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Hazardous Substances

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Hazardous substances are materials that pose a risk to human health or the environment due to their chemical properties, toxicity, flammability, reactivity, or corrosiveness. These substances can cause adverse effects through exposure, contamination, or improper handling, necessitating regulation and management to mitigate potential harm.
lightbulbAbout this topic
Hazardous substances are materials that pose a risk to human health or the environment due to their chemical properties, toxicity, flammability, reactivity, or corrosiveness. These substances can cause adverse effects through exposure, contamination, or improper handling, necessitating regulation and management to mitigate potential harm.

Key research themes

1. How do chemical composition databases enhance exposure and risk assessment of hazardous substances in consumer products?

This research area focuses on the development and utilization of comprehensive chemical and product composition databases to inform exposure, risk, and safety assessments of hazardous substances in consumer products. It addresses the challenge of limited quantitative data on chemical ingredients in products, and attempts to standardize and harmonize chemical function and product use categorization to support large-scale exposure modeling.

Key finding: This paper presents the Chemicals and Products Database (CPDat), an aggregated, harmonized resource containing quantitative and qualitative composition data for over 75,000 chemicals across more than 15,000 consumer products,... Read more
Key finding: This multidisciplinary consensus outlines scientific principles to improve hazard and risk assessments of industrial chemicals, emphasizing the need for robust chemical data, inclusive exposure evaluation, and integration of... Read more
Key finding: This article clarifies regulatory definitions and classification differences between hazardous substances (as defined by globally harmonized systems like GHS focusing on long-term health effects) and dangerous goods (mainly... Read more

2. What are effective management and treatment practices for hazardous waste and wastewater to mitigate environmental and health risks?

This theme covers strategies and technologies for hazardous waste management, focusing on industrial, hospital, and municipal sources. It includes collection, storage, transport, various treatment methods (physical, chemical, biological, thermal), and disposal practices aimed at reducing toxicity and environmental impact. Particular attention is given to hazardous wastewater from petroleum refining and medical facilities, along with decontamination protocols for protective equipment to prevent secondary contamination during hazardous chemical incidents.

Key finding: This paper outlines comprehensive hazardous waste management strategies including identification, collection, labeling, transport, storage, and treatment via physical (e.g., adsorption, distillation), chemical (e.g.,... Read more
Key finding: This work presents advanced wastewater treatment technologies specifically adapted for hazardous effluents generated by petroleum refining, focusing on dissolved air flotation (DAF) and flotation-filtration (DAFF) methods.... Read more
Key finding: This study focuses on the effectiveness of chemical and physical decontamination methods for personal protective equipment (PPE) contaminated with toxic industrial chemicals and chemical warfare surrogates. It identifies... Read more
Key finding: Focusing on hospital settings in Nigeria, this paper analyzes the generation and handling of hazardous wastes, including biomedical, toxic chemical, and cytotoxic materials. It stresses the prevalent improper practices such... Read more

3. How do public health agencies integrate toxicological knowledge and risk communication in managing acute chemical incidents and environmental exposures?

This theme explores the role of scientific toxicology, risk assessment frameworks, and communication strategies in emergency responses to hazardous substance releases. It covers institutional coordination, rapid exposure risk evaluations, public health risk assessments using source-pathway-receptor models, and the challenges of addressing community concerns during chemical incidents. The theme also includes how these methods impact policy development for chemical exposures and underscore the importance of trust and timely, evidence-based communication to protect public health.

Key finding: This volume synthesizes empirical studies showing profound and widespread public opposition to high-level nuclear waste repository siting due to perceived extreme risk, distrust in responsible agencies, and negative imagery... Read more
Key finding: This paper describes the UK Health Security Agency's model for providing authoritative, rapid toxicological advice during acute chemical incidents, including the use of source-pathway-receptor frameworks in public health risk... Read more
Key finding: This overview articulates the chemical hazards healthcare workers face and the corresponding international regulatory frameworks (e.g., EU REACH, U.S. OSHA and EPA standards) developed to address them. It underscores the... Read more

4. What environmental and human health risks are posed by hazardous chemical contaminants from plastic waste and illicit substances, and how can these be detected and assessed?

This theme investigates the occurrence, toxicity, and forensic analysis of hazardous chemicals released through improper handling of plastic wastes, e-waste, illicit beverages, and contaminated fish species. It encompasses studies on persistent organic pollutants (POPs) from brominated flame retardants in plastic waste, toxic contaminants in illicit liquors including methanol and metals, chemical residues in tattoo inks, and assessments of metal and organic pollutants in aquatic food chains. Understanding contamination sources, routes, and chemical profiles is essential for risk appraisal and development of remediation and regulatory interventions.

Key finding: This study reviews the hazardous chemical additives in plastic waste, notably brominated flame retardants and their transformation products, and their environmental fate following transfer from developed to developing... Read more
Key finding: The paper conducts forensic analysis of illicit liquors, revealing the detection of ethanol and furfural but absence of widely feared toxic compounds such as methanol and heavy metals in some samples. Using analytical... Read more
Key finding: Surveying 73 tattoo inks, the study identified high non-compliance with EU labeling laws and the presence of pigments known to cause allergic contact dermatitis, particularly in red inks. It detected metals such as iron,... Read more
Key finding: This investigation measured toxic and essential element concentrations in multiple fish species from the Sava River under varying hydrological conditions, finding generally low levels except for mercury, predominately... Read more
Key finding: This cross-sectional study finds that asphalt paving workers exposed to hot mix asphalt fumes display significantly elevated liver enzymes (AST, ALT, ALP), total bilirubin, and kidney markers (urea, creatinine) compared to... Read more

All papers in Hazardous Substances

An expression is suggested for correlating viscosity and Kinematic viscosity data over a wide range of pressure and temperature.
Background: Firefighting is extremely strenuous and physically demanding work and involves ability to cope with emergency life or death situations. The first study ever conducted on Kuwaiti firefighters was focused solely on... more
After two years of the pandemic, there is still concern about COVID-19, mainly among non-vaccinated and specific groups such as patients at risk, particularly, a group of young people who may or may not be vaccinated and who are hookah... more
After two years of the pandemic, there is still concern about COVID-19, mainly among non-vaccinated and specific groups such as patients at risk, particularly, a group of young people who may or may not be vaccinated and who are hookah... more
There is possibility of microbial contamination of any single-dose vials (SDVs), multiple-dose vials (MDVs) and admixtures (ADXs) during the preparation and injection to the patients that could be resulted in bloodstream infection. The... more
Concentrations of 38 gas-phase organic air toxics were measured over a 2-yr period at four different sites in and around Pittsburgh, PA, to investigate spatial variations in health risks from chronic exposure. The sites were chosen to... more
We applied several machine learning methods for developing QSAR models for prediction of acute toxicity to fathead minnow. The multiple linear regression (MLR) and artificial neural network (ANN) method were applied to predict 96 h LC 50... more
More than 40,000 organic chemicals have been identified as contaminants of emerging concern (CECs). Compared to population numbers and national debts, this may not initially appear to be a staggering number; yet, when considering rapid... more
We writing to illuminate an intriguing avenue of research that has the potential to revolutionize our approach to cardiovascular health: the Heavy Metal-atherosclerosis connection. Atherosclerosis-related diseases represent a significant... more
Background: Despite the high incidence of pemphigus in the Jewish population, data on the epidemiology and etiology of the disease in Israel are sparse. Objective: This study was conducted to identify clinical and epidemiologic features... more
This study represents a pioneering endeavour in consolidating previous measurements of naturally occurring radioactive materials (NORMs) within the Chattogram division, Bangladesh. Employing a meticulous approach, data was overlaid onto a... more
Lean manufacturing, which establishes small production "cells," or teams of workers, who complete an entire product from raw material processing through final assembly and shipment, increases health and safety hazards by mixing previously... more
A pilot study was performed in order to evaluate the usefulness of the Swiss Toxicological Information Center (STIC) in detecting cases of occupational illness. One hundred and fifty-two symptomatic occupational exposure cases were... more
This article provides a thorough explanation of the biodegradation process, highlighting its ecological importance as well as its applications in waste management and environmental health. Biodegradation is essential in converting... more
The events of 11 September 2001 became the catalyst for many to shift their disaster preparedness efforts towards mass-casualty incidents. Emergency responders, healthcare workers, emergency managers, and public health officials worldwide... more
Tobacco consumption is a significant global health issue, responsible for over eight million deaths annually. Various forms of tobacco, including cigarettes, hookah, smokeless tobacco, and electronic cigarettes, have been linked to oral... more
plate. A quality control (QC) plate was run in conjunction with the chemical exposure plate to account for inter-assay variation. Each chemical exposure was conducted two or three times. All laboratories successfully detected increases... more
One of the important 'hallmarks' of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is... more
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under... more
Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to... more
As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review... more
Carcinogenesis is thought to be a multistep process, with clonal evolution playing a central role in the process. Clonal evolution involves the repeated 'selection and succession' of rare variant cells that acquire a growth... more
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of... more
An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a... more
Ammonia is present in agrilture and commerce in many if not most communities. This report evaluates the toxic potency of ammonia, based on three ypes of data: anecdotal data, in some cas predating World War I, recnstructons of... more
Mathematical dosimetry models should improve the accuracy of various extrapolations required in dose-response assessment because they include explicit descriptions of the major mechanistic determinants of the exposure-dose-response... more
Persistent organic pollutants (POPs) are industrial chemicals and ubiquitous global contaminants. They share properties of persistence, toxicity, bioaccumulation potential and propensity for long-range environmental transport. POPs are... more
The provision of clean and safe drinking water is a fundamental human right and critical to public health. Pakistan is currently grappling with water scarcity and contamination, so ensuring the hydroenvironmental safety is a matter of... more
To establish a theoretical framework for achieving a chronological human lifespan of 120 years while maintaining a functional biological age of 70. The model proposes a synergy between telomere homeostasis, tumor suppressor gene... more
Occupational health and safety (OHS) has traditionally emphasized the use of personal protective equipment (PPE) as a frontline defense against workplace hazards. However, modern safety philosophy and regulatory frameworks increasingly... more
The Organic Products and Production Act 2023 (OPPA) — which came into force on 5 April 2023 — represents the most significant structural change to New Zealand's organic sector in its history. For the first time, the use of the term... more
Antibiotics alter the homeostasis of microbial communities and select for antibiotic-resistant bacteria in the wild. Thus, the accumulation of unnaturally high concentration of these substances in the environment due to their use in human... more
The unambiguous identification and quantification of hazardous materials is of increasing importance in many sectors such as waste disposal, pharmaceutical manufacturing, and environmental protection. One particular problem in waste... more
Safe patient handling remains a major challenge in healthcare settings, particularly during bed-to-stretcher transfers involving bedridden, obese, or critically ill patients. Manual lifting frequently exceeds safe load limits and... more
While a section on the industrializing countries has been included in this review, most of the available information is from North America and Europe, and this section is representative as opposed to comprehensive. Nevertheless, there are... more
Occupational Health Nursing is a specialized field of nursing focused on promoting and maintaining the health, safety, and well-being of workers across all industries. It integrates principles of nursing, public health, and workplace... more
The complexity of cancer requires a comprehensive approach to understand its diverse manifestations and underlying mechanisms. Initially outlined by Hanahan and Weinberg in 2000 and updated in 2010, the hallmarks of cancer provide a... more
Within EU FP7 project NANOVALID the (eco)toxicity of 7 well-characterized engineered nanomaterials (NMs) was evaluated by 15 bioassays in 4 laboratories. The highest tested nominal concentration of NMs was 100 mg/l. The panel of the... more
Toxicology is the overlapping branch of science, which extends dimensions within Chemistry, Biochemistry, Cell biology, Biotechnology, Pharmacology and Bioinformatics. Toxicology deals with study of toxic effects of chemicals on... more
Targeted gene lists have been used in clinical settings to specify breast tumor type, and to predict breast cancer prognosis and response to treatment. Separately, panels have been curated to predict systemic toxicity and xenoestrogen... more
The present investigation estimates the Water Quality Index (WQI) for groundwater near to industrial estate Bhilai, Durg District Chhattisgarh. The Water Quality Index was investigated by taking eleven parameters TDS, pH, Turbidity, Total... more
Objectives—To evaluate the capability of accident and emergency (A&E) departments in six health regions of England to safely decontaminate casualties exposed to hazardous chemicals. Methods—In January 1999 a postal questionnaire was sent... more
OBJECTIVES The aim of this study is to present the adaptation and implementation of the recommendations of the National Institute for Safety and Health at Work (Instituto Nacional de Seguridad y Salud en el Trabajo - INSHT) in the... more
This study combines longitudinal individual‐level data with neighborhood‐level industrial hazard data to examine the extent and sources of environmental inequality. Results indicate that profound racial and ethnic differences in proximity... more
Healthcare woi*.ers sometimes develop a deadly allergic reaction through repeated exposure to proteins in latex gloves. Although the latex glove industry apparently developed warnings to alert healthcare workers to the hazards associated... more
Podsumowując: wymóg uzyskiwania zezwoleń na ogniotrwałe włókna ceramiczne najprawdopodobniej umożliwi ich stosowanie jeszcze przez jakiś czas w warunkach, w których będą bezwzględnie konieczne, zanim zapadnie ostateczna decyzja ECHA.... more
Recent advances in coherent Raman spectroscopy hold exciting promise for many potential applications. For example, a technique, mitigating the nonresonant four-wave-mixing noise while maximizing the Raman-resonant signal, has been... more
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