻𝗴 𝗟𝗙 𝗹𝗲𝘃𝗲𝗹𝘀 𝗯𝗲 𝗲𝘅𝗽𝗹𝗼𝗶𝘁𝗲𝗱 𝘁𝗼 𝗶𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝘁𝗵𝗲 𝗟𝗙 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻?   With the Helia Atline Lactoferrin Analyzer, it is possible to identify and selectively direct high-LF milk toward LF extraction. The figure below illustrates this principle. By implementing LF-based milk selection, the average LF concentration in the processed milk increases significantly: –   LF measurements of milk tanks result in up to 𝟳% 𝗺𝗼𝗿𝗲 𝗟𝗙 in the selected milk –   LF measurements of milk trucks result in up to 𝟮𝟳% 𝗺𝗼𝗿𝗲 𝗟𝗙 in the selected milk   We will be happy to speak with you about the opportunities of LF-selective milk processing and how it can be implemented in your manufacturing!   #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗜𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻 𝗯𝘆 𝗟𝗙-𝘀𝗲𝗹𝗲𝗰𝘁𝗶𝘃𝗲 𝗺𝗶𝗹𝗸 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴   Bovine milk has fluctuating levels of Lactoferrin (LF), often by several tens of mg/L, due to factors such as stage of lactation, milk yield, somatic cell count, microbial exposure, feed intake, animal stress, and environmental conditions.   𝗧𝗵𝗶𝘀 𝗿𝗮𝗶𝘀𝗲𝘀 𝗮𝗻 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁𝗶𝗻𝗴 𝗼𝗽𝗽𝗼𝗿𝘁𝘂𝗻𝗶𝘁𝘆 𝗳𝗼𝗿 𝗱𝗮𝗶𝗿𝘆 𝗽𝗿𝗼𝗰𝗲𝘀𝘀𝗼𝗿𝘀: 𝗛𝗼𝘄 𝗰𝗮𝗻 𝗳𝗹𝘂𝗰𝘁𝘂𝗮𝘁𝗶𝗻𝗴 𝗟𝗙 𝗹𝗲𝘃𝗲𝗹𝘀 𝗯𝗲 𝗲𝘅𝗽𝗹𝗼𝗶𝘁𝗲𝗱 𝘁𝗼 𝗶𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝘁𝗵𝗲 𝗟𝗙 𝗽𝗿𝗼𝗱𝘂𝗰𝘁𝗶𝗼𝗻?   With the Helia Atline Lactoferrin Analyzer, it is possible to identify and selectively direct high-LF milk toward LF extraction. The figure below illustrates this principle. By implementing LF-based milk selection, the average LF concentration in the processed milk increases significantly: –   LF measurements of milk tanks result in up to 𝟳% 𝗺𝗼𝗿𝗲 𝗟𝗙 in the selected milk –   LF measurements of milk trucks result in up to 𝟮𝟳% 𝗺𝗼𝗿𝗲 𝗟𝗙 in the selected milk   We will be happy to speak with you about the opportunities of LF-selective milk processing and how it can be implemented in your manufacturing!   #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗗𝗶𝘃𝗲𝗿𝘀𝗲 𝘁𝘆𝗽𝗲𝘀 𝗼𝗳 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝘀𝗮𝗺𝗽𝗹𝗲𝘀 𝗺𝗲𝗮𝘀𝘂𝗿𝗲𝗱 𝗶𝗻 𝘁𝗵𝗲 𝗛𝗲𝗹𝗶𝗮 𝗔𝘁𝗹𝗶𝗻𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗔𝗻𝗮𝗹𝘆𝘇𝗲𝗿 Diverse types of samples from Lactoferrin extraction processes (raw milk, inlet skim milk, outlet skim milk, LPO eluate, LF eluate, LF powder) are compatible with the Helia Atline Lactoferrin Analyzer. All samples are measured in the Analyzer by applying the same simple step: sample dilution in a buffer.   The matrix compatibility of diverse sample types is demonstrated by measuring a dilution series (see graphs). For all sample types, the measured concentration decreases inversely with the applied dilution factor, which proves the absence of matrix interferences. These results demonstrate that the Helia Analyzer simplifies Lactoferrin analysis and delivers robust measurements throughout the production process.   Next week: insights into business cases for measuring raw milk   #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗧𝗵𝗲 𝗛𝗲𝗹𝗶𝗮 𝗔𝘁𝗹𝗶𝗻𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗔𝗻𝗮𝗹𝘆𝘇𝗲𝗿 𝗶𝗻𝗰𝗹𝘂𝗱𝗲𝘀 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝘀𝗮𝗺𝗽𝗹𝗲 𝗽𝗿𝗲𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 Measuring levels of native, bioactive Lactoferrin has never been easier. The Helia Atline Lactoferrin Analyzer directly accepts milk samples and process intermediates; no manual sample pretreatment is needed by the operator. All sample pretreatment steps, including dilution, vortex mixing, and heating, are fully automated inside the Analyzer, simplifying your analytical workflow and ensuring highly reproducible measurements.   In tests across multiple skim milk samples, we observed: –   A perfect one-to-one correlation between automated pretreatment and manual pretreatment –   Automated sample pretreatment gives the best reproducibility: 3.4% These results show that the Helia Atline Analyzer delivers consistent, reliable measurements, making process monitoring and control easier than ever. Next post: How the Helia Atline Analyzer handles different sample types.   #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗧𝗵𝗲 𝗛𝗲𝗹𝗶𝗮 𝗔𝘁𝗹𝗶𝗻𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗔𝗻𝗮𝗹𝘆𝘇𝗲𝗿 𝗶𝗻𝗰𝗹𝘂𝗱𝗲𝘀 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝘀𝗮𝗺𝗽𝗹𝗲 𝗽𝗿𝗲𝘁𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 Measuring levels of native, bioactive Lactoferrin has never been easier. The Helia Atline Lactoferrin Analyzer directly accepts milk samples and process intermediates; no manual sample pretreatment is needed by the operator. All sample pretreatment steps, including dilution, vortex mixing, and heating, are fully automated inside the Analyzer, simplifying your analytical workflow and ensuring highly reproducible measurements.   In tests across multiple skim milk samples, we observed: –   A perfect one-to-one correlation between automated pretreatment and manual pretreatment –   Automated sample pretreatment gives the best reproducibility: 3.4% These results show that the Helia Atline Analyzer delivers consistent, reliable measurements, making process monitoring and control easier than ever. Next post: How the Helia Atline Analyzer handles different sample types.   #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗧𝗵𝗲 𝗛𝗲𝗹𝗶𝗮 𝗔𝘁𝗹𝗶𝗻𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗔𝗻𝗮𝗹𝘆𝘇𝗲𝗿 𝗺𝗲𝗮𝘀𝘂𝗿𝗲𝘀 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰𝗮𝗹𝗹𝘆 𝗻𝗮𝘁𝗶𝘃𝗲, 𝗯𝗶𝗼𝗮𝗰𝘁𝗶𝘃𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 Native, bioactive Lactoferrin delivers essential health benefits and has the highest commercial value among all Lactoferrin types. To demonstrate the specificity of the Helia Atline Lactoferrin Analyzer, we measured Lactoferrin levels in native skim milk and in skim milk after a brief heat treatment: –     Native skim milk → measured LF-concentration: 120 mg/L –     Heat-treated skim milk → measured LF-concentration: below 0.5 mg/L (below the detection limit) These results confirm that the Helia Atline Lactoferrin Analyzer achieves a specificity of >99.6% for detecting native, bioactive Lactoferrin rather than heat-deactivated Lactoferrin. Therefore, the Helia Atline LF Analyzer is suited for process control and quality control applications during Lactoferrin production. Next post: Discover how the Analyzer includes automated flexible dilution, making precise, real-time measurements easier than ever.   #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗦𝗲𝗻𝘀𝗶𝘁𝗶𝘃𝗶𝘁𝘆 𝗮𝗻𝗱 𝗥𝗲𝗽𝗿𝗼𝗱𝘂𝗰𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗼𝗳 𝘁𝗵𝗲 𝗔𝘁𝗹𝗶𝗻𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗔𝗻𝗮𝗹𝘆𝘇𝗲𝗿 The Helia Atline Lactoferrin Analyzer enables the quantification of native, bioactive Lactoferrin across a broad concentration range of 1-1000 mg/L. This wide dynamic range is achieved by a fully automated sample dilution inside the instrument, with dilution factors between 100x and 10,000x. The dilution brings the Lactoferrin concentration in the range between 10-40 µg/L where the resulting Lactoferrin concentration is then reliably quantified.   𝗞𝗲𝘆 𝗮𝗻𝗮𝗹𝘆𝘁𝗶𝗰𝗮𝗹 𝗽𝗲𝗿𝗳𝗼𝗿𝗺𝗮𝗻𝗰𝗲 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀: • Effective measurement range: 1-1000 mg/L due to flexible dilution • Reproducibility: 4% RSD at 100 mg/L, determined over multiple days and multiple instruments Next post: A dive into the specificity of the sensor. The sensor measures native, bioactive Lactoferrin, rather than denatured Lactoferrin. #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗦𝗲𝗻𝘀𝗶𝘁𝗶𝘃𝗶𝘁𝘆 𝗮𝗻𝗱 𝗥𝗲𝗽𝗿𝗼𝗱𝘂𝗰𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗼𝗳 𝘁𝗵𝗲 𝗔𝘁𝗹𝗶𝗻𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗔𝗻𝗮𝗹𝘆𝘇𝗲𝗿 The Helia Atline Lactoferrin Analyzer enables the quantification of native, bioactive Lactoferrin across a broad concentration range of 1-1000 mg/L. This wide dynamic range is achieved by a fully automated sample dilution inside the instrument, with dilution factors between 100x and 10,000x. The dilution brings the Lactoferrin concentration in the range between 10-40 µg/L where the resulting Lactoferrin concentration is then reliably quantified.   𝗞𝗲𝘆 𝗮𝗻𝗮𝗹𝘆𝘁𝗶𝗰𝗮𝗹 𝗽𝗲𝗿𝗳𝗼𝗿𝗺𝗮𝗻𝗰𝗲 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀: • Effective measurement range: 1-1000 mg/L due to flexible dilution • Reproducibility: 4% RSD at 100 mg/L, determined over multiple days and multiple instruments Next post: A dive into the specificity of the sensor. The sensor measures native, bioactive Lactoferrin, rather than denatured Lactoferrin. #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗙𝗮𝘀𝘁, 𝗽𝗿𝗲𝗰𝗶𝘀𝗲, 𝗮𝗻𝗱 𝗮𝗰𝗰𝘂𝗿𝗮𝘁𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗺𝗲𝗮𝘀𝘂𝗿𝗲𝗺𝗲𝗻𝘁𝘀. The Helia Atline Lactoferrin Analyzer provides you with reliable, real-time biomolecular insights for increasing the yield and efficiency of your bioprocess. 𝗞𝗲𝘆 𝘀𝘆𝘀𝘁𝗲𝗺 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻𝘀:   –     Target: native bioactive Lactoferrin –     Time-to-result: 10 minutes –     Sample volume: 100 µL or more –     Measurement range: 1 mg/L - 1 g/L, 1-1000 ppm –     Sample supply: single sample to tens of samples –     Reproducibility: 4% (inlet skim milk samples) –     Footprint (W x D x H): 80 x 50 x 75 cm Increase yield. Boost efficiency. Stay ahead of fluctuations. The Atline Lactoferrin Analyzer is ready for testing! Next post: A deeper dive into the analytical performance, including sensitivity, precision, and reproducibility. #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer, #AnalyticalPerformance

𝗗𝗼 𝘆𝗼𝘂 𝘄𝗮𝗻𝘁 𝘁𝗼 𝗲𝘅𝘁𝗿𝗮𝗰𝘁 𝗺𝗼𝗿𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗳𝗿𝗼𝗺 𝘆𝗼𝘂𝗿 𝗺𝗶𝗹𝗸, 𝗲𝘃𝗲𝗿𝘆 𝘀𝗶𝗻𝗴𝗹𝗲 𝗱𝗮𝘆 𝗼𝗳 𝘁𝗵𝗲 𝘆𝗲𝗮𝗿? The Helia Atline Lactoferrin Analyzer measures Lactoferrin in real time, so you can maximize the yield and efficiency of your extraction process. Every tank of milk, each day of the year. 𝗪𝗵𝘆 𝗶𝘁 𝘄𝗼𝗿𝗸𝘀: –          Immediate process feedback –          Continuous, real-time monitoring, 24/7 operation –          No specialized expertise needed, fully automated –          Flexible and cost-effective 𝗜𝗻𝗰𝗿𝗲𝗮𝘀𝗲 𝘆𝗶𝗲𝗹𝗱. 𝗕𝗼𝗼𝘀𝘁 𝗲𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝗰𝘆. 𝗦𝘁𝗮𝘆 𝗮𝗵𝗲𝗮𝗱 𝗼𝗳 𝗳𝗹𝘂𝗰𝘁𝘂𝗮𝘁𝗶𝗼𝗻𝘀. 𝗧𝗵𝗲 𝗔𝘁𝗹𝗶𝗻𝗲 𝗟𝗮𝗰𝘁𝗼𝗳𝗲𝗿𝗿𝗶𝗻 𝗔𝗻𝗮𝗹𝘆𝘇𝗲𝗿 𝗶𝘀 𝗿𝗲𝗮𝗱𝘆 𝗳𝗼𝗿 𝘁𝗲𝘀𝘁𝗶𝗻𝗴! Next post: A close look at system specifications and analytical performance. #Bioprocessing, #BioprocessControl, #ProcessAnalyticalTechnology, #RealTimeAnalytics, #RealTimeMonitoring, #ProcessMonitoring, #InProcessMonitoring, #BioprocessInnovation, #Lactoferrin, #ProteinProduction, #AtlineAnalyzer, #ProcessAnalyzer