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Developmental Epidemiology

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lightbulbAbout this topic
Developmental Epidemiology is the study of the distribution and determinants of health-related states or events in populations, focusing on the developmental stages of individuals. It examines how biological, environmental, and social factors influence health outcomes across the lifespan, particularly during critical periods of growth and development.
lightbulbAbout this topic
Developmental Epidemiology is the study of the distribution and determinants of health-related states or events in populations, focusing on the developmental stages of individuals. It examines how biological, environmental, and social factors influence health outcomes across the lifespan, particularly during critical periods of growth and development.

Key research themes

1. How does prenatal and early life environment influence the risk of non-communicable diseases across the lifespan?

This research theme investigates the role of early developmental factors, particularly prenatal and perinatal exposures, in shaping susceptibility to chronic diseases such as diabetes, cardiovascular diseases, obesity, and mental health disorders later in life. It integrates epidemiological data, mechanistic insights, and animal models to elucidate the concept of Developmental Origins of Health and Disease (DOHaD), emphasizing the impact of maternal nutrition, intrauterine environment, and epigenetic modifications on offspring health. Understanding these early life influences is critical for shifting prevention focus from adult risk factor management to primordial and primary prevention targeting early developmental stages.

Key finding: This paper elucidates how both maternal undernutrition and overnutrition influence offspring body composition and metabolic risk, demonstrating the 'thin-fat' phenotype in Indian newborns with disproportionately higher... Read more
Key finding: Through evidence including the Dutch famine studies and twin research, this review confirms that adverse prenatal environments (nutritional restriction or overnutrition) induce disproportionate fetal growth and organ... Read more
Key finding: This article advances the DOHaD paradigm by focusing on environmental and occupational hazards alongside nutritional imbalances as early-life stressors disrupting development. It identifies epigenetic reprogramming,... Read more
Key finding: This review identifies family-level psychosocial and socioeconomic stressors (e.g., domestic violence, parental mental health issues, substance abuse) as critical environmental risk factors adversely affecting child... Read more

2. What are the methods and frameworks for assessing early childhood development and neurodevelopmental vulnerabilities in epidemiological studies?

This theme explores conceptual frameworks, epidemiological methodologies, and longitudinal cohort designs tailored to assess neurodevelopmental outcomes from infancy through adolescence. It spans analytic approaches such as latent class analysis and cumulative risk indices to capture multifactorial and dynamic developmental vulnerabilities. These frameworks facilitate identification of at-risk populations early, enabling targeted interventions and contributing to more standardized assessment approaches internationally.

Key finding: The study established a prospective longitudinal cohort, enrolling pregnant women before 24 weeks of amenorrhea, with detailed measurement of maternal exposures and repeated child neurodevelopmental assessments up to 8 years.... Read more
Key finding: Using latent class analysis on large population data (~67,000 children), this study identified distinct patterns of early developmental vulnerabilities, linking these classes with demographic and environmental exposures,... Read more
Key finding: This paper proposes a structured framework categorizing neuropsychological outcomes at multiple levels (e.g., cognitive, behavioral domains) to harmonize terminology and facilitate coherent assessment strategies across... Read more
Key finding: The study advances regression analytic methods to optimize weighting of cumulative risk indices encompassing environmental and genetic factors impacting neurodevelopment. By demonstrating that weighted composite indices... Read more

3. How do acute and chronic environmental and social stressors during epidemics and pandemics impact child growth and development?

This area focuses on the developmental and mental health consequences of epidemic-related social restrictions, parental stress, and infectious exposures on children and adolescents. It assesses mechanisms linking adverse childhood experiences (ACEs), toxic stress, and neurodevelopmental outcomes in the context of global health crises such as COVID-19. Findings here underscore the complex interplay of biological, psychosocial, and environmental stressors across developmental windows, informing strategies for mitigation and resilience promotion.

Key finding: This ongoing international prospective longitudinal study tests the hypothesis that prenatal SARS-CoV-2 exposure increases risk for atypical neurodevelopment through the maternal immune response and cytokine-mediated... Read more
Key finding: The study establishes a quantifiable dose-response relationship wherein each additional maternal adverse childhood experience (ACE) correlates with an 18% increased risk of suspected developmental delay at 24 months,... Read more

All papers in Developmental Epidemiology

Background: Sexual violence against children is a major global health and human rights problem. In order to address this issue there needs to be a better understanding of the issue and the consequences. One major challenge in... more
Two divergent areas of study have focused on the experiences of grief, i.e., bereavement, and on trauma and its aftermath. The grief literature has its foundations in psychodynamic and relational theories, and thus treatment modalities... more
I was interviewed on my dissertation research by Helen Milojevich, Graduate Student, American Psychological Association, Division 37, Section on Child Maltreatment
Trauma is a complex, common, challenging, confounding and dynamic issue that has only recently begun to be understood from holistic perspectives (Suzuki et al 2014). People of all ages, backgrounds, cultures and genders can experience... more
Full citation: Kisiel, C., Fehrenbach, T., Liang, Li-Jung, Stolbach, B., McClelland, G., Griffin, G., Maj, N., Briggs, E.C., Vivrette, R.L., Layne, C.M., & Spinazzola, J. (2014). Examining Child Sexual Abuse in relation to Complex... more
Full citation: Steinberg, A.M., Pynoos, R.S., Gerrity, E.T., Layne, C.M., Briggs, E.C., Vivrette, R.L., & Fairbank, J. (2014). The NCTSN Core Data Set: Emerging findings, future directions, and implications for theory, research,... more
Full citation: Layne, C.M., Greeson, J.K.P., Kim, Soeun, Ostrowski, S.A., Reading, S., Vivrette, R.L., Briggs, E.C., Fairbank, J.A., & Pynoos, R.S. (2014). Links between trauma exposure and adolescent high-risk health behaviors:... more
Full citation: Pynoos, R.S., Steinberg, A.M., Layne, C.M., Liang, L.J., Vivrette, R.L., Briggs, E. C., Kisiel, C., Habib, M., Belin, T.R., & Fairbank, J. (2014). Modeling constellations of trauma exposure in the National Child... more
Full citation: Layne, C. M., Briggs-King, E., & Courtois, C. (2014). Introduction to the Special Section: Unpacking risk factor caravans across development: Findings from the NCTSN Core Data Set. Psychological Trauma: Theory,... more
Canadian journalists and photojournalists working on national and international assignments.
Despite the evidence linking chronic early trauma with psychological distress, the latest edition of the Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) has excluded developmental trauma disorder from its taxonomy.... more
Treatment interventions specifically targeting reenactment and risk-taking behaviors, a serious effect of trauma, are a much-neglected area of work with traumatized adolescents. This paper begins by reviewing group therapies for... more
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