Alina Şovrea

Unusual renal carcinoma with a double component: case report and review of the literature

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2009

The authors report a rare case of a 60-year-old man who had in his left kidney a tumor with two d... more

State of the art in human adipose stem cells and their role in therapy

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2019

Nowadays, adipose tissue appears to be the most valuable source in regenerative cell therapy, due... more Nowadays, adipose tissue appears to be the most valuable source in regenerative cell therapy, due to the following characteristics: high accessibility, high expression in a large number of individuals, high self-renewal and ability to differentiate, and hematopoietic support to the implant area. Its therapeutic potential has been experimentally observed in a broad spectrum of diseases with high population impact: diabetes, myocardial infarction, Parkinson disease, bone fractures, facial reconstruction or loss of subcutaneous tissue due to congenital abnormalities (e.g., hemifacial microsomy), trauma, burns, and tumors. Over 130 clinical trials using adipose-derived stem cells (ASCs), majority phase I or phase II, have been registered with the National Institutes of Health (NIH), and in the short term no adverse reactions or significant risks were identified. Parallel with regulatory frameworks that control their safety and assess their efficacy, phase III trials are being developed....

format_quoteYoung donors show heightened ASCs differentiation capabilities, while older patients exhibit site-specific responsiveness.format_quote

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Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia

Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerfu... more Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerful antioxidant effect. The aim of the present study was to determine whether MEL protects the brain tissue from the oxidative stress induced by hypobaric hypoxia (HH) in vivo. This study was performed on Wistar rats randomly assigned in four groups, according to the pressure conditions and treatment: Group 1: normoxia and placebo; Group 2: HH and placebo; Group 3: normoxia and MEL; and Group 4: HH and MEL. The following aspects were evaluated: cognitive function (space reference and memory), oxidative stress parameters - serum and brain malondialdehyde (MDA) and reduced glutathione (GSH) levels -, and brain tissue macroscopic and microscopic morphological changes. Exposure to oxidative stress results in cognitive dysfunctions and biochemical alterations: significant increase of MDA and reduction of GSH in both serum and brain tissue. The most important morphological changes were observed ...

format_quoteMEL demonstrated neuroprotective effects against oxidative stress, potentially useful for hypoxia-induced cognitive deficits.format_quote

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Hemorrhagic polypoid gastric and colonic metastases nine years after uterine leiomyosarcoma - case report

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2017

Uterine leiomyosarcoma (ULMS) is a rare tumor, representing 1-2% of all uterine malignancies. It ... more Uterine leiomyosarcoma (ULMS) is a rare tumor, representing 1-2% of all uterine malignancies. It is highly aggressive, with high metastatic rate, especially in lungs, peritoneal cavity, retroperitoneum, bones and liver, usually during the first years after diagnosis. A 58-year-old woman, with subtotal hysterectomy and bilateral adnexectomy, followed by radiochemotherapy for spindle-type ULMS nine years ago, presented with gastrointestinal bleeding and severe anemia. Three polyps ranging from 2 cm to 5 cm in diameter were found at gastroscopy, the largest being ulcerated, which required a total gastrectomy three months later. Colonoscopy identified two pedunculated polyps on the descending colon, 2 cm and 3.5 cm in diameter. Histologically, both sites revealed proliferations of spindle cells with whorled pattern, moderate to severe nuclear atypia, 5 to 8 mitotic figures (MFs)÷10 high-power fields (HPFs) and additional necrosis in the gastric tumors. Immunohistochemistry was negative ...

Diagnostic reevaluation of 17 cases of pheochromocytoma - a retrospective study

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2016

A rare neuroendocrine tumor, the pheochromocytoma (PCC) raises problems due both the limited expe... more A rare neuroendocrine tumor, the pheochromocytoma (PCC) raises problems due both the limited experience of the researchers in this field and its pathogenic mechanisms, still not fully elucidated. The malignant potential of this tumor cannot be predicted based on its macro- or microscopic aspects, but on the presence of metastases. The aims of this study were: (1) the reevaluation of data for a pertinent and complete tumor diagnostic and prognostic pattern; (2) the statistical correlation of all investigated parameters with the malignant form and the survival rate in order to obtain a possible predictor of malignancy; (3) the potential identification of initially diagnosed benign tumors that become malignant in time. The retrospective study was conducted on 17 patients diagnosed with pheochromocytoma. We investigated: the personal data, the associated neuroendocrine syndromes, the clinical, the laboratory, the macro- and microscopic data [location, size, Hematoxylin-Eosin (HE) pheoch...

Pediatric glioblastoma with giant cells and "supratentorial" primitive neuroectodermal component - case report and review of the literature

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2015

The glial differentiation in pediatric "supratentorial primitive neuroectodermal tumors&quot... more The glial differentiation in pediatric "supratentorial primitive neuroectodermal tumors" (sPNET) is occasionally revealed by immunohistochemistry with GFAP (glial fibrillary acidic protein) as isolated positive cells among undifferentiated cells, indicative of divergent cellular phenotypes. Large malignant glial tumors in sPNETs are extremely rare and challenge the neuropathologist by raising the possibility of glioblastomas with sPNET-like features (GB sPNET). The distinction between them is important because of their different treatment and prognostic. A large parieto-occipital tumor with minimal ventricular invasion, in an 11-year-old girl, with a five-month clinical history, was proven to be a highly malignant biphasic tumor, consisting in a glioblastoma with giant cells, representing 75% of the tumor, and sPNET nodules, with one larger dominant nodule. The immunohistochemistry confirmed positivity for synaptophysin, neurofilament, neuron-specific enolase and CD56 in t...

The prognostic role of EBER in pediatric cancer

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2015

The Epstein-Barr virus (EBV) infection is an endemic disease, over 90% of the population being ex... more The Epstein-Barr virus (EBV) infection is an endemic disease, over 90% of the population being exposed to it by adulthood. EBV is implicated in the etiology of a significant number of neoplasms, which acquire particular features in terms of course and prognosis. Incidence rates are much higher in children. To establish the link between EBV and neoplasms, EBER (Epstein-Barr virus non-encoded RNAs) needs to be highlighted in tumor tissue. The role of EBV in patient response to oncological treatment remains controversial.

Astrocytes reassessment - an evolving concept part one: embryology, biology, morphology and reactivity

Journal of Molecular Psychiatry, 2013

The goal of this review is to integrate -in its two parts -the considerable amount of information... more The goal of this review is to integrate -in its two parts -the considerable amount of information that has accumulated during these recent years over the morphology, biology and functions of astrocytes -first part -and to illustrate the active role of these cells in pathophysiological processes implicated in various psychiatric and neurologic disorderssecond part.

format_quoteThe astrocyte/neuron ratio in the human cortex is approximately 1.65, illustrating increased glial dominance in complex brain evolution.format_quote

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Neuroprotective effect of melatonin in experimentally induced hypobaric hypoxia

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2013

Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerfu... more Melatonin (MEL) is an endogenous neurohormone with many biological functions, including a powerful antioxidant effect. The aim of the present study was to determine whether MEL protects the brain tissue from the oxidative stress induced by hypobaric hypoxia (HH) in vivo. This study was performed on Wistar rats randomly assigned in four groups, according to the pressure conditions and treatment: Group 1: normoxia and placebo; Group 2: HH and placebo; Group 3: normoxia and MEL; and Group 4: HH and MEL. The following aspects were evaluated: cognitive function (space reference and memory), oxidative stress parameters - serum and brain malondialdehyde (MDA) and reduced glutathione (GSH) levels -, and brain tissue macroscopic and microscopic morphological changes. Exposure to oxidative stress results in cognitive dysfunctions and biochemical alterations: significant increase of MDA and reduction of GSH in both serum and brain tissue. The most important morphological changes were observed ...

Modificări Patologice Ale Parenchimului Renal În Urma Administrării Prelungite De CCL4-MODEL Experimental

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... Alina Şovrea 1 , Anne-Marie Chindriş 1 , Renata Vasiu 2, G. Şerban3 , Bianca Boşca1 1-CATEDRA... more

An Experimental Model for Inducing Periodontal Pathology in Rat: Histopathological and Enzymatic Aspects

by Ilea Aranka, Alina Şovrea, Flavia Ruxanda, and Bianca Boşca

Multinucleated Giant Cells Polymorphism in Epulis

by Ilea Aranka, V. Miclaus, Alina Şovrea, and Flavia Ruxanda

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 2015

In the present study we investigated multinucleated giant cells (MGCs) presence, density and morp... more

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The diagnostic value of immunohistochemistry and silver impregnation techniques for characterization of normal, reactive and tumoral astrocytes

by Alina Şovrea and Dan Gheban

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2014

Astrocytes represent a heterogeneous population of specialized glial cells responsible not only f... more Astrocytes represent a heterogeneous population of specialized glial cells responsible not only for accomplishing various important functions in the healthy nervous tissue, but also for reacting to all types of the central nervous system diseases and trauma. GFAP immunostaining is considered to be the most accurate of the routine techniques used for identifying astrocytes; however, silver impregnation techniques, which are inexpensive and approachable, might be a reliable alternative. The present research has brought into question and tried to assess the sensitivity and specificity of these classical methods for identifying and differentiating normal and reactive from tumoral astrocytes. Our study included 10 supratentorial gliomas specimens of various grade and two normal brain samples. We performed a histological study on consecutive seriated sections labeled using four methods: the immunostaining for GFAP (glial fibrillary acidic protein) and the three silver impregnation techniq...

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