Papers by David de Lorenzo
Perspectivas presentes y futuras de la Nutrigenómica y la Nutrigenética en la medicina preventiva
Nutricion Clinica Y Dietetica Hospitalaria, 2012
Resistance exercise training is widely used to enhance general fitness and athletic potential/cap... more Resistance exercise training is widely used to enhance general fitness and athletic potential/capacity across many sporting disciplines including power, strength and endurance events [1, 2]. When properly performed and combined with adequate nutrition, resistance training leads to increases in strength, power, speed, muscle size, local muscular endurance, coordination, and flexibility and reductions in body fat and blood pressure [3].
Nutrigenómica y nutrigenética en la farmacia
Aula De La Farmacia Revista Profesional De Formacion Continuada, 2012
A genetic-based algorithm for personalized resistance-training
Biology of Sport, 2016
Association studies have identified dozens of genetic variants linked to training responses and s... more Association studies have identified dozens of genetic variants linked to training responses and sport-related traits. However, no intervention studies utilizing the idea of personalised training based on athlete's genetic profile have been conducted. Here we propose an algorithm that allows achieving greater results in response to high- or low-intensity resistance training programs by predicting athlete's potential for the development of power and endurance qualities with the panel of 15 performance-associated gene polymorphisms. To develop and validate such an algorithm we performed two studies in independent cohorts of male athletes (study 1: athletes from different sports (n = 28); study 2: soccer players (n = 39)). In both studies athletes completed an eight-week high- or low-intensity resistance training program, which either matched or mismatched their individual genotype. Two variables of explosive power and aerobic fitness, as measured by the countermovement jump (CMJ) and aerobic 3-min cycle test (Aero3) were assessed pre and post 8 weeks of resistance training. In study 1, the athletes from the matched groups (i.e. high-intensity trained with power genotype or low-intensity trained with endurance genotype) significantly increased results in CMJ (P = 0.0005) and Aero3 (P = 0.0004). Whereas, athletes from the mismatched group (i.e. high-intensity trained with endurance genotype or low-intensity trained with power genotype) demonstrated non-significant improvements in CMJ (P = 0.175) and less prominent results in Aero3 (P = 0.0134). In study 2, soccer players from the matched group also demonstrated significantly greater (P < 0.0001) performance changes in both tests compared to the mismatched group. Among non- or low responders of both studies, 82% of athletes (both for CMJ and Aero3) were from the mismatched group (P < 0.0001). Our results indicate that matching the individual's genotype with the appropriate training modality leads to more effective resistance training. The developed algorithm may be used to guide individualised resistance-training interventions.
Binomios: el m�todo cient�fico y los alimentos transg�nicos
Ciència i universitat a Catalunya. Projecció de futur.
Genes & nutrition, 2013
Vitamin D receptor polymorphisms may predispose that not all individuals could have benefits from... more Vitamin D receptor polymorphisms may predispose that not all individuals could have benefits from the nutritional supplementation of 25-hydroxyvitamin D. Furthermore, vitamin D-related cardiovascular effects may also be influenced by soy isoflavones considered endocrine regulators of cardiovascular homeostasis. To find possible gene-diet interactions by evaluating individualized lipid metabolism benefits from an increase in soy and 25-hydroxyvitamin D intake, 106 healthy individuals, genotyped for vitamin D receptor (VDR) gene polymorphism rs1544410 (BsmI) were randomly assigned to either no intake, to daily 250 mL or 500 mL of a 25-hydroxyvitamin D supplemented SB for 2 months. The soybean beverage induced differences in cardiovascular risk factors (lipid profile, blood pressure, TNFa and MCP-1), as well as vitamin D metabolites in a dose-gene-dependent relation. Thus, VDR BsmI polymorphism affected individual response being the GG genotype the ones that showed dose-dependent manner responsiveness in the reduction in total cholesterol, LDL and triglycerides in comparison with the AA/AG genotype. These differences were associated with increased plasma levels of 1a,25-dyhydroxyvitamin D3 in the carriers of the GG genotype. It was concluded that metabolic response to 25-hydroxyvitamin D and soybean supplementation is dependent on VDR BsmI GG genotype due to a higher conversion rate from vitamin D precursors.
El tabaquismo es uno de los principales problemas de salud pública hoy día, ya que afecta a más d... more El tabaquismo es uno de los principales problemas de salud pública hoy día, ya que afecta a más de 1.200 millones de personas en el mundo, muchas de las cuales morirán por causas derivadas del consumo de tabaco.
Levolució com a coneixement és un dels camps de la ciència que desperta més interès, la qual cosa... more Levolució com a coneixement és un dels camps de la ciència que desperta més interès, la qual cosa no implica que sigui el més entès i conegut. Ans al contrari; el lector probablement haurà sentit expressions com que levolució és simplement ladquisició de millors característiques físiques, que els micos que veiem actualment són els nostres antecessors, o que no existeix cap organisme més evolucionat que lésser humà. Tanmateix, sabem que moltes espècies es van extingir, el que implica que levolució és quelcom més complex que millorar al llarg del temps. També sabem que els micos actuals han sofert un procés devolució i per tant la nostra relació amb ells és més aviat de cosins llunyans més que dascendents-descendents. Curiosament, però, sembla que lhome presenta una de les menors taxes de canvi (nombre de canvis per unitat de temps), amb la qual cosa es dedueix que lhome és menys evolucionat que altres dels seus congèneres primats. .inalment, tot i que és cert que la nostra capacitat mental és clarament superior a la daltres éssers vius, existeix també un elevat grau de complexitat en el mecanisme en què les plantes transformen la llum i el diòxid de carboni en matèria viva, que no és menys sofisticat que aquells que observem en la nostra espècie.
Genoms. Die Punkte stellen die gemessenen Heterozygotie-Werte an den einzelnen Genorten dar.
Las enfermedades no infecciosas, principalmente derivadas de una mala alimentación han reemplazad... more Las enfermedades no infecciosas, principalmente derivadas de una mala alimentación han reemplazado a las enfermedades infecciosas como principal causa de mortalidad. Durante los últimos años se ha extendido el concepto de dietas personalizadas como la solución a los trastornos de la salud derivados de una mala alimentación. ¿Hasta qué punto está preparada la ciencia de la Genómica Nutricional y los profesionales que con ella trabajan, para dar respuesta a esta necesidad? Este artículo de revisión da una visión general del actual estado del conocimiento sobre los factores genómicos, epigenómicos, metagenómicos y nutricionales que deberían permitir la personalización de la dieta para reducir el riesgo individual a la enfermedad, para así establecer el potencial actual y las perspectivas de la Genómica Nutricional como herramienta de la medicina preventiva en el mantenimiento de la salud. Se propone también el camino a seguir, así como posibles cuestiones éticas a considerar.
Journal of Psychiatric Research, 2009
The association between different impulsive-disinhibited personality traits with 5-HTTLPR and 5-H... more The association between different impulsive-disinhibited personality traits with 5-HTTLPR and 5-HTTVNTR genetic polymorphisms was examined in an imprisoned male sample. Higher scores of the impulsive-disinhibited personality traits tended to be associated with carrying one or two copies of the 5-HTTPLR S allele (S/S homozygous and S/L heterozygous), and carrying two copies of the 5-HTTVNTR 12 allele (12/12 homozygous). Genotype, allele, haplotype and extended genotype distribution between low and high impulsive-disinhibited groups confirmed this association. Allele S and genotypes S/S+S/L at the 5-HTTLPR locus and allele 12 and genotype 12/12 at the 5-HTTVNTR locus were overrepresented in the high scoring group. Accordingly, allele S and allele 12 conferred a trend for risk to be in the high scoring group with an odds ratio (OR) of 1.8 (p < 0.035) and 1.7 (p < 0.014), respectively. In addition, extended genotype distribution shows that those S allele carriers (S/S homozygote and S/L heterozygote) that were also 12/12 homozygote, were overrepresented in the high scoring group (OR = 3.2; p < 0.004). The main risk of being in the high scoring group was assigned to those carrying two copies of the S-12 haplotype (OR = 5.7; p < 0.0007). We discuss the possible relationship between the two genetic serotonin polymorphisms and the personality impulsive-disinhibited traits investigated.
La divulgación científica fue el mecanismo traductor del lenguaje científico al habitual. El auto... more La divulgación científica fue el mecanismo traductor del lenguaje científico al habitual. El autor centra su interés en las palabras binómicas, aquellas que en el proceso de traducción pierden una serie de matices y llegarán así a tener diferentes significados para el científico y el público en general. El artículo dedica un apartado especial al papel de los científicos en la divulgación.
It has been hypothesized that the ratio of X-linked to autosomal sequence diversity is influenced... more It has been hypothesized that the ratio of X-linked to autosomal sequence diversity is influenced by unequal sex ratios in D. melanogaster populations. We conducted a genome scan of single nucleotide polymorphism (SNP) of 378 autosomal loci in a derived European population and of a subset of 53 loci in an ancestral African population. Based on these data and our already available X-linked data, we used a coalescent-based maximum likelihood method to estimate sex ratios and demographic histories simultaneously for both populations.
La comprensió dels mecanismes de l'evoluci
Molecular biology and evolution
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Papers by David de Lorenzo