Academia.eduAcademia.edu

Bone Modification

description88 papers
group25 followers
lightbulbAbout this topic
Bone modification refers to the intentional alteration of bone structure or composition, often through physical, chemical, or biological processes. This field encompasses the study of changes in bone morphology, density, and mechanical properties, typically in the context of anthropology, archaeology, and biomedical research, to understand past behaviors, health, and treatment outcomes.
lightbulbAbout this topic
Bone modification refers to the intentional alteration of bone structure or composition, often through physical, chemical, or biological processes. This field encompasses the study of changes in bone morphology, density, and mechanical properties, typically in the context of anthropology, archaeology, and biomedical research, to understand past behaviors, health, and treatment outcomes.

Key research themes

1. How do biological and synthetic bone substitutes compare in managing large bone defects?

This research area examines the characteristics, clinical effectiveness, and limitations of various bone substitutes utilized as alternatives or supplements to autologous bone grafts for large bone defect reconstruction. It is critical due to the morbidity and limited availability associated with autografts, and the risks of disease transmission and immunogenicity with allografts and xenografts. Research in this theme focuses on evaluating osteoconductivity, osteoinductivity, biocompatibility, and long-term stability of diverse bone substitute materials, as well as their clinical indications and outcomes in different surgical contexts.

Key finding: This comprehensive review categorizes bone substitutes into biological (e.g., demineralized bone matrix, platelet-rich plasma) and synthetic materials (e.g., hydroxyapatite, calcium sulfate, tri-calcium phosphate ceramics),... Read more
Key finding: This work elucidates the distinctions among autografts, allografts, xenografts, and synthetic grafts focusing on their incorporation rates, immunogenic potential, and clinical applicability in foot and ankle surgeries. It... Read more
Key finding: This review critically examines limitations of traditional bone grafts, particularly autografts, in managing large bone defects and delayed unions, emphasizing challenges in harvesting sufficient graft volume and donor site... Read more
Key finding: Through a controlled canine model, this study compares autogenous bone chips with deproteinized bovine bone mineral (DBBM) in sinus floor elevation, revealing that while autologous bone demonstrates faster early bone volume... Read more

2. What roles do autologous cells and minimally manipulated tissue components play in enhancing bone regeneration in situ?

This theme explores innovative surgical techniques leveraging intraoperative isolation and application of living cells, such as bone marrow-derived mononuclear cells and mesenchymal stem cells, combined with scaffolds, to enhance bone healing without extensive ex vivo cell culture. It addresses regulatory, biological, and technological considerations surrounding the creation of tissue-engineered grafts in the operating room, emphasizing strategies to augment osteogenesis and angiogenesis by maintaining cell viability and biological signaling in grafts. Research includes advancements in combining autologous growth factors (e.g., platelet-rich fibrin) with bone substitutes and cementing the concept of tissue engineering directly during surgery.

Key finding: This review conceptualizes intraoperative tissue engineering in situ as a one-step surgical technique whereby scaffolds are enriched with minimally manipulated autologous cells isolated directly during the operative... Read more
Key finding: This technical note introduces a drilling system that enables harvesting of autologous, living bone chips with preserved cellular viability, critical for osteogenic potential. Conducted microscopic analysis demonstrates... Read more

3. How do fixation methods and mechanical environments influence bone defect healing and regeneration?

This theme investigates the impact of biomechanical stability and fixation modalities on the histological characteristics and rate of bone healing. It addresses how varying degrees of fixation rigidity (e.g., plates, internal fixators, external fixators) and micro-movement at fracture or defect sites modulate osteogenesis, callus formation, and tissue remodeling. The research highlights the interplay between mechanical stability, vascularity, and biological factors in facilitating optimal repair and underlines the importance of mechanical stimulus in regenerative outcomes.

Key finding: This experimental study on rabbits compares bone defect healing under three osteosynthesis methods—plate fixation, selfdynamisable internal fixator, and external fixator—evaluated by histological analysis after six weeks.... Read more
Key finding: This paper evaluates a novel low-speed, threaded osseoshaping tool designed to prepare implant sites while preserving osteocyte viability and reducing thermal/mechanical trauma compared to conventional high-speed drilling.... Read more

All papers in Bone Modification

While competition with large carnivores is likely to have shaped Middle Paleolithic hominins' subsistence behavior, palimpsested human and carnivore accumulations render the signal challenging to isolate. This study presents a detailed... more
Thirteen cases of individuals grouped together in buried structures following violent deaths are known to exist in Central European Neolithic sites. They are dated between the end of the 6th millennium and the middle of the third... more
In this research, we performed an entomological and botanical investigation to evaluate some historical records on the post-mortem history of Saint Davino Armeno (11th century). We formulated some intriguing hypotheses related to a... more
Rezension zu: Zeeb-Lanz, A. (ed.) (2019). Ritualised Destruction in the Early Neolithic – the Exceptional Site of Herxheim (Palatinate, Germany). (Forschungen zur Pfälzischen Archäologie, 8.2). Speyer: Generaldirektion Kulturelles Erbe -... more
Front cover: Detail of a mummy of a Greek youth named Artemidorus in a cartonnage body-case, 2nd century ad. British Museum, London (EA 21810) Printed and bound in the UK by 4edge Ltd, Hockley Papers used in this book by The British... more
Découvert en 2007, lors du diagnostic archéologique du projet de déviation de la RD766 de Châteaula-Vallière (Indre-et-Loire), l'établissement rural de La Tesserie (commune de Couesmes) a fait l'objet d'une fouille préventive par le... more
The Barnes Stone is an incised stone artifact found at the base of a roadcut along Red Springs Draw in the southern Bighorn Basin of Wyoming by Jeb Barnes, an avocational archaeologist from Thermopolis, Wyoming. We initially and... more
The Adaoust cave is located in southeastern France, in Provence, on the left bank of the Durance River (commune de Jouques, Bouches-du-Rhône). This Pliocene karstic network contains a stratigraphic sequence of human occupation from upper... more
This thesis is available for Library use on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement. I certify that all material in this thesis which is not my... more
Available online at www.journaltaphonomy.com Study of faunal series resulting from recent excavations in two caves in North Atlantic Morocco (Grotte à Hominidés- GH- and Grotte des Rhinocéros- GDR- at Thomas I and Oulad Hamida 1 quarries,... more
Study of faunal series resulting from recent excavations in two caves in North Atlantic Morocco (Grotte à Hominidés -GH -and Grotte des Rhinocéros -GDR -at Thomas I and Oulad Hamida 1 quarries, Casablanca) has yielded new evidence... more
Bilan des prospections Genette commune (Genetta genetta, Linnaeus, 1758) sur le domaine du Château de L’Escarelle (La Celle, Var) de 2022 à 2024
The Canary Islands were first settled by North African groups in the first millennium CE and, after a few centuries of interconnections with the mainland and between islands, remained isolated until the late medieval European expansion... more
Etude taphonomique du repaire d'hyènes de Camiac (Gironde, France). Eléments de comparaison entre un site naturel et un gisement préhistorique In: Bulletin de l'Association française pour l'étude du quaternaire-Volume 26-Numéro 2-1989.... more
Insects and other arthropods are used in different matters pertinent to the criminal justice system as they play very important role in the decomposition of cadavers. They are used as evidence in a criminal investigation to determine post... more
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or... more
Présenté par Henry de Lumley Résumé-Le site de plein air de Holon (Israël), daté d'environ 200 000 ans, a livré de nombreux restes fauniques et une industrie acheuléenne. L'association du lithique et de la faune démontre que les hominidés... more
For thirty years, neotaphonomical and actualistic researches have greatly contributed to our knowledge of the deposit processes of archaeological and palaeontological assemblages. Carnivores sensu lato are the most important bone... more
La caverne est l'une des plus développées du Périgord avec environ 8 km de galeries réparties sur trois niveaux. Une seule entrée donne accès à ce labyrinthe, aujourd'hui totalement asséché, hormis certains secteurs du niveau le plus... more
Présenté par Henry de Lumley Résumé-Le site de plein air de Holon (Israël), daté d'environ 200 000 ans, a livré de nombreux restes fauniques et une industrie acheuléenne. L'association du lithique et de la faune démontre que les hominidés... more
pour son aide, son soutien, sa disponibilité, ses conseils, sa compréhension, ses orientations… qui ont été un solide appui pour finaliser ce travail.
La grotte de Buraca Escura a été occupée durant les Paléolithique moyen et supérieur. Les occupations humaines étaient saisonnières (printemps, été) et de courtes durées. Elles sont associées à de nombreux oiseaux (corvidés dominants),... more
Le cannibalisme est issu d'une déformation linguistique de la terminologie Arawak (Amérindiens des Antilles) caribal qui signifie courageux. Christophe Colomb l'emploie pour désigner les Indiens des Caraïbes réputés pour être des mangeurs... more
The taphonomic history of the Middle Holocene archaeological component at the AEP-1 site was studied based on the analysis of bone modifications of the archaeofaunistic assemblage and the features of the geological matrix. Such indicators... more
Insects play a fundamental role in the removal and recycling of the organic matter from human cadavers and animal carcasses. Several factors can affect both the cadaver decomposition and colonisation by insects and other animals.... more
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or... more
Au sein de l’échantillon d’individus de Qafzeh (Basse Galilée), datés du Paléolithique moyen, Qafzeh 25 est représenté par des composants du squelette ayant été sérieusement altérés pendant la fossilisation, et tout particulièrement le... more
Découvert en 2007, lors du diagnostic archéologique du projet de déviation de la RD766 de Châteaula-Vallière (Indre-et-Loire), l'établissement rural de La Tesserie (commune de Couesmes) a fait l'objet d'une fouille préventive par le... more
This thesis is available for Library use on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement. I certify that all material in this thesis which is not my... more
La dégradation du cadavre d’un individu pourrait être influencée par les équipements biophysiologiques de ce dernier. L’effet de l’énergie biologique que procurent les ressources apportées à l’organisme, en l’occurrence l’alimentation,... more
Introduction.— La compréhension du processus de décomposition cadavérique est importante pour la détermination du délai post-mortem. Le but de cette étude est de décrire les différentes étapes de la décomposition de cadavres de porc... more