📝 JAMA Patient Page: #NicotinePouches can produce blood nicotine levels similar to or higher than cigarettes and #ECigarettes, although nicotine absorption is slower than with smoking cigarettes. Nicotine pouches have not been shown to improve #SmokingCessation outcomes, but among adults who completely switch from smoking, they reduce exposure to many smoking-related carcinogens. https://ja.ma/4w3wLyv
JAMA
Book and Periodical Publishing
Chicago, Illinois 221,785 followers
JAMA is an international peer-reviewed general medical journal published online daily and in print weekly.
About us
JAMA, published continuously since 1883, is an international peer-reviewed general medical journal. JAMA is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.
- Website
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http://ja.ma/JAMA
External link for JAMA
- Industry
- Book and Periodical Publishing
- Company size
- 1,001-5,000 employees
- Headquarters
- Chicago, Illinois
- Type
- Nonprofit
- Founded
- 1883
- Specialties
- Internal Medicine, Dermatology, Neurology, Surgery, Pediatrics, Ophthalmology, Otolaryngology, General Psychiatry, Cardiology, Oncology, Health Policy, Psychiatry, Surgery, Cardiology, Hypertension, Cholesterol, Diabetes, and Cancer
Locations
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Primary
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330 N Wabash Ave
Chicago, Illinois 60611, US
Employees at JAMA
Updates
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Over the past 20 years, US Food and Drug Administration approvals for #Cancer medicines shifted away from chemotherapy and toward targeted therapy, immunotherapy, and antibody-drug conjugates. This Research Letter also found increasing use of single-arm trials and frequent regular approvals based on surrogate measures, which may inform regulatory discussions about confirmatory evidence and approval pathways. https://ja.ma/4h6BQSM
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💬 Editorial: For #SmokingCessation, nicotine #ECigarettes may be more effective than nicotine replacement therapies, while remaining substantially less harmful than smoking cigarettes. This evidence supports clinician discussions that differentiate what the data indicate about quitting smoking from values-based concerns about youth use, nicotine dependence, and tobacco industry involvement. https://ja.ma/4wyktiD
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💡 JAMA Insights: #NicotinePouches deliver nicotine through the oral mucosa and can produce nicotine levels comparable to cigarettes and #ECigarettes, with slower absorption. Their use is increasing in the US and is associated with oral adverse effects, nicotine dependence, and frequent use with other nicotine products, with public health implications for nicotine exposure among adolescents and young adults. https://ja.ma/3Tt5lo2
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🎯 Special Communication: For adults seeking #SmokingCessation, nicotine #ECigarettes should be included in patient-centered discussions alongside US Food and Drug Administration–approved medications such as nicotine replacement therapies, varenicline, and bupropion. This Special Communication indicates that nicotine e-cigarettes are more effective for smoking cessation than nicotine replacement therapies and are substantially less harmful than combustible cigarettes. https://ja.ma/3Rqd0CZ
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💬 Editorial: Among patients undergoing elective cardiac surgery, perioperative #dapagliflozin reduced the risk of #AcuteKidneyInjury in a randomized clinical trial, with no clear increase in adverse events. These findings support further evaluation of sodium-glucose cotransporter 2 inhibitors as a perioperative kidney-protective strategy, particularly because current guidance has often recommended withholding these medications before surgery. https://ja.ma/4pSJqTs
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📊 Research Summary: Starting #dapagliflozin 1 day before elective cardiac surgery reduced postoperative #AcuteKidneyInjury, but 30-day clinical outcomes were similar vs placebo. https://ja.ma/4h1sLur
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Among patients undergoing elective cardiac surgery, perioperative #dapagliflozin reduced postoperative #AcuteKidneyInjury (AKI) compared with placebo when started 1 day before surgery and continued for 4 doses. The trial supports a potential preventive strategy for AKI in elective cardiac surgery, an area in which medications to prevent postoperative AKI have not been identified. https://ja.ma/4yNUrcr
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Among patients undergoing elective cardiac surgery, perioperative #dapagliflozin reduced postoperative #AcuteKidneyInjury (AKI) compared with placebo when started 1 day before surgery and continued for 4 doses. The trial supports a potential preventive strategy for AKI in elective cardiac surgery, an area in which medications to prevent postoperative AKI have not been identified. https://ja.ma/3Rq2ED8
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🎙️ #HealthyDialogue: A new executive order and federal report propose increasing political control over which peer-reviewed biomedical research receives funding, a departure from the longstanding US model emphasizing expert-driven peer review. In the latest episode of the #HealthyDialogue podcast, Jeremy Berg, PhD, former editor in chief of Science and former director of the National Institute of General Medical Sciences, discussed the risks posed by politicization for scientific innovation, noting that past government investment in basic science—regardless of immediate utility—has resulted in significant advancements and economic growth. The episode considers how shifting funding decisions away from evidence-based processes may jeopardize US leadership in research. https://ja.ma/4pGDeNW