Marco Poloni

Mario Negri Institute for Pharmacological Research. Milan, IT, Neurosciences, Department Member

Followers

Following

Co-authors

Public Views

I am a retired neurologist, now engaged as voluntary researcher in IRCCS Mario Negri, Milan
Phone: +393356441842
Address: Via Broseta, 101/f

less

Interests

Uploads

Papers by Marco Poloni

Tutto

QUALCOSA DA RICORDARE UNITA' D'ITALIA-150 ANNI Premessa L'occasione della presente pubblicazione ... more QUALCOSA DA RICORDARE UNITA' D'ITALIA-150 ANNI Premessa L'occasione della presente pubblicazione è data dalla ricorrenza dei 150 anni dell'Unità d'Italia. Il periodo prescelto è stato quello che va dal 1861 al 1915: dalla nascita dello Stato unitario fino all'intervento italiano nella prima guerra mondiale. Gli articoli intendono ricordare i contributi offerti alla costruzione dello Stato unitario da alcuni scienziati, politici, uomini di cultura e illustrare alcuni aspetti della società del tempo. I problemi affrontati dall'élite liberale furono molteplici e di natura non facile; alterni i risultati: moderno avanzamento in alcune parti d'Italia, stagnazione in altre. Di ciò i testi qui raccolti rendono testimonianza. Non si intende peraltro entrare nel merito delle analisi storiografiche complessive sull'argomento, se non per insistere con due precisazioni. La prima serve a ricordare che, oltre ad un Settecento riformatore, molto enfatizzato, c'è stato in Italia un Ottocento liberale, altrettanto riformatore ed altrettanto grande: nella seconda metà del secolo, ad esempio, esso ha mostrato i volti, proprio a livello ministeriale, di personaggi sulla cui onestà d'intenti non è dato eccepire: siano sufficienti i nomi di Cesare Matteucci, Giuseppe Zanardelli e Luigi Luzzatti. La seconda riguarda la cultura scientifica in Italia che, in quel medesimo periodo e fino al 1915, fu di alto livello, apprezzata su scala europea e internazionale, specialmente nei campi della matematica, dell'astronomia e della biologia. Alla prima generazione, che ebbe la funzione di traghettare gli ideali risorgimentali nelle pieghe del nuovo Stato, appartengono

Download

Chronic progressive external ophthalmoplegia and myalgia associated with tubular aggregates

Acta Neurologica Scandinavica, 2009

Objective: The purpose of this report is to describe care of a patient with chronic progressive e... more Objective: The purpose of this report is to describe care of a patient with chronic progressive external ophthalmoplegia and bilateral vestibular hypofunction. Clinical Features: A 66-year-old patient presented with limited eye movement and mild ptosis, which led to a diagnosis of chronic progressive external ophthalmoplegia. Rotary chair testing suggested vestibular involvement. Other symptoms included dizziness, problems with balance, and chronic stiffness in his cervical and thoracic regions. He had anxiety about loss of function and limited exercise habits because of fear of falling. Examination methods included balance assessment, kinetic aspects of walking, and videonystagmography. Intervention and Outcome: He had already begun regular practice of vestibular rehabilitation exercises before receiving 18 sessions of manual and instrument-assisted chiropractic manipulation, along with mobilization, stretching, and transverse massage, over 37 weeks. In addition to self-reported improvements, there was substantially decreased postural sway during balance assessment and there were small improvements in eye movement, ptosis, and walking. Conclusion: This patient showed improvements in balance, eye movements, and walking while undergoing multimodal chiropractic care and practicing eye and balance exercises.

format_quotePost-treatment, the patient reported no light-headedness, dizziness, or balance issues, resuming activities like hiking and golf without difficulty.format_quote

Download

Multicentre, cross-cultural, population-based, case-control study of physical activity as risk factor for amyotrophic lateral sclerosis

Journal of neurology, neurosurgery, and psychiatry, Aug 23, 2018

To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (... more To investigate the association between physical activity (PA) and amyotrophic lateral sclerosis (ALS) in population-based case-control studies in three European countries using a validated and harmonised questionnaire. Patients with incident ALS and controls were recruited from five population-based registers in The Netherlands, Ireland and Italy. Demographic and data regarding educational level, smoking, alcohol habits and lifetime PA levels in both leisure and work time were gathered by questionnaire, and quantified using metabolic equivalent of task scores. Logistic regression models adjusting for PA-related factors were used to determine the association between PA and ALS risk, and forest plots were used to visualise heterogeneity between regions. 1557 patients and 2922 controls were included. We found a linear association between ALS and PA in leisure time (OR 1.07, P=0.01) and occupational activities (OR 1.06, P<0.001), and all activities combined (OR 1.06, P<0.001), wit...

L'imaging funzionale nelle disautonomie

[CSF levels of 5-HIAA in migraine during tryptophan therapy (author's transl)]

Rivista di patologia nervosa e mentale, 1974

[Insulinopoiesis in various neurologic syndromes. Study using oral glucose load and tolbutamide test]

Rivista di neurologia, 1974

A lead conversion method for staining thiamine pyrophosphatase and other phosphatases in rat brain after thin layer polyacrylamide gel isoelectric focusing

Basic and applied histochemistry, 1988

Rat brain thiamine pyrophosphatase (TPPase) was separated by thin layer polyacrylamide gel isoele... more Rat brain thiamine pyrophosphatase (TPPase) was separated by thin layer polyacrylamide gel isoelectric focusing (IF) and stained with a modification of the lead conversion method of Allen and Hyncik (1963). 10 bands with TPPase activity were observed in the pH range 4.6-7.1. The overall IF pattern of TPPase was similar to that of uridine diphosphatase and inosine diphosphatase but was clearly different from that of adenosine diphosphatase, p-nitrophenyl phosphatase, alpha-naphthyl phosphatase and thiamine monophosphatase. A semiquantitative assessment of TPPase isoenzymes has been performed using laser densitometry.

Unmasked Vertigo

Archives in Neurology & Neuroscience

Vertigo is a very unpleasant symptom for the patient and a complex clinical problem for the neuro... more Vertigo is a very unpleasant symptom for the patient and a complex clinical problem for the neurologist. First of all: a clear definition is needed, useful for both patients and clinicians and this doesn't seem a problem but, in my professional life I haven't yet found a satisfactory definition: I think that the following is clear and comprehensive: Vertigo is a distorted perception of the position or movement of head in the space. It may be accompanied by nausea, vomiting and by other vegetative symptoms; other signs may be nystagmus and postural deviations with falls. First of all, we must have complete knowledge of the structures which give a contribution to our perception of the position and shift of our head in the surrounding space. These are: 1) The vestibular receptors, 2) The sight, 3) The proprioceptive sensations conveyed by Goll and Burdach tracts in the posterior spinal cord, 4) The cerebellar afferents carrying unconscious information, 5) in a subsidiary way the exteroceptive sensitive system. Vestibular receptor is a very sophisticated structure devoted to monitor both the position of the head and its movement in the space: it fulfils this job through the osseous-membranous labyrinth positioned at skull base in the petrous bone and oriented according to the 3 main plans of the space, sagittal, coronal and horizontal; the apparatus is complex, with osseous and membranous components; the last, surrounded by perilympha and filled with endolymphatic fluid, contains utriculus and sacculous and semicircular channels with a larger extremity (ampulla); the epithelium is organized with maculas and cristae provided with hairy cells, disposed in such a way to be sensible to the position or shift of the head in every direction; utriculus and sacculous are linear acceleration and position receptors, while the semicircular channels are specifically sensible to rotation;.

Download

Circulating level of tumor necrosis factor-alpha and its soluble receptor: increased in the blood of patients with amyotrophic lateral sclerosis

Neuroscience Letters

Breathing pattern and respiratory mechanics in patients with amyotrophic lateral sclerosis

Breathing pattern and respiratory mechanics in patients with amyotrophic lateral scle

Download

Geographical clusters of amyotrophic lateral sclerosis and the Bradford Hill criteria

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Chronic progressive external ophthalmoplegia. Clinical, electrophysiological, histochemical and ultrastructural studies of 14 cases

Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie

Proceedings: EEG modification during Jendrassik's manoeuvre before and after prostigmine in Parkinsonian subjects

Electroencephalography and clinical neurophysiology, 1975

[Insulin availability in some familial inherited neurological syndromes (author's transl)]

Rivista di patologia nervosa e mentale, 1974

A case of Wolfram syndrome: Neurological features

The Italian Journal of Neurological Sciences, 1982

ABSTRACT

A randomized controlled trial of recombinant interferon α-2b in the treatment of Chinese patients with acute post-transfusion hepatitis C

Journal of Hepatology, 1994

To evaluate the efficacy of recombinant interferon α-2b in the treatment of patients with acute p... more

Breathing pattern and respiratory mechanics in patients with amyotrophic lateral sclerosis

European Respiratory Journal, 1997

Breathing pattern and respiratory mechanics in patients with amyotrophic lateral scle

Download

Microheterogeneity of CSF α2-macroglobulin in multiple sclerosis and other neurological diseases. A study performed by direct immunofixation after isoelectric focusing

Acta neurologica Belgica

ABSTRACT

Trauma and amyotrophic lateral sclerosis: a european population-based case-control study from the EURALS consortium

Amyotrophic lateral sclerosis & frontotemporal degeneration, Feb 24, 2017

To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic even... more To assess the association between amyotrophic lateral sclerosis (ALS) and previous traumatic events, age of trauma, and site of injury. A population-based case-control study was performed in five European countries (Italy, Ireland, France, United Kingdom, Serbia). Newly diagnosed ALS patients and matched controls were interviewed to collect relevant demographic factors and exposures. Key clinical features at diagnosis were collected in ALS patients. Trauma was any accidental event causing an injury. Injuries were dated and classified according to cause, severity, type, site, and complications. All exposures were censored five years before symptoms onset. Risks were computed as odds ratios (OR) with 95% confidence intervals (CI) using univariate and multivariate conditional logistic regression models. Five hundred and seventy-five ALS patients and 1150 controls were interviewed. Disabling traumatic events predominated in the cases (OR 1.54 (95% CI 1.24-1.92)) and maintained significa...

Influence of activation manouvres on EEG in Parkinson's disease: A study with topographical cerebral mapping

Electroencephalography and Clinical Neurophysiology

Objective: To determine the influence of Parkinsonian motor fluctuations on performance in a targ... more

Download

Marco Poloni

Uploads

Papers by Marco Poloni

Log In