Introduction: Clobetasol propionate (0.05% standard dose formulation), a topical corticosteroid, ... more Introduction: Clobetasol propionate (0.05% standard dose formulation), a topical corticosteroid, leads to systemic side-effects like hypothalamic-pituitary-adrenal (HPA) axis suppression at doses as low as 2 g/day. The aim of this study was to evaluate HPA axis suppression, efficacy, and safety of clobetasol propionate (0.025%, formulation 5 and 13) versus currently marketed 0.05% cream in Indian patients with moderate-to-severe psoriasis. Methods: In this phase 2a investigator-blinded study, patients aged C 18 years with moderateto-severe psoriasis were randomized 1:1:1 to receive clobetasol propionate 0.025% formulation 5, or 13, or 0.05% cream; twice daily for 28 days. Safety endpoints included adrenocorticotropic hormone (ACTH) test results at day 28 (primary), and local tolerability at each visit (burning/stinging/pruritus, secondary). Efficacy endpoints included Psoriasis Global Assessment (PGA) score. Results: Overall, 88 patients received clobetasol propionate 0.025% formulation 5 and 13 (n = 29 for both) and 0.05% cream (n = 30). At day 28, the proportion of patients with an abnormal ACTH stimulation test (cortisol levels B 18 lg/dl) was numerically lower in 0.025% formulations: 5 (20.7%) and 13 (17.2%) compared with 0.05% cream (30.0%), (p = 0.320). Decrease in burning/stinging /pruritus scores were comparable in all treatment groups and PGA success rates were higher with 0.025% formulations: 5 (38.9%) and 13 (36.8%) compared with 0.05% cream (30.8%). Conclusion: Clobetasol propionate 0.025% could be an effective treatment for moderate-tosevere psoriasis compared with 0.05% cream,
ONGC drilling high angle offshore wells through shale
Oil & Gas Journal, 2005
... Titre du document / Document title. ONGC drilling high angle offshore wells through shale. Au... more ... Titre du document / Document title. ONGC drilling high angle offshore wells through shale. Auteur(s) / Author(s). BALRAJ Devang N. (1) ; NAVANI Rama D. (1) ; Affiliation(s) du ou des auteurs / Author(s) Affiliation(s). ... Pizarra no metamórfica. ; Pozo marino. ; Sondeo. ; ...
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