Max Talanov

University of Messina, Department of engineering, Post-Doc

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Highly-creative head of the laboratory and associate professor with broad research and industrial experience.
Supervisors: Victor Erokhin, Manuel Mazzara, Salvatore Distefano, and Andrew Adamatzky
Phone: +381645192005
Address: Fruškogorska 1, Novi Sad, Serbia

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Papers by Max Talanov

Neuropunk Revolution: Further Results

Studies in computational intelligence, 2024

Neuropunk revolution: memristive model orchestrated implants infrastructure

Neuropunk revolution in short

International Journal of Parallel, Emergent and Distributed Systems

The &quot;neuropunk revolution&quot; represents an innovative approach focused on the int... more The &quot;neuropunk revolution&quot; represents an innovative approach focused on the integration of human-machine interfaces through nerve and neural pathways. This cutting-edge concept seeks to push the boundaries of human-machine interaction by exploring the intricate connections between the human nervous system and artificial technologies. Neuropunk delves into the realm of cyborg technologies, blurring the lines between humans and machines and opening up new possibilities for augmenting human capabilities. By tapping into nerve and neural pathways, neuropunk envisions a future where individuals can seamlessly interface with technology, leading to enhanced sensory perception, cognitive abilities, and physical performance. This concept encapsulates a rebellious and unconventional spirit, challenging traditional notions of the human body and its relationship with technology. This paper discusses the challenges and potential of neuropunk, exploring the fusion of scientific exploration, technological innovation, and a punk-inspired ethos in advancing human-machine integration. It highlights the emergence of real-time neurosimulations and neuromorphic computing as key tools to achieve these aspirations. Additionally, the integration of neurological and hormonal bioinspiration is examined as a promising approach to the design of neural interfaces, fostering more efficient and effective technologies that align better with the human body. Finally, the paper addresses ethical considerations and research tasks to responsibly navigate the neuropunk revolution, ensuring a future that maximizes the benefits of neural interfaces while mitigating potential risks and promoting ethical principles.

Data for: Slime mould: the fundamental mechanisms of biological cognition

Latex Package with all data

Neuropunk revolution: preliminary results

Neurointerface with Oscillator Motifs for inhibitory effect over antagonist muscles for compensation of spastical syndrome

Research Square (Research Square), Jul 12, 2022

The inhibitory management effect is usually underestimated in artificial control systems, using b... more The inhibitory management effect is usually underestimated in artificial control systems, using biological analogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio plausible patterns. We proposed the approach for the compensatory stimulation device in development of previously presented architecture of neurointerface, where (1) neuroport is implemented as DAC and stimulator, (2) neuroterminal-as neurosimulation of a set of oscillator motifs on one-board computer. In the set of experiments with 5 volunteers we measured the efficacy of motor neuron inhibition via antagonist muscle or nerve stimulation registering muscle force with and without antagonist stimulation. For the agonist activation, we used both voluntary activity and electrical stimulation. In the case of stimulation of both agonist and antagonist muscles and nerves, we experimented with delays between muscles stimulation starts in the range 0...20 ms. We registered the subjective discomfort rate. We didn't identify a significant difference between antagonist muscle and nerve stimulation in both voluntary and stimulation of agonist activity. We determined the most effective delay between stimulation of agonist and antagonist muscle/nerve as 10-20 ms.

format_quoteExtensor muscle force significantly decreased to 0.19 ± 0.09 kgf with flexor stimulation at 20 ms delay (p < 0.05).format_quote

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Anthropomorphic Artificial Social Agent with Simulated Emotions and its Implementation

Procedia Computer Science, 2015

In this paper we describe an emotional human-machine interface as an anthropomorphic social agent... more In this paper we describe an emotional human-machine interface as an anthropomorphic social agent able to exhibit simulated emotions and react to emotional stimuli. We propose a neurobiologically inspired agent implementation that is based on mechanics of chemical and physiological processes within human brain. Implementation of model features simulation of neuromodulators such as dopamine, serotonin, and noradrenaline. Demonstration of emotions is achieved via combining aforementioned neuromodulators in different proportions. The Lovheim cube of emotions is used for this purpose. Topic of "uncanny valley" phenomenon and its effect on human-machine interactions is also mentioned. In conclusion of this paper we have proposed realistic computation model allowing us to visualize agents mimics in sync with his speech, and have made a working prototype of aforementioned model.

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The BioDynaMo Project

IGI Global eBooks, 2021

Computer simulations have become a very powerful tool for scientific research. Given the vast com... more Computer simulations have become a very powerful tool for scientific research. Given the vast complexity that comes with many open scientific questions, a purely analytical or experimental approach is often not viable. For example, biological systems comprise an extremely complex organization and heterogeneous interactions across different spatial and temporal scales. In order to facilitate research on such problems, the BioDynaMo project aims at a general platform for computer simulations for biological research. Since scientific investigations require extensive computer resources, this platform should be executable on hybrid cloud computing systems, allowing for the efficient use of state-of-the-art computing technology. This chapter describes challenges during the early stages of the software development process. In particular, we describe issues regarding the implementation and the highly interdisciplinary as well as international nature of the collaboration. Moreover, we explain the methodologies, the approach, and the lessons learned by the team during these first stages.

Towards Anthropo-inspired Computational Systems: the $P^3$ Model

arXiv (Cornell University), Jun 10, 2016

This paper proposes a model which aim is providing a more coherent framework for agents design. W... more This paper proposes a model which aim is providing a more coherent framework for agents design. We identify three closely related anthropo-centered domains working on separate functional levels. Abstracting from human physiology, psychology, and philosophy we create the P 3 model to be used as a multi-tier approach to deal with complex class of problems. The three layers identified in this model have been named PhysioComputing, MindComputing, and MetaComputing. Several instantiations of this model are finally presented related to different IT areas such as artificial intelligence, distributed computing, software and service engineering.

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Neuropunk revolution and its implementation via real-time neurosimulations and their integrations

In this paper I present the perspectives of the “neuropunk revolution” technologies. One could un... more In this paper I present the perspectives of the “neuropunk revolution” technologies. One could understand the “neuropunk revolution” as the integration of real-time neurosimulations into biological nervous/motor system via neurostimulation or artificial robotic systems via integration with actuators. I see the added value of the real-time neurosimulations as bridge technology for the set of developed technologies: BCI, neuroprosthetics, AI, robotics to provide bio-compatible integration into biological or artificial limbs. Here I present the three types of integration of the “neuropunk revolution” technologies as inbound, outbound and closed-loop in-outbound systems. I see the shift of the perspective how we see now the set of technologies including AI, BCI, neuroprosthetics and robotics due to the proposed concept for example the integration of external to a body simulated part of nervous system back into the biological nervous system or muscles.

Simulation of a Central Pattern Generator Using Memristive Devices

Nanobiotechnology reports, Nov 1, 2021

The central pattern generator (CPG) is one of the key elements of the nervous system of Vertebrat... more The central pattern generator (CPG) is one of the key elements of the nervous system of Vertebrates, determining the motor, breathing, swallowing, etc. cyclic motor patterns of a living organism, which require constant maintenance and prompt (or immediate) recovery in the case of injury. In this context, the construction of neuroprosthetic systems requires the development of electronic analogs (the corresponding CPGs). It is proposed to use memristive devices as adaptive elements with continuous tunable characteristics in these systems, because they exhibit a property, similar to bio-synaptic plasticity. The CPG model is developed, which yields an output activity, similar to that of biological objects. The requirements for the temporal characteristics of tunable elements for their successful use as artificial synapses are also specified. Memristive devices of a new type are fabricated according to the Langmuir–Schaefer technique using benzothieno[3,2-b] [1]-benzothiophene (BTBT) dimer as an active layer. BTBT-based devices make it possible to switch the conductivity at low voltages and currents, which is important in the development of energy-efficient neuroprosthetic systems, and the characteristic switching times are about several hundred milliseconds, which indicates that they can be used as analogs of synapses upon instrumental realization of the CPG.

Neuro-Interfaces Review

Journal of Artificial Intelligence and Consciousness

In this paper, we provide a brief description of currently existing neural interfaces such as a b... more In this paper, we provide a brief description of currently existing neural interfaces such as a brain–machine interface, machine–brain interface and bidirectional brain–computer–brain interface. Nevertheless, our aim is not only to provide a review of the current state of the art in these technologies but also to include a philosophical analysis of their fundamental role in the evolution and transformation of cognitive sciences. Also we will show the advantages and disadvantages of different degrees of interface invasiveness. We will highlight the general design schema of them.

Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles

Frontiers in Neuroscience

The effect of inhibitory management is usually underestimated in artificial control systems, usin... more The effect of inhibitory management is usually underestimated in artificial control systems, using biological analogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio-plausible patterns. We proposed an approach for the compensatory stimulation device as implementation of previously presented architecture of the neurointerface, where (1) the neuroport is implemented as a DAC and stimulator, (2) neuroterminal is used for neurosimulation of a set of oscillator motifs on one-board computer. In the set of experiments with five volunteers, we measured the efficacy of motor neuron inhibition via the antagonist muscle or nerve stimulation registering muscle force with and without antagonist stimulation. For the agonist activation, we used both voluntary activity and electrical stimulation. In the case of stimulation of both the agonist and the antagonist muscles and nerves, we experimented with delays between muscle stimulation in t...

Neuropunk Revolution. Hacking Cognitive Systems towards Cyborgs 3.0

arXiv (Cornell University), May 13, 2022

This work is dedicated to the review and perspective of the new direction that we call &quot;... more This work is dedicated to the review and perspective of the new direction that we call &quot;Neuropunk revolution&quot; resembling the cultural phenomenon of cyberpunk. This new phenomenon has its foundations in advances in neuromorphic technologies including memristive and bio-plausible simulations, BCI, and neurointerfaces as well as unconventional approaches to AI and computing in general. We present the review of the current state-of-the-art and our vision of near future development of scientific approaches and future technologies. We call the &quot;Neuropunk revolution&quot; the set of trends that in our view provide the necessary background for the new generation of approaches technologies to integrate the cybernetic objects with biological tissues in close loop system as well as robotic systems inspired by the biological processes again integrated with biological objects. We see bio-plausible simulations implemented by digital computers or spiking networks memristive hardware as promising bridge or middleware between digital and (neuro)biological domains.

Memristive circuit-based model of central pattern generator to reproduce spinal neuronal activity in walking pattern

Frontiers in Neuroscience, 2023

Existing methods of neurorehabilitation include invasive or non-invasive stimulators that are usu... more Existing methods of neurorehabilitation include invasive or non-invasive stimulators that are usually simple digital generators with manually set parameters like pulse width, period, burst duration, and frequency of stimulation series. An obvious lack of adaptation capability of stimulators, as well as poor biocompatibility and high power consumption of prosthetic devices, highlights the need for medical usage of neuromorphic systems including memristive devices. The latter are electrical devices providing a wide range of complex synaptic functionality within a single element. In this study, we propose the memristive schematic capable of self-learning according to bio-plausible spike-timing-dependant plasticity to organize the electrical activity of the walking pattern generated by the central pattern generator.

Deciphering in silico the Role of Mutated NaV1.1 Sodium Channels in Enhancing Trigeminal Nociception in Familial Hemiplegic Migraine Type 3

Frontiers in Cellular Neuroscience

Familial hemiplegic migraine type 3 (FHM3) is caused by gain-of-function mutations in the SCN1A g... more Familial hemiplegic migraine type 3 (FHM3) is caused by gain-of-function mutations in the SCN1A gene that encodes the α1 subunit of voltage-gated NaV1.1 sodium channels. The high level of expression of NaV1.1 channels in peripheral trigeminal neurons may lead to abnormal nociceptive signaling thus contributing to migraine pain. NaV1.1 dysfunction is relevant also for other neurological disorders, foremost epilepsy and stroke that are comorbid with migraine. Here we used computer modeling to test the functional role of FHM3-mutated NaV1.1 channels in mechanisms of trigeminal pain. The activation of Aδ-fibers was studied for two algogens, ATP and 5-HT, operating through P2X3 and 5-HT3 receptors, respectively, at trigeminal nerve terminals. In WT Aδ-fibers of meningeal afferents, NaV1.1 channels efficiently participate in spike generation induced by ATP and 5-HT supported by NaV1.6 channels. Of the various FHM3 mutations tested, the L263V missense mutation, with a longer activation sta...

format_quoteIn silico assessments indicate that mutations in Na V 1.1 channels impact trigeminal nociception differently, potentially aiding in understanding various neurological disorders.format_quote

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The Emotional Mechanisms in NARS

Lecture Notes in Computer Science, 2016

This paper explains the conceptual design and experimental implementation of the components of NA... more This paper explains the conceptual design and experimental implementation of the components of NARS that are directly related to emotion. It is argued that emotion is necessary for an AGI system that has to work with insufficient knowledge and resources. This design is also compared to the other approaches in AGI research, as well as to the relevant aspects in the human brain.

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Concept mining for programming automation

Software engineering is at the very start of it’s automation. There are a lot of helpers, code-ge... more Software engineering is at the very start of it’s automation. There are a lot of helpers, code-generators, IDE-s and so on that does not really help to automate the complete software development life-circle from Functional requirements specification till the actual code. We explore the idea to generate the actual software solution using standard Functional requirements specification, change request or bug-report in three main modules: linguistic, perceiving and solution generation with heavily used knowledge base in OWL (web ontology language).

Automating programming via concept mining, probabilistic reasoning over semantic knowledge base of SE domain

2010 6th Central and Eastern European Software Engineering Conference (CEE-SECR), 2010

Software engineering is at the very start of it's automation. There are a lot of helpers, code-ge... more Software engineering is at the very start of it's automation. There are a lot of helpers, code-generators, IDE-s and so on that does not really help to automate the complete software development life-circle from Functional requirements specification till the actual code. We explore the idea to generate the actual software solution using standard Functional requirements specification, change request or bug-report in three main modules: linguistic, perceiving and solution generation with heavily used knowledge base in OWL (web ontology language).

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The BioDynaMo Project: a platform for computer simulations of biological dynamics

ArXiv, 2016

This paper is a brief update on developments in the BioDynaMo project, a new platform for compute... more This paper is a brief update on developments in the BioDynaMo project, a new platform for computer simulations for biological research. We will discuss the new capabilities of the simulator, important new concepts simulation methodology as well as its numerous applications to the computational biology and nanoscience communities.

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Max Talanov

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