General Catalyst

"These rent seekers who set drug prices care nothing about the patient." A. J. Loiacono saw that the same drug can have 600 different prices in a month, and a $120 copay is enough to make a third of Americans skip their prescription. He built Judi Health as a single system that processes prescription and medical claims for employers, so Americans get healthcare at the right price. Watch Holly Maloney's full conversation with AJ in the comments.

Congratulations to Chai Discovery on its $400M Series C. Chai treats medicine design as an engineering problem, one that can be solved with precision, speed, and scale. Eli Lilly, Pfizer, and Novartis are running its generative design suite, including the latest model Chai-3, against drug targets that have defeated traditional discovery methods. We co-led Chai's Series B, and we're proud to keep backing Joshua Meier, Jack Dent, Matthew McPartlon, Jacques Boitreaud, and the entire team.

Congratulations to Helsing on its $1.8B Series E. Helsing is one of the most consequential AI companies in Europe, bringing AI-native software to defense systems. These capabilities strengthen Europe’s deterrence and enable its democratic institutions to flourish. We’re proud to deepen our partnership with Dr. Gundbert Scherf, Torsten Reil, Niklas Köhler, and the entire team.

"In what world is hurling half an F-35 at somebody an effective way to deter them?" For decades, a single hypersonic missile has cost as much as $50 million. Bryon Hargis built SpaceX's Starshield business before founding Castelion to make them affordable at scale, and keep America safe. Watch Alexa Liautaud’s full conversation with Bryon in the comments.

We're proud to invest in Oratomic's $300M Series A. Oratomic plans to build a fault-tolerant quantum computer by the end of the decade, with a simpler path to quantum error correction built on reconfigurable atomic arrays trapped in focused laser beams. This leap could fundamentally transform our world, unlocking solutions to problems like drug and materials design that are computationally impossible today. Congratulations to Dolev Bluvstein and the entire team. cc: Alexa Liautaud

We backed 1001 AI at seed and are continuing to back the team in their $30M Series A. 1001 builds sovereign AI for the critical infrastructure that moves the physical world: aviation, ports, and energy. It's built and governed locally, so operators stay in control. Congratulations to Bilal Abu-Ghazaleh, Mohammed Fituri, and the entire team.

"We are as focused on spatial-temporal dynamics as Anthropic was on code." General Intuition's Pim de Witte explains why the next frontier in AI is teaching models how the physical world unfolds in time. These world models unlock robotics, simulation, and scientific discovery. Congratulations to Pim and the team on their Series A. We’re proud to keep backing them. Revisit Max Rimpel’s full conversation with Pim in the comments.

"The fintechs wanted to remove the friction, and hence remove the advisor. But that friction was passed down to the end client." For over a decade, the promise was that tech would replace the financial advisor. Instead, all the complexity and anxiety got handed to the customer. Rron Rexha founded Arca Wealth to fix that. AI handles the back-office work so advisors can focus on clients and help them reach their full financial potential. We're proud to lead Arca's Series A. Congratulations to Rron and the entire Arca team. In the comments: watch Nat Levy-Westhead’s full conversation with Rron, and read why we invested from Alex Tran and Nat.

Through its agreement to be acquired by Qualcomm, Modular aims to accelerate its mission and real-world impact by empowering developers everywhere with production-grade AI software. Congratulations to Chris Lattner, Tim Davis, and the extended Modular team on their journey to make AI’s compute layer unified, efficient, and accessible to all.

"Even if your sole mission was to make ChatGPT the best model possible for you, your efforts would be pretty much futile. The next generation comes and washes out all the context engineering and sticky notes you prepared." Every AI model starts each conversation from scratch, re-reading the same files and seeing only sticky notes about you and your work. Dan Biderman left academia to build Engram so AI can truly remember your world. We've backed Engram since its first round and are proud to support its $98M launch out of stealth. Congratulations to Dan, Sabri Eyuboglu, Jack Morris, Jessy Lin, Scott Linderman, Chris Ré, and the Engram team. In the comments: watch Marc Bhargava’s full conversation with Dan, and read why we invested from Marc and Max Rimpel.