Calibrate's science team had a great time at #ENDO2026 sharing new real-world evidence on the long-term impact of comprehensive obesity care.
Our team presented two analyses examining outcomes from Calibrate's digital metabolic reset program, which combines GLP-1 pharmacotherapy with intensive lifestyle intervention, coaching, nutrition guidance, and behavior change support.
🔬 In our 24-month longitudinal analysis (N = 1,921), participants achieved an average of 19.1% total body weight loss, while also demonstrating meaningful improvements across cardiometabolic health markers. Notably, 77% normalized at least one cardiometabolic biomarker, including high rates of normalization for HbA1c and liver function markers.
💪 In a second analysis (N = 3,642), participants achieved 15.9% total body weight loss at 12 months alongside favorable changes in body composition, including reductions in relative fat mass and preservation of muscle mass. These findings reinforce the importance of pairing GLP-1 therapy with adequate protein intake, resistance training, and ongoing behavioral support.
Beyond our own research, ENDO featured important discussions on the future of obesity treatment, including the affordability and value of GLP-1 therapies, advances in oral obesity medications, and emerging science on adipose tissue and metabolic health.
A huge thank you to everyone who contributed to these studies and to the researchers, clinicians, and industry leaders advancing the science of obesity care.
Michael Harvey
Linda Anegawa, MD, FACP, Dipl. ABOM, NBPAS
Christine May, Ph.D.
Veronica Khuen
Nicholas Richards
Christopher Goodrich
#ENDO2026 #ObesityMedicine #GLP1 #MetabolicHealth #DigitalHealth #WeightManagement #ClinicalResearch